Search

An electronic–photonic quantum system-on-chip—fabricated in a 45-nm complementary metal–oxide–semiconductor microelectronics foundry—provides scalable control of microring resonator quantum photon-pair sources through the monolithic integration of silicon quantum photonics with complex control electronics on the same die.

Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages share functional analogies but are not homologous, providing an example of convergent evolution.

A van der Waals heterostructure made from atomic layers of ferroelectric CuCrP₂S₆ and ferromagnetic Fe₃GeTe₂ can offer reversible, non-volatile ferroelectric control of two-dimensional magnetism.

The NLRC4 inflammasome, vital for immune defense, responds to infections and inflammation. Here the authors reveal the role of Bacillus thailandensis type III secretion system needle protein in activating NLRC4 complex through structural insights.

The kinesin-1 motor protein accesses open active and closed autoinhibited states. These states are regulated by a flexible elbow within a complex coiled-coil architecture. Now, a conformational switch has been developed by engineering the elbow to create a closed state that can be controllably opened with a de novo designed peptide to increase kinesin transport inside cells.

Previous work has shown the detection of quantum turbulence with mechanical resonators but with limited spatial and temporal resolution. Here, the authors demonstrate real-time detection of single quantum vortices in superfluid ⁴He with millisecond and micron resolution at temperatures of 10 millikelvin.

Budding yeast use multilayered regulation by Ait1, Gcn2, and the SEAC/GATOR complex to control TORC1 activity. This circuit design ensures that cells can adapt to low-quality nitrogen sources or shut down growth during starvation.

This study demonstrates a sub-THz free-space link, achieving 120 Gbit/s across 5 m enabled by compact plasmonic components with >300 GHz bandwidth, paving the way for next-generation scalable wireless networks at high carrier frequencies.

A terahertz field exceeding 1 V nm⁻¹ induced a structural phase transition in the top atomic layer of a bulk WTe₂ crystal. Differential imaging revealed a surface shift of 7 ± 3 pm and an electronic signature consistent with a topological phase transition.

The physical architectures of information storage dictate how data is encoded, organised and accessed. Here the authors use DNA with a single-strand overhang as a physical address to access specific data and do in-storage file operations in a scalable and reusuable manner.

I. Silber et al. discover a two-fold symmetry of the superconducting upper critical field in hexagonal 4Hb-TaS₂ just below T_c, a clear signature of nematic, two-component superconductivity. They further suggest a theoretical model that reconciles the nematic superconductivity with the previously-observed time-reversal-symmetry-breaking in this material.

Although optomechanics enables precision metrology, measurements beyond mechanical properties often require hybrid devices. Here, Kim et al. demonstrate that a ferromagnetic needle integrated with a torsional resonator can determine the magnetic properties and amplify or cool the resonator motion.

We present a protocol for high-resolution genome-wide mapping of nascent RNA polymerase II transcription initiation of both stable RNAs and transiently expressed RNAs using total RNA from diverse sample types.

Replicative errors contribute to genetic diversity needed for evolution but in high frequency lead to genomic stability. Here, NMR is used to show via a kinetic model that DNA dynamics can determine the misincorporation of A•G and A•8OG mismatches.

Graphene nanoelectromechanical systems enable the study of the interplay between electrical conductivity and mechanical properties. Here, the authors observe oscillations in the electromechanical response of bilayer graphene due to wrinkling, rather than the linear response seen in single layers.

Enzymes are viscoelastic, deformable machines. Mutating high-strain regions in these machines affect their catalytic function.

The authors study epitaxial thin films of the pyrochlore-sublattice compound LiTi2O4 by RIXS and ARPES. They observe cooperation between strong electron correlations and strong electron-phonon coupling, giving rise to a mobile polaronic ground state in which charge motion and lattice distortions are coupled.

Voltage-modulated scanning probe microscopy may elucidate important processes at solid–liquid interfaces, but it is complicated by the presence of mobile ions. By incorporating force sensitivity into a multidimensional measurement approach, Collins et al.present a technique that overcomes these limitations.

Hall resistance quantization measurements in the quantum anomalous Hall effect regime on a device based on the magnetic topological insulator V-doped (Bi,Sb)₂Te₃ show that the system can provide a zero external magnetic field quantum standard of resistance.

The role of oxytocin in modulating astrocytes during stress behaviour is not fully understood. Here the authors show that in the amygdala, oxytocin modulates stress related behaviour by transient Gαi-dependent retraction of astrocytic processes, followed by enhanced neuronal sensitivity to extracellular potassium.

Antiferromagnetic materials allow deterministic spin–orbit torque switching of perpendicular magnetization in ferromagnetic layers without external magnetic fields.

Nitazenes are potent synthetic opioids that are difficult to detect. Here, authors computationally redesign a plant receptor to create sensitive sensors capable of detecting diverse nitazenes and their metabolites in biological samples.

The authors identified a pH-dependent protonated status in the miR-21 precursor, which leads to additional base pairing in its secondary structure, thus affecting Dicer processing and miR-21 maturation.

RNA-binding protein TDP-43 contains a region forming a dynamic α-helical multimer that accounts for its functional role, evolutionary conservation, and disruption in amyotrophic lateral sclerosis, making for a possible therapeutic target.

Cagrilintide is a long-acting agonist of amylin and calcitonin receptors in late phase trials for obesity. Here, authors present structures of cagilintide with each target receptor, revealing the molecular basis for its non-selective action.

Dinoflagellates and cyanobacteria produce saxitoxin (STX) congeners that block voltage-gated sodium channels. Here authors show how amphibians may sequester STX congeners using a ‘lock and key’ mode, expanding the understanding of toxic sponge action.

The charge states in distant quantum dots can be coupled through an intermediate state in a third quantum dot.

Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

By pairing an octave-spanning terahertz microcomb with a terahertz Vernier microcomb, a continuous-wave laser at 871 nm is frequency divided to a radiofrequency clock output at 235 MHz. This laser is designed for frequency doubling to reach the ytterbium ion clock transition at 435.5 nm.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

X-ray crystallography, cryo-electron microscopy, structural modelling, biochemistry, cell biology, and evolutionary analysis enable characterization of ORF2p, the reverse transcriptase of the ancient ‘parasitic’ LINE-1 retrotransposon that has written around one-third of the human genome.

Optomechanical systems could form logic gates, but key requirements are two stable static states and the ability to switch between them. Here, the authors observe radiation-pressure induced buckling transitions in an optomechanical system, and control this transition by varying laser power and detuning.

Ferromagnetic semiconductors that have the critical properties of semiconductors and ferromagnetism at room temperature have so far proven elusive. Here, by doping black phosphorus with Cobalt, Fu, Qu, Hou, Chang and coauthors induce ferromagnetism that persists up to room temperature, all while maintaining black phosphorus’ semiconducting properties.

The authors propose wave-mixing cathodoluminescence, where laser-electron wave mixing in a nonlinear optical cavity upconverts low-frequency molecular resonances into visible photons, enabling nanoscale fingerprinting with visible light sources and detectors.

In the quantum Hall regime, strong interactions lead to the formation of unconventional spatially ordered electronic states. Qian et al. present evidence for a progressive sequence of transitions from isotropic through nematic to smectic phases in half-filled quantum Hall states.

Non-invasive imaging of articular cartilage has evolved markedly and can be used to monitor response to treatment and predict disease outcomes. This Review provides rheumatologists with a comprehensive update on current and emerging imaging and analysis techniques for the assessment of cartilage.

Host antibodies can alter the glycan binding of adhesin proteins from infectious bacteria, but the antibodies’ mechanisms of action remain unclear. Here, the authors define four mechanisms of modulation, including ligand mimicry and multiple modes of allosteric interference.

Andrew Feinberg, Christine Iacobuzio-Donahue and colleagues describe the epigenomic reprogramming that occurs during pancreatic cancer progression. They also show that hematogenous metastases co-evolve a dependence on the oxidative branch of the pentose phosphate pathway (oxPPP) and that oxPPP inhibition reverses chromatin reprogramming and blocks tumorigenic potential.

Evidence of modulated metallic and superconducting states stemming from an incommensurate structural stripe motif is reported in the bulk van der Waals superlattice SrTa₂S₅.

Free, or solvated, electrons in a solution are known to form at the interface between a liquid and a gas. Here, the authors use absorption spectroscopy in a total internal reflection geometry to probe solvated electrons generated at a plasma in contact with the surface of an aqueous solution

Quantum effects on biological reactions are investigated via magnetosensitive single-photon microspectroscopy. Using single-photon avalanche diode detectors, magnetosensitive radical pair photochemistry is detected to the single-photon level on 23 flavin molecules.

Edge current quantization in the integer quantum Hall effect is understood to arise due to noninteracting electrons circulating an incompressible insulating bulk. Here, the authors evidence compressible metal-like bulk behaviour in GaAs/AlGaAs Hall bars consistent with electronic interactions.

Microplastics (MPs) represent an environmental hazard which must be resolved by efficient, cheap, and sustainable remediation technology. Here the authors use an engineered algae to capture MPs and treat wastewater, the captured algae-plastic mix is upcycled into a tougher bioplastic composite.

The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi₂Te₄, and has implications for quantum chromodynamics, cosmology and string theory.

This author’s experiment demonstrated a stabilized low phase-noise optical terahertz source (dual-wavelength Brillouin laser) to the quantum rotational transition of a molecule (OCS) and achieved a fractional frequency instability of 5 × 10⁻¹² after 100ms of averaging.

The high speed switching and energy efficiency nature grant all-optical switching (AOS) great potential for future photonic integrated spintronic devices. Here the authors demonstrate the combination of AOS and domain wall propagation in Pt/Co/Gd synthetic ferrimagnetic racetrack for applications in photonic memory technologies.