Nature Search

Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells

Nuclear architecture depends on proper regulation of lamin A/C modifications. Here, the authors show that TAF4A and NF-Y control Kansl2 expression in muscle stem cells, preserving genome stability and supporting muscle regeneration.

Angelina M. Georgieva
Krishna Sreenivasan
Thomas Braun
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-16
A New Fossil Human Population from the Wadi Halfa Area, Sudan

G. W. HEWES
H. IRWIN
A. SAXE
Research25 Jul 1964
Nature

Volume: 203, P: 341-343
ESTIMATION OF VITAMIN A

E. M. HUME
Research08 May 1943
Nature

Volume: 151, P: 535-536
Short-term storage and wind power availability (reply)

M. B. ANDERSON
R. J. LEICESTER
Research28 Jun 1979
Nature

Volume: 279, P: 818-819
Chemistry, Toxicology, Pharmacology and Microbiology of a new Acid-Stable Penicillin, Resistant to Penicillinase (BRL.1621)

J. H. C. NAYLER
A. A. W. LONG
R. SUTHERLAND
Research29 Sept 1962
Nature

Volume: 195, P: 1264-1267
‘Freshly Fractured Surface’ Theory of Silicosis

B. M. WRIGHT
Research30 Sept 1950
Nature

Volume: 166, P: 538-540
Inhibition of neuronal nitric oxide synthase prevents MPTP–induced parkinsonism in baboons

Philippe Hantraye
Emmanuel Brouillet
M. Flint Beal
Research01 Sept 1996
Nature Medicine

Volume: 2, P: 1017-1021
Quality assured spatial dataset of wildfire containment firelines and engagement outcomes 2017 to 2024

Alexander Arkowitz
Scott M. Ritter
David E. Calkin
ResearchOpen Access28 May 2025
Scientific Data

Volume: 12, P: 1-10
A Micropropagation, Molecular and Physiochemical Analysis of Canola Brassica napus L. From Seeds

Israr Khan
Muhammad Shuaib
Haji Akbar
ResearchOpen Access01 Oct 2010
Nature Precedings

P: 1
Parameterization of photoinhibition for phytoplankton

A model describing phytoplankton photosynthesis as a function of irradiance effectively captures photosynthetic rate above limiting and at photo-inhibiting irradiances, according to mathematical modelling of phytoplankton photosynthesis-irradiance curves.

Mohammad M. Amirian
Zoe V. Finkel
Andrew J. Irwin
ResearchOpen Access27 Aug 2025
Communications Earth & Environment

Volume: 6, P: 1-9
First observation of a quasar with a redshift of 4

S. J. Warren
P. C. Hewett
E. J. Kibblewhite
Research08 Jan 1987
Nature

Volume: 325, P: 131-133
Plasma Testosterone, Dominance Rank and Aggressive Behaviour in Male Rhesus Monkeys

ROBERT M. ROSE
JOHN W. HOLADAY
IRWIN S. BERNSTEIN
Research11 Jun 1971
Nature

Volume: 231, P: 366-368
A Strong Suppressor Specific for UGA

J. F. SAMBROOK
D. P. FAN
S. BRENNER
Research14 Apr 1967
Nature

Volume: 214, P: 452-453
Estimation of Vitamin A

E. M. HUME
Research07 Jan 1939
Nature

Volume: 143, P: 22-23
What kind of seed dormancy occurs in the legume genus Cassia?

Ailton G. Rodrigues-Junior
Marco T. A. Santos
Orlando C. De-Paula
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-11
A dwarf satellite galaxy in Sagittarius

R. A. Ibata
G. Gilmore
M. J. Irwin
Research21 Jul 1994
Nature

Volume: 370, P: 194-196
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons

TDP-43 nuclear clearance and loss-of-function, a hallmark of ALS-FTD and other neurodegenerative diseases, causes widespread inclusion of harmful cryptic exons. Here, the authors developed SnapMine to analyze cryptic exon inclusion across public RNA-seq datasets and identified that the antifungal ciclopirox olamine (CPX) induces such inclusion via heavy metal toxicity and oxidative stress.

Irika R. Sinha
Parker S. Sandal
Jonathan P. Ling
ResearchOpen Access25 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Sulphonamides with Diuretic Activity

W. LOGEMANN
P. N. GIRALDI
M. A. PARENTI
Research28 Nov 1959
Nature

Volume: 184, P: 1711
Nitrogen and phosphorus differentially control marine biomass production and stoichiometry

Mesocosm experiments revealed that both phytoplankton community composition and cellular acclimation influence marine particulate C:N:P ratios, with community shifts more sensitive to nitrogen supply and acclimation to the nutrient N:P supply ratio

Emily A. Seelen
Samantha J. Gleich
Seth G. John
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

Volume: 28, P: 1393-1403
Late Quaternary history of the Nile

D. A. Adamson
F. Gasse
M. A. J. Williams
Research06 Nov 1980
Nature

Volume: 288, P: 50-55
Microbiomes of microscopic marine invertebrates do not reveal signatures of phylosymbiosis

Characterization of bacterial microbiomes associated with >1,000 microscopic marine invertebrates reveals that phylosymbiosis is rare across animal lineages.

V. Boscaro
C. C. Holt
P. J. Keeling
Research26 May 2022
Nature Microbiology

Volume: 7, P: 810-819
Pseudo-linear summation explains neural geometry of multi-finger movements in human premotor cortex

Here, the authors show that Intracortical recordings in human motor cortex during attempted multi-finger movements reveal a largely linear code with two violations: magnitude normalization and greater shifts in tuning direction for weakly represented fingers.

Nishal P. Shah
Donald Avansino
Jaimie M. Henderson
ResearchOpen Access30 May 2025
Nature Communications

Volume: 16, P: 1-15
Composition of Cigarette Smoke : Some Low-Boiling Components

R. A. W. JOHNSTONE
P. M. QUAN
W. CARRUTHERS
Research29 Sept 1962
Nature

Volume: 195, P: 1267-1269
Interaction at a distance between λrepressers disrupts gene activation

A. Hochschild
M. Ptashne
Research24 Nov 1988
Nature

Volume: 336, P: 353-357
Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

Robert J. D'Amato
Guillermo M. Alexander
Solomon H. Snyder
Research28 May 1987
Nature

Volume: 327, P: 324-326
Tidal heating in an internal ocean model of Europa

M. N. Ross
G. Schubert
Research08 Jan 1987
Nature

Volume: 325, P: 133-134
Decrease in the space density of quasars at high redshift

P. A. Shaver
J. V. Wall
M. R. S. Hawkins
Research05 Dec 1996
Nature

Volume: 384, P: 439-441
Effects of High Pressure on the Strength and Structure of Martensites

S. VICTOR RADCLIFFE
M. SCHATZ
Research12 Oct 1963
Nature

Volume: 200, P: 161-163
Preparation and structure of crystals of the metallofullerene Sc₂@C₈₄

R. Beyers
C.-H. Kiang
S. Stevenson
Research21 Jul 1994
Nature

Volume: 370, P: 196-199
Notation for Genetic Factors of Human Immunoglobulins^*

R. CEPPELLINI
S. DRAY
Z. TRNKA
Research12 Feb 1966
Nature

Volume: 209, P: 653-655
Sympathoadrenal medullary activity in young, spontaneously hypertensive rats

HORST GROBECKER
MICHAEL F. ROIZEN
IRWIN J. KOPIN
Research20 Nov 1975
Nature

Volume: 258, P: 267
Star-forming galaxies at very high redshifts

Kenneth M. Lanzetta
Amos Yahil
Alberto Fernández-Soto
Research27 Jun 1996
Nature

Volume: 381, P: 759-763
Extended X-ray absorption fine structure determination of iron nitrogen distances in haemoglobin

P. Eisenberger
R. G. Shulman
S. Ogawa
Research01 Jul 1978
Nature

Volume: 274, P: 30-34
Use of the Orcinol - Sulphuric Acid Reaction in the Positive Identification of Certain Monosaccharides from a Salivary Mucoid

M. IRWIN
A. G. LEAVER
Research16 Jun 1956
Nature

Volume: 177, P: 1126
Distribution of Menaquinones in Aerobic Micrococcaceae

L. JEFFRIES
M. A. CAWTHORNE
S. A. PRICE
Research15 Jul 1967
Nature

Volume: 215, P: 257-259
Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin

A study finding an oestrogen-sensing signalling pathway that promotes melanoma metastasis only in female mice emphasizes the importance of recognizing sex-specific factors in cancer management.

Jérémy H. Raymond
Zackie Aktary
Véronique Delmas
ResearchOpen Access11 Jun 2025
Nature

Volume: 643, P: 801-809
The effects of urbanization on species interactions

Cities are renowned for catalyzing human interactions, but their effects on urban species are less clear. This Perspective argues for such a focus, and proposes a framework for studying interactions between urban species.

Pablo Moreno-García
Amy Savage
Daijiang Li
Reviews29 Jul 2025
Nature Cities

Volume: 2, P: 693-702
Natural and Cellular Immune Responses in Flinders Sensitive and Resistant Line Rats

Elliot M Friedman
Michael R Irwin
David H Overstreet
Research01 Sept 1996
Neuropsychopharmacology

Volume: 15, P: 314-322
Coupling carbon and energy fluxes in the North Pacific Subtropical Gyre

The biological pump is the key ecological component that links carbon and energy flow from oceanic surface waters to the abyss. Here the authors show that the elemental composition and energy content of sinking particulate matter can be used to develop a more comprehensive understanding of energy flow networks in the sea.

Eric Grabowski
Ricardo M. Letelier
David M. Karl
ResearchOpen Access26 Apr 2019
Nature Communications

Volume: 10, P: 1-9
Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice

Mazan-Mamczarz, Tsitsipatis and colleagues apply single-cell and spatial transcriptomics to mouse models of atherosclerosis to map senescent cells contributing to plaque instability and arterial remodeling. They define a transcriptomic signature of vascular senescence.

Krystyna Mazan-Mamczarz
Dimitrios Tsitsipatis
Allison B. Herman
Research14 Jul 2025
Nature Aging

Volume: 5, P: 1528-1547
Composition and Structure of the Liver Cell in Pregnancy

H. W. KOSTEBLITZ
ROSA M. CAMPBELL
Research15 Nov 1947
Nature

Volume: 160, P: 676-677
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Contraceptive Steroids and Sexual Activity

RICHARD P. MICHAEL
T. M. PLANT
Research10 May 1969
Nature

Volume: 222, P: 579-581
The atmosphere of Titan in late northern summer from JWST and Keck observations

JWST and Keck II spectral observations of Saturn’s moon Titan reveal methyl (CH₃) as well as non-local thermodynamic equilibrium emission bands of CO and CO₂. Imaging shows clouds in Titan’s northern hemisphere at several epochs, with some appearing to evolve in altitude.

Conor A. Nixon
Bruno Bézard
Robert A. West
Research14 May 2025
Nature Astronomy

Volume: 9, P: 969-981
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function

L M S Lau
J K Nugent
M S Irwin
Research13 Aug 2007
Oncogene

Volume: 27, P: 997-1003
Low-frequency resonance Raman spectroscopy of the deoxyhaemoglobin transient of photolysed carboxyhaemoglobin

M. J. Irwin
G. H. Atkinson
Research24 Sept 1981
Nature

Volume: 293, P: 317-318
Food as medicine in gastrointestinal cancer therapy

Diet modulates not only gastrointestinal cancer risk but also survivorship, providing an opportunity to improve cancer-related outcomes and quality of life through suitable dietary and lifestyle interventions in survivors of cancer. This Comment summarizes the evidence and ongoing trials investigating diet in gastrointestinal cancer survival, including potential underlying mechanisms and future research directions.

Fiona C. Malcomson
Mihir M. Shah
Urvi A. Shah
Comments & Opinion18 Sept 2025
Nature Reviews Gastroenterology & Hepatology

P: 1-3
1-Methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway

A. J. Bradbury
B. Costall
R. J. Naylor
Research02 Jan 1986
Nature

Volume: 319, P: 56-57

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