The authors present the first in-depth analyses of liver pathology in a murine model of classical Farber disease. Characterizing their previously developed acid ceramidase-deficient Farber mice, they identify inflammation, fibrosis, and abnormal lipid profiles in livers/hepatocytes and highlight altered inflammatory, lipid, and sphingolipid gene expression pathways.
- Fabian P. S. Yu
- Salvatore Molino
- Jeffrey A. Medin
