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Looking for the start of metabolic disease in the gut

Max Nieuwdorp is an internist, endocrinologist and vascular medicine specialist at Amsterdam University Medical Centers. He chairs the Diabetes Center there and is chief of the Department and Laboratory of Vascular Medicine.

Max Nieuwdorp
Comments & Opinion08 May 2019
Nature Medicine

Volume: 25, P: 709
Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

Stool microbiota composition correlates with the ethnic backgrounds of people living in the same city, suggesting that geographical location and ethnicity have distinct effects on microbiota.

Mélanie Deschasaux
Kristien E. Bouter
Max Nieuwdorp
Research27 Aug 2018
Nature Medicine

Volume: 24, P: 1526-1531
Microbiome-derived ethanol in nonalcoholic fatty liver disease

A new study examines microbiome-generated ethanol in individuals with and without nonalcoholic fatty liver disease (NAFLD), concluding that microbial ethanol might contribute to pathogenesis in some patients with NAFLD.

Abraham S. Meijnikman
Mark Davids
Max Nieuwdorp
Research10 Oct 2022
Nature Medicine

Volume: 28, P: 2100-2106
Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

Shanthadevi Udayappan
Louise Manneras-Holm
Max Nieuwdorp
ResearchOpen Access06 Jul 2016
npj Biofilms and Microbiomes

Volume: 2, P: 1-10
Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

Mitsuokella jalaludinii and Anaerostipes rhamnosivorans degrade dietary phytate via synergistic interactions in the gut to produce the beneficial short-chain fatty acid propionate.

Willem M. De Vos
Minh Nguyen Trung
Thi Phuong Nam Bui
Research10 Jun 2024
Nature Microbiology

Volume: 9, P: 1812-1827
Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD

Accurate non-invasive biomarkers to diagnose MASLD-related fibrosis are urgently needed. Here the authors show a disease mechanism-related blood-based biomarker panel consisting of three biomarkers which is able to accurately identify MASLD patients with mild or advanced hepatic fibrosis.

Lars Verschuren
Anne Linde Mak
Roeland Hanemaaijer
ResearchOpen Access29 May 2024
Nature Communications

Volume: 15, P: 1-14
A gut prediction

Characteristic profiles of gut microorganisms in people with type 2 diabetes could aid diagnostics and therapies, but differing signatures between ethnicities and genders highlight the need for further studies. See Letter p.99

Willem M. de Vos
Max Nieuwdorp
News & Views29 May 2013
Nature

Volume: 498, P: 48-49
Phage-microbe dynamics after sterile faecal filtrate transplantation in individuals with metabolic syndrome: a double-blind, randomised, placebo-controlled clinical trial assessing efficacy and safety

Bacteriophages (phages) can modify the gut microbiome to benefit human health. Here, the authors report the results of a double blind, randomized, placebo-controlled trial, showing that faecal filtrate transplantation (FFT), containing phages from lean healthy donors, is safe and improves glycemic variability in patients with metabolic syndrome, while shifting the gut phage composition.

Koen Wortelboer
Patrick A. de Jonge
Hilde Herrema
ResearchOpen Access12 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Gut microbiome-wide association study of depressive symptoms

Here, the authors analyze the relation of fecal microbiota diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and in 1,539 subjects of the Amsterdam HELIUS cohort, finding associations with bacteria known to be involved in the synthesis of key neurotransmitters for depression.

Djawad Radjabzadeh
Jos A. Bosch
Najaf Amin
ResearchOpen Access06 Dec 2022
Nature Communications

Volume: 13, P: 1-10
Drivers and determinants of strain dynamics following fecal microbiota transplantation

Understanding the factors underlying colonization of donor microbes in recipients of fecal microbiota transplantation is a necessary first step to aid development of directed approaches that aim to couple colonization to clinical outcomes.

Thomas S. B. Schmidt
Simone S. Li
Peer Bork
ResearchOpen Access15 Sept 2022
Nature Medicine

Volume: 28, P: 1902-1912
Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome

Here, the authors characterize gut viromes in a cohort of individuals with metabolic syndrome, which they find associated with a highly widespread family of gut bacteriophages they name Candidatus Heliusviridae.

Patrick A. de Jonge
Koen Wortelboer
Hilde Herrema
ResearchOpen Access23 Jun 2022
Nature Communications

Volume: 13, P: 1-15
Non-nutritive sweeteners — too sweet to be wholesome?

Non-nutritive sweeteners (NNSs) seem to be a good substitute for sugar; they have the much-desired sweet taste but lack caloric content. A multi-arm randomized controlled trial assessing the effects of four NNSs on human metabolic health and the gut microbiome was recently published in Cell. The results further feed the long-standing debate on whether NNS use is indeed wholesome for human health.

Max Nieuwdorp
Hilde Herrema
News & Views17 Oct 2022
Nature Reviews Endocrinology

Volume: 18, P: 719-720
The high risk for type 2 diabetes among ethnic minority populations is not explained by low-grade inflammation

Mirthe Muilwijk
Max Nieuwdorp
Irene G. M. van Valkengoed
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
Rapid diagnosis of lung infections

Nanopore sequencing of the sputum metagenome identifies respiratory pathogens in six hours.

Andrei Prodan
Morten O. A. Sommer
Max Nieuwdorp
News & Views24 Jun 2019
Nature Biotechnology

Volume: 37, P: 725-726
Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

Small intestinal bacterial overgrowth (SIBO) has been associated with functional gastrointestinal disorders. Here, the authors show that SIBO may be a result of dietary preferences, and patient symptoms correlate with changes in small intestinal microbial composition but not with SIBO.

George B. Saffouri
Robin R. Shields-Cutler
Purna C. Kashyap
ResearchOpen Access01 May 2019
Nature Communications

Volume: 10, P: 1-11
Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

Maartje C. P. Cleophas
Jacqueline M. Ratter
Leo A. B. Joosten
ResearchOpen Access28 Jan 2019
Scientific Reports

Volume: 9, P: 1-10
Application of image guided analyses to monitor fecal microbial composition and diversity in a human cohort

Konstantina Zafeiropoulou
Bas Voermans
Evgeni Levin
ResearchOpen Access19 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
Kinetics of imidazole propionate from orally delivered histidine in mice and humans

Moritz V. Warmbrunn
Ilias Attaye
Max Nieuwdorp
ResearchOpen Access04 Nov 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-12
Machine learning analysis of sex and menopausal differences in the gut microbiome in the HELIUS study

Esther M. C. Vriend
Henrike Galenkamp
Barbara J. H. Verhaar
ResearchOpen Access19 Dec 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-11
Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

Pim W. Gilijamse
Annick V. Hartstra
Andrei Prodan
ResearchOpen Access27 Mar 2020
npj Biofilms and Microbiomes

Volume: 6, P: 1-10
Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T

Jasper O. Nuninga
René C. W. Mandl
Iris E. C. Sommer
Research12 Mar 2019
Molecular Psychiatry

Volume: 25, P: 1559-1568
Insulin resistance in obesity can be reliably identified from fasting plasma insulin

K W ter Horst
P W Gilijamse
M J Serlie
Research09 Jul 2015
International Journal of Obesity

Volume: 39, P: 1703-1709
Methods for quantifying adipose tissue insulin resistance in overweight/obese humans

K W ter Horst
K A van Galen
M J Serlie
Research03 May 2017
International Journal of Obesity

Volume: 41, P: 1288-1294

Search

Looking for the start of metabolic disease in the gut

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

Microbiome-derived ethanol in nonalcoholic fatty liver disease

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota

Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD

A gut prediction

Phage-microbe dynamics after sterile faecal filtrate transplantation in individuals with metabolic syndrome: a double-blind, randomised, placebo-controlled clinical trial assessing efficacy and safety

Gut microbiome-wide association study of depressive symptoms

Drivers and determinants of strain dynamics following fecal microbiota transplantation

Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome

Non-nutritive sweeteners — too sweet to be wholesome?

The high risk for type 2 diabetes among ethnic minority populations is not explained by low-grade inflammation

Rapid diagnosis of lung infections

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

Application of image guided analyses to monitor fecal microbial composition and diversity in a human cohort

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Kinetics of imidazole propionate from orally delivered histidine in mice and humans

Machine learning analysis of sex and menopausal differences in the gut microbiome in the HELIUS study

Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T

Insulin resistance in obesity can be reliably identified from fasting plasma insulin

Methods for quantifying adipose tissue insulin resistance in overweight/obese humans

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