Nature Search

Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

Y Lu
M Muller
G B Mills
Research13 Jun 2011
Oncogene

Volume: 30, P: 4567-4577
Multiple hominin dispersals into Southwest Asia over the past 400,000 years

Dated palaeolake sequences show that there were at least five Pleistocene hominin expansions into the Arabian interior, coinciding with windows of reduced aridity between 400 and 55 thousand years ago.

Huw S. Groucutt
Tom S. White
Michael D. Petraglia
ResearchOpen Access01 Sept 2021
Nature

Volume: 597, P: 376-380
NALIRIFOX in the frontline for metastatic pancreatic cancer: evidence beyond NAPOLI 3

Zev A. Wainberg
Eileen M. O’Reilly
Correspondence25 Oct 2024
Nature Reviews Clinical Oncology

Volume: 21, P: 900-901
Impressions of expression: bringing structure to the cell

This month’s Under the Lens discusses how combining cryo-electron tomography with cross-linking mass spectrometry has allowed elucidation of the mechanisms of transcription-coupled translation in bacteria.

Jan Böhning
Tanmay A. M. Bharat
Comments & Opinion31 Mar 2021
Nature Reviews Microbiology

Volume: 19, P: 346
Common variants at 12q15 and 12q24 are associated with infant head circumference

Vincent Jaddoe and colleagues report a genome-wide association study for infant head circumference. They identify variants in SBNO1 and near HMGA2 that are associated with this phenotype.

H Rob Taal
Beate St Pourcain
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 532-538
The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease

G P Pidgeon
J H Harmey
D J Bouchier-Hayes
ResearchOpen Access26 Nov 1999
British Journal of Cancer

Volume: 81, P: 1311-1317
A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

W K A Yung
R E Albright
V A Levin
ResearchOpen Access08 Aug 2000
British Journal of Cancer

Volume: 83, P: 588-593
Early evaluation of tumour metabolic response using [¹⁸F]fluorodeoxyglucose and positron emission tomography:a pilot study following the phase II chemotherapy schedule for temozolomide in recurrent high-grade gliomas

C S Brock
H Young
P M Price
ResearchOpen Access07 Jan 2000
British Journal of Cancer

Volume: 82, P: 608-615
Expression of Bcl-XS alters cytokinetics and decreases clonogenic survival in K12 rat colon carcinoma cells

Jordan S Fridman
Alnawaz Rehemtulla
Jonathan Maybaum
Research09 Dec 1998
Oncogene

Volume: 17, P: 2981-2991
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Vanessa S. Marsden
Liam O'Connor
Andreas Strasser
Research25 Sept 2002
Nature

Volume: 419, P: 634-637
The morbidity due to lower urinary tract function in spinal cord injury patients

P E V Van Kerrebroeck
E L Koldewijn
F M J Debruyne
Research01 May 1993
Spinal Cord

Volume: 31, P: 320-329
Ireland's research output set to slide

Mark Jessopp
Ruairi O'Reilly
Gordon Dalton
Correspondence14 Aug 2013
Nature

Volume: 500, P: 276
Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

Platelet production has been suggested to occur by apoptosis of megakaryocytes, but mitochondrially mediated apoptosis is known to be dispensable. Here, the authors show that death receptor-mediated apoptosis in mouse megakaryocytes is also not required for platelet biogenesis.

Emma C. Josefsson
Deborah L. Burnett
Benjamin T. Kile
Research17 Mar 2014
Nature Communications

Volume: 5, P: 1-14
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Paul Elliott, Martin Tobin, Cornelia van Duijn and colleagues report a genome-wide association study for pulse pressure and mean arterial pressure, identifying six new loci influencing these two traits.

Louise V Wain
Germaine C Verwoert
Cornelia M van Duijn
Research11 Sept 2011
Nature Genetics

Volume: 43, P: 1005-1011
Contact tracing is an imperfect tool for controlling COVID-19 transmission and relies on population adherence

Evaluations of the UK’s contact tracing programme have shown that it has had limited impact on COVID-19 control. Here, the authors show that with high levels of reporting and adherence, contact tracing could reduce transmission, but it should not be used as the sole control measure.

Emma L. Davis
Tim C. D. Lucas
Petra Klepac
ResearchOpen Access13 Sept 2021
Nature Communications

Volume: 12, P: 1-8
Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Analysis of community-tested cases of SARS-CoV-2 indicates that the B.1.1.7 variant is not only more transmissible than pre-existing variants, but may also cause more severe illness, and is associated with a higher risk of death.

Nicholas G. Davies
Christopher I. Jarvis
Ruth H. Keogh
Research15 Mar 2021
Nature

Volume: 593, P: 270-274
Treatment and survival of lymphoid malignancy in the north-west of England: a population-based study

JHAM Youngson
JM Jones
SS Banergee
Research01 Sept 1995
British Journal of Cancer

Volume: 72, P: 757-765
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma

Single-cell transcriptomics analyses of pretreatment and post-treatment peripheral blood mononuclear cells from patients treated with CD19 chimeric antigen receptor (CAR)-T products reveal a role for CAR-T regulatory cells in treatment relapse.

Nicholas J. Haradhvala
Mark B. Leick
Marcela V. Maus
Research12 Sept 2022
Nature Medicine

Volume: 28, P: 1848-1859
Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

Tsang et al. show that copper modulates the activity of autophagic kinases ULK1/2 to control autophagy, and is required for KRAS^G12D-driven tumour growth and cancer survival in response to starvation.

Tiffany Tsang
Jessica M. Posimo
Donita C. Brady
Research16 Mar 2020
Nature Cell Biology

Volume: 22, P: 412-424
Mapping the landscape of genetic dependencies in chordoma

Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.

Tanaz Sharifnia
Mathias J. Wawer
Stuart L. Schreiber
ResearchOpen Access06 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Exploring the prognostic impact of absolute lymphocyte count in patients treated with immune-checkpoint inhibitors

M. R. Conroy
H. O’Sullivan
S. O’Reilly
ResearchOpen Access18 Apr 2024
BJC Reports

Volume: 2, P: 1-7
Therapeutic developments in pancreatic cancer

The incidence of pancreatic ductal adenocarcinoma (PDAC) is rising. In this Review, Hu and O’Reilly summarize the latest advances and clinical trials for the treatment of PDAC, including biomarkers, targeted therapies and immunotherapy as well as novel clinical trial designs. They also discuss emerging therapeutic options for this disease.

Z. Ian Hu
Eileen M. O’Reilly
Reviews05 Oct 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 7-24
Real-time oxide evolution of copper protected by graphene and boron nitride barriers

M. Galbiati
A. C. Stoot
L. Camilli
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Author Correction: Tumour lineage shapes BRCA-mediated phenotypes

Philip Jonsson
Chaitanya Bandlamudi
Barry S. Taylor
Amendments and Corrections11 Dec 2019
Nature

Volume: 577, P: E1
A kinase-cGAS cascade to synthesize a therapeutic STING activator

Leveraging enzymatic selectivity, a single reaction stream provides a single diastereomer of the cyclic dinucleotide MK-1454, a promising immune-oncology drug candidate, without the use of protecting groups or chiral auxiliaries.

John A. McIntosh
Zhijian Liu
Matthew L. Maddess
Research16 Mar 2022
Nature

Volume: 603, P: 439-444
Modelling the medium-term dynamics of SARS-CoV-2 transmission in England in the Omicron era

This mathematical modelling study projects the dynamics of SARS-CoV-2 in England until the end of 2022 assuming that the Omicron BA.2 sublineage remains dominant. They show that booster vaccination was highly effective in mitigating severe outcomes and that future dynamics will depend greatly on assumptions about waning immunity.

Rosanna C. Barnard
Nicholas G. Davies
W. John Edmunds
ResearchOpen Access19 Aug 2022
Nature Communications

Volume: 13, P: 1-15
Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions

The Caucasus mountain range has impacted on the culture and genetics of the wider region. Here, the authors generate genome-wide SNP data for 45 Eneolithic and Bronze Age individuals across the Caucasus, and find distinct genetic clusters between mountain and steppe zones as well as occasional gene-flow.

Chuan-Chao Wang
Sabine Reinhold
Wolfgang Haak
ResearchOpen Access04 Feb 2019
Nature Communications

Volume: 10, P: 1-13
Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours

M Campone
V Levy
E Raymond
ResearchOpen Access06 Jan 2009
British Journal of Cancer

Volume: 100, P: 315-321
Prognostic significance of c-erbB-2 expression in node negative breast cancer

S Bianchi
M Paglierani
S Ciatto
Research01 Mar 1993
British Journal of Cancer

Volume: 67, P: 625-629
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.

Charis E. Teh
Najoua Lalaoui
Daniel H. D. Gray
ResearchOpen Access18 Nov 2016
Nature Communications

Volume: 7, P: 1-15
Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

Louise Fets
Paul C. Driscoll
Dimitrios Anastasiou
Amendments and Corrections23 Oct 2019
Nature Chemical Biology

Volume: 15, P: 1249
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice

Prime editing can efficiently correct the sickle-cell allele to produce wild-type haemoglobin in patient haematopoietic stem cells that engraft efficiently in mice, yielding erythrocytes resistant to hypoxia-induced sickling.

Kelcee A. Everette
Gregory A. Newby
David R. Liu
ResearchOpen Access17 Apr 2023
Nature Biomedical Engineering

Volume: 7, P: 616-628
Base editing of haematopoietic stem cells rescues sickle cell disease in mice

A custom adenine base editor can edit the variant of the β-globin gene that causes sickle cell disease into a non-pathogenic variant in human and mouse cells, and transplantation of the edited cells rescues sickle cell disease in mice.

Gregory A. Newby
Jonathan S. Yen
David R. Liu
Research02 Jun 2021
Nature

Volume: 595, P: 295-302
The nanomolar sensing of nicotinamide adenine dinucleotide in human plasma using a cycling assay in albumin modified simulated body fluids

Philipp Brunnbauer
Annekatrin Leder
Felix Krenzien
ResearchOpen Access31 Oct 2018
Scientific Reports

Volume: 8, P: 1-15
Annotation of the Corymbia terpene synthase gene family shows broad conservation but dynamic evolution of physical clusters relative to Eucalyptus

Jakob B. Butler
Jules S. Freeman
Mervyn Shepherd
Research10 Mar 2018
Heredity

Volume: 121, P: 87-104
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes

Guenther Koehne
Mikhail Doubrovin
Juri G. Gelovani Tjuvajev
Research24 Mar 2003
Nature Biotechnology

Volume: 21, P: 405-413
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Cyclin-dependent kinases are the principal drivers of cell cycle progression. Here the authors present several crystal structures of Cdk1 in complex with cyclin B and/or the assembly factors Cks1/2 and a small molecule inhibitor to reveal key features of this essential mitotic kinase.

Nicholas R. Brown
Svitlana Korolchuk
Jane A. Endicott
ResearchOpen Access13 Apr 2015
Nature Communications

Volume: 6, P: 1-12
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

S63845 specifically inhibits MCL1 and induces tumour cell death in vitro and in vivo in diverse cancer-derived cell lines with an acceptable safety margin.

András Kotschy
Zoltán Szlavik
Olivier Geneste
Research19 Oct 2016
Nature

Volume: 538, P: 477-482
Fas ligand–mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

Immune surveillance has been proposed to eliminate transformed cells and thereby limit tumor formation. Axel Kallies and colleagues now report that spontaneous B cell lymphoma development in Blimp1-deficient or Bcl6-overexpressing mice is accelerated by T cell deficiency and identify the Fas-Fas ligand pathway as a crucial mediator of T cell control of lymphoma growth.

Shoukat Afshar-Sterle
Dimitra Zotos
Axel Kallies
Research02 Feb 2014
Nature Medicine

Volume: 20, P: 283-290
Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade

In a retrospective analysis of patients with Lynch syndrome and primary cancers treated with immune checkpoint inhibitors, 12% developed subsequent malignancies, suggesting that this treatment may not eliminate risk in individuals predisposed to mismatch repair-deficient cancers, and ongoing surveillance is warranted.

Emily C. Harrold
Michael B. Foote
Zsofia K. Stadler
Research16 Oct 2023
Nature Medicine

Volume: 29, P: 2458-2463
Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent

Steven Lynham
Fabio Grundland Freile
Richard Beatson
ResearchOpen Access08 Apr 2021
Scientific Reports

Volume: 11, P: 1-7
Functional maturation in preterm infants measured by serial recording of cortical activity

N. J. Stevenson
L. Oberdorfer
S. Vanhatalo
ResearchOpen Access11 Oct 2017
Scientific Reports

Volume: 7, P: 1-7
Synopsis of Linear Associative Algebra

G. B. M.
Books & Arts30 Apr 1908
Nature

Volume: 77, P: 603-604
Passive voice

Alan M. Perlman
Correspondence11 Jul 1996
Nature

Volume: 382, P: 108
Emergence of human-adapted Salmonella enterica is linked to the Neolithization process

Ancient Salmonella enterica genomes from Neolithic Eurasian humans compared with those from later archaeological contexts illuminate the evolving host specificity of the pathogen from an initial multi-mammalian adaptation towards an increasingly human specialization.

Felix M. Key
Cosimo Posth
Johannes Krause
Research24 Feb 2020
Nature Ecology & Evolution

Volume: 4, P: 324-333
Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes

The second plague pandemic, caused by Yersinia pestis, started in the 14th century and recurred in Europe until the 18th century. Here, the authors reconstruct ancient Y. pestis genomes from human remains spanning this period, shedding light into the phylogeography and population structure of the European strains.

Maria A. Spyrou
Marcel Keller
Johannes Krause
ResearchOpen Access02 Oct 2019
Nature Communications

Volume: 10, P: 1-13
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

To better understand the phenotypic relationships of complex traits it is also important to understand their genetic overlap. Here, Frei et al. develop MiXeR which uses GWAS summary statistics to evaluate the polygenic overlap between two traits irrespective of their genetic correlation.

Oleksandr Frei
Dominic Holland
Anders M. Dale
ResearchOpen Access03 Jun 2019
Nature Communications

Volume: 10, P: 1-11
Chemical engineering of CRISPR–Cas systems for therapeutic application

CRISPR technology is revolutionizing the development of therapies for genetic disorders. However, the application of CRISPR-based therapeutics is challenged by factors impacting stability, efficiency, delivery and safety. This Review focuses on chemical engineering of CRISPR–Cas systems to address these issues, it assesses next-generation CRISPR–Cas systems, and it highlights CRISPR-based therapies that are approved or in clinical development.

Halle M. Barber
Adrian A. Pater
Daniel O’Reilly
Reviews17 Dec 2024
Nature Reviews Drug Discovery

Volume: 24, P: 209-230
Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Amendments and Corrections17 Jul 2020
Nature Biotechnology

Volume: 38, P: 1000

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