FAM122A is required for timely progression through the G0/G1 transition and checkpoint integrity. Here, the authors report the mechanism by which FAM122A inhibits the major B55α/PP2A Ser/Thr phosphatase using adjacent helices that dock on B55α and occlude the active site of PP2A/C.
- Jason S. Wasserman
- Bulat Faezov
- Xavier Graña
