Nature Search

New gene functions in megakaryopoiesis and platelet formation

A meta-analysis of genome-wide association studies in more than 66,000 individuals identifies 68 new genomic loci that reliably associate with platelet count and volume, and reveals new gene functions.

Christian Gieger
Aparna Radhakrishnan
Nicole Soranzo

Research30 Nov 2011

Nature

Volume: 480, P: 201-208

Expression of Bcl-XS alters cytokinetics and decreases clonogenic survival in K12 rat colon carcinoma cells

Jordan S Fridman
Alnawaz Rehemtulla
Jonathan Maybaum

Research09 Dec 1998

Oncogene

Volume: 17, P: 2981-2991

Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish

Peter E Bayliss
Kimberly L Bellavance
Joanne Chan

Research26 Mar 2006

Nature Chemical Biology

Volume: 2, P: 265-273

Comparison of gemcitabine plus platinum analog with gemcitabine alone in advanced pancreatic cancer

Eileen M O'Reilly
Ghassan K Abou-Alfa

Comments & Opinion29 Apr 2008

Nature Clinical Practice Oncology

Volume: 5, P: 312-313

The morbidity due to lower urinary tract function in spinal cord injury patients

P E V Van Kerrebroeck
E L Koldewijn
F M J Debruyne

Research01 May 1993

Spinal Cord

Volume: 31, P: 320-329

Supraglottic airway in neonatal porcine model

Rachel N. Gibbs
Marwa Ramsie
Georg M. Schmölzer

Research21 Jan 2025

Pediatric Research

Volume: 98, P: 1134-1139

Implications of the school-household network structure on SARS-CoV-2 transmission under school reopening strategies in England

Many countries have closed schools as part of their COVID-19 response. Here, the authors model SARS-CoV-2 transmission on a network of schools and households in England, and find that risk of transmission between schools is lower if primary schools are open than if secondary schools are open.

James D. Munday
Katharine Sherratt
Sebastian Funk

ResearchOpen Access29 Mar 2021

Nature Communications

Volume: 12, P: 1-11

Master regulators of FGFR2 signalling and breast cancer risk

FGFR2 gene variation is associated with breast cancer risk but the molecular mechanism is unknown. Fletcher et al. provide a link between FGFR2 signalling and breast cancer susceptibility by demonstrating that FGFR2 signalling activates the ERa transcriptional network, which drives transcription of risk genes.

Michael N. C. Fletcher
Mauro A. A. Castro
Kerstin B. Meyer

ResearchOpen Access17 Sept 2013

Nature Communications

Volume: 4, P: 1-12

Treatment and survival of lymphoid malignancy in the north-west of England: a population-based study

JHAM Youngson
JM Jones
SS Banergee

Research01 Sept 1995

British Journal of Cancer

Volume: 72, P: 757-765

Evolving incidence patterns for locally advanced operable breast cancer by receptor status: SEER 2010–2021

Alexandra Thomas
Anthony Rhoads
Paul A. Romitti

ResearchOpen Access13 Nov 2025

npj Breast Cancer

Volume: 11, P: 1-9

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Tumour expression profiling is currently used for prognostic and predictive purposes without taking into account the intra patient heterogeneity. Here the authors show that cancer cell specific signatures overcome the tumour heterogeneity effect and result in better classification of colorectal cancer patients.

Philip D. Dunne
Matthew Alderdice
Mark Lawler

ResearchOpen Access31 May 2017

Nature Communications

Volume: 8, P: 1-12

Evolutionary and functional impact of common polymorphic inversions in the human genome

Inversions are a little-studied type of genomic variation that could contribute to phenotypic traits. Here the authors characterize 45 common polymorphic inversions in human populations and investigate their evolutionary and functional impact.

Carla Giner-Delgado
Sergi Villatoro
Mario Cáceres

ResearchOpen Access17 Sept 2019

Nature Communications

Volume: 10, P: 1-14

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh

ResearchOpen Access08 May 2020

Nature Communications

Volume: 11, P: 1-16

A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase

A PxL motif is identified in substrates of yeast phosphatase Cdc14. PxL functions as a docking motif for substrates and contributes to the timing of dephosphorylation during mitotic exit.

Meghna Kataria
Stephane Mouilleron
Frank Uhlmann

Research19 Nov 2018

Nature Structural & Molecular Biology

Volume: 25, P: 1093-1102

A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes

Validating crosslinking-mass spectrometry workflows is hampered by the lack of a ground truth to assess the robustness of the crosslink identifications. Here, the authors present a synthetic library of crosslinked peptides, enabling unambiguous discrimination of correct and incorrect crosslink identifications.

Rebecca Beveridge
Johannes Stadlmann
Karl Mechtler

ResearchOpen Access06 Feb 2020

Nature Communications

Volume: 11, P: 1-9

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder

ResearchOpen Access11 Jun 2019

Nature Communications

Volume: 10, P: 1-18

Modifying the insect cell N-glycosylation pathway with immediate early baculovirus expression vectors

Donald L. Jarvis
Eric E. Finn

Research01 Oct 1996

Nature Biotechnology

Volume: 14, P: 1288-1292

Temporal dynamics of brain activation during a working memory task

Jonathan D. Cohen
William M. Perlstein
Edward E. Smith

Research10 Apr 1997

Nature

Volume: 386, P: 604-608

Real-time oxide evolution of copper protected by graphene and boron nitride barriers

M. Galbiati
A. C. Stoot
L. Camilli

ResearchOpen Access09 Jan 2017

Scientific Reports

Volume: 7, P: 1-7

Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential (CHIP) at time of ASCT is associated with adverse outcomes in MM patients.

Tarek H. Mouhieddine
Adam S. Sperling
Irene M. Ghobrial

ResearchOpen Access12 Jun 2020

Nature Communications

Volume: 11, P: 1-9

Multiple hominin dispersals into Southwest Asia over the past 400,000 years

Dated palaeolake sequences show that there were at least five Pleistocene hominin expansions into the Arabian interior, coinciding with windows of reduced aridity between 400 and 55 thousand years ago.

Huw S. Groucutt
Tom S. White
Michael D. Petraglia

ResearchOpen Access01 Sept 2021

Nature

Volume: 597, P: 376-380

Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice

Rachelle Driscoll
Lucas Hampton
Andreas Weihofen

ResearchOpen Access24 Jan 2024

Scientific Reports

Volume: 14, P: 1-11

Comparison of intravenous and intraosseous administration of vasopressin and epinephrine during cardiopulmonary resuscitation of asphyxiated neonatal piglets

Marwa Ramsie
Po-Yin Cheung
Georg M. Schmölzer

Research13 Oct 2025

Pediatric Research

P: 1-9

Safety and pharmacokinetics of paclitaxel and the oral mTOR inhibitor everolimus in advanced solid tumours

M Campone
V Levy
E Raymond

ResearchOpen Access06 Jan 2009

British Journal of Cancer

Volume: 100, P: 315-321

Common variants at 12q15 and 12q24 are associated with infant head circumference

Vincent Jaddoe and colleagues report a genome-wide association study for infant head circumference. They identify variants in SBNO1 and near HMGA2 that are associated with this phenotype.

H Rob Taal
Beate St Pourcain
James F Wilson

Research15 Apr 2012

Nature Genetics

Volume: 44, P: 532-538

Impressions of expression: bringing structure to the cell

This month’s Under the Lens discusses how combining cryo-electron tomography with cross-linking mass spectrometry has allowed elucidation of the mechanisms of transcription-coupled translation in bacteria.

Jan Böhning
Tanmay A. M. Bharat

Comments & Opinion31 Mar 2021

Nature Reviews Microbiology

Volume: 19, P: 346

Prognostic significance of c-erbB-2 expression in node negative breast cancer

S Bianchi
M Paglierani
S Ciatto

Research01 Mar 1993

British Journal of Cancer

Volume: 67, P: 625-629

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Vanessa S. Marsden
Liam O'Connor
Andreas Strasser

Research25 Sept 2002

Nature

Volume: 419, P: 634-637

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

Platelet production has been suggested to occur by apoptosis of megakaryocytes, but mitochondrially mediated apoptosis is known to be dispensable. Here, the authors show that death receptor-mediated apoptosis in mouse megakaryocytes is also not required for platelet biogenesis.

Emma C. Josefsson
Deborah L. Burnett
Benjamin T. Kile

Research17 Mar 2014

Nature Communications

Volume: 5, P: 1-14

Ireland's research output set to slide

Mark Jessopp
Ruairi O'Reilly
Gordon Dalton

Correspondence14 Aug 2013

Nature

Volume: 500, P: 276

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Paul Elliott, Martin Tobin, Cornelia van Duijn and colleagues report a genome-wide association study for pulse pressure and mean arterial pressure, identifying six new loci influencing these two traits.

Louise V Wain
Germaine C Verwoert
Cornelia M van Duijn

Research11 Sept 2011

Nature Genetics

Volume: 43, P: 1005-1011

Contact tracing is an imperfect tool for controlling COVID-19 transmission and relies on population adherence

Evaluations of the UK’s contact tracing programme have shown that it has had limited impact on COVID-19 control. Here, the authors show that with high levels of reporting and adherence, contact tracing could reduce transmission, but it should not be used as the sole control measure.

Emma L. Davis
Tim C. D. Lucas
Petra Klepac

ResearchOpen Access13 Sept 2021

Nature Communications

Volume: 12, P: 1-8

Homo sapiens in Arabia by 85,000 years ago

A directly dated Homo sapiens phalanx from the Nefud desert reveals human presence in the Arabian Peninsula before 85,000 years ago. This represents the earliest date for H. sapiens outside Africa and the Levant.

Huw S. Groucutt
Rainer Grün
Michael D. Petraglia

Research09 Apr 2018

Nature Ecology & Evolution

Volume: 2, P: 800-809

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Analysis of copy number alterations in 1,451 patient-derived xenografts (PDXs) and matched patient tumor samples shows strong conservation from patient tumors through late-passage PDXs and a lack of systematic copy number evolution driven by the mouse host.

Xing Yi Woo
Jessica Giordano
Emilie Vinolo

ResearchOpen Access07 Jan 2021

Nature Genetics

Volume: 53, P: 86-99

Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Analysis of community-tested cases of SARS-CoV-2 indicates that the B.1.1.7 variant is not only more transmissible than pre-existing variants, but may also cause more severe illness, and is associated with a higher risk of death.

Nicholas G. Davies
Christopher I. Jarvis
Ruth H. Keogh

Research15 Mar 2021

Nature

Volume: 593, P: 270-274

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma

Single-cell transcriptomics analyses of pretreatment and post-treatment peripheral blood mononuclear cells from patients treated with CD19 chimeric antigen receptor (CAR)-T products reveal a role for CAR-T regulatory cells in treatment relapse.

Nicholas J. Haradhvala
Mark B. Leick
Marcela V. Maus

Research12 Sept 2022

Nature Medicine

Volume: 28, P: 1848-1859

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

Tsang et al. show that copper modulates the activity of autophagic kinases ULK1/2 to control autophagy, and is required for KRAS^G12D-driven tumour growth and cancer survival in response to starvation.

Tiffany Tsang
Jessica M. Posimo
Donita C. Brady

Research16 Mar 2020

Nature Cell Biology

Volume: 22, P: 412-424

Mapping the landscape of genetic dependencies in chordoma

Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.

Tanaz Sharifnia
Mathias J. Wawer
Stuart L. Schreiber

ResearchOpen Access06 Apr 2023

Nature Communications

Volume: 14, P: 1-17

The nanomolar sensing of nicotinamide adenine dinucleotide in human plasma using a cycling assay in albumin modified simulated body fluids

Philipp Brunnbauer
Annekatrin Leder
Felix Krenzien

ResearchOpen Access31 Oct 2018

Scientific Reports

Volume: 8, P: 1-15

Author Correction: Tumour lineage shapes BRCA-mediated phenotypes

Philip Jonsson
Chaitanya Bandlamudi
Barry S. Taylor

Amendments and Corrections11 Dec 2019

Nature

Volume: 577, P: E1

Modelling the medium-term dynamics of SARS-CoV-2 transmission in England in the Omicron era

This mathematical modelling study projects the dynamics of SARS-CoV-2 in England until the end of 2022 assuming that the Omicron BA.2 sublineage remains dominant. They show that booster vaccination was highly effective in mitigating severe outcomes and that future dynamics will depend greatly on assumptions about waning immunity.

Rosanna C. Barnard
Nicholas G. Davies
W. John Edmunds

ResearchOpen Access19 Aug 2022

Nature Communications

Volume: 13, P: 1-15

Exploring the prognostic impact of absolute lymphocyte count in patients treated with immune-checkpoint inhibitors

M. R. Conroy
H. O’Sullivan
S. O’Reilly

ResearchOpen Access18 Apr 2024

BJC Reports

Volume: 2, P: 1-7

Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions

The Caucasus mountain range has impacted on the culture and genetics of the wider region. Here, the authors generate genome-wide SNP data for 45 Eneolithic and Bronze Age individuals across the Caucasus, and find distinct genetic clusters between mountain and steppe zones as well as occasional gene-flow.

Chuan-Chao Wang
Sabine Reinhold
Wolfgang Haak

ResearchOpen Access04 Feb 2019

Nature Communications

Volume: 10, P: 1-13

Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum

Research25 Feb 2019

Nature Genetics

Volume: 51, P: 431-444

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.

Charis E. Teh
Najoua Lalaoui
Daniel H. D. Gray

ResearchOpen Access18 Nov 2016

Nature Communications

Volume: 7, P: 1-15

Annotation of the Corymbia terpene synthase gene family shows broad conservation but dynamic evolution of physical clusters relative to Eucalyptus

Jakob B. Butler
Jules S. Freeman
Mervyn Shepherd

Research10 Mar 2018

Heredity

Volume: 121, P: 87-104

Functional maturation in preterm infants measured by serial recording of cortical activity

N. J. Stevenson
L. Oberdorfer
S. Vanhatalo

ResearchOpen Access11 Oct 2017

Scientific Reports

Volume: 7, P: 1-7

Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent

Steven Lynham
Fabio Grundland Freile
Richard Beatson

ResearchOpen Access08 Apr 2021

Scientific Reports

Volume: 11, P: 1-7

Therapeutic developments in pancreatic cancer

The incidence of pancreatic ductal adenocarcinoma (PDAC) is rising. In this Review, Hu and O’Reilly summarize the latest advances and clinical trials for the treatment of PDAC, including biomarkers, targeted therapies and immunotherapy as well as novel clinical trial designs. They also discuss emerging therapeutic options for this disease.

Z. Ian Hu
Eileen M. O’Reilly

Reviews05 Oct 2023

Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 7-24

Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice

Prime editing can efficiently correct the sickle-cell allele to produce wild-type haemoglobin in patient haematopoietic stem cells that engraft efficiently in mice, yielding erythrocytes resistant to hypoxia-induced sickling.

Kelcee A. Everette
Gregory A. Newby
David R. Liu

ResearchOpen Access17 Apr 2023

Nature Biomedical Engineering

Volume: 7, P: 616-628

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