Nature Search

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

Theresa V. Strong
Danilo A. Tagle
Roger L. Albin
Research01 Nov 1993
Nature Genetics

Volume: 5, P: 259-265
Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system

J. M. Greenberg
T. Boehm
T. H. Rabbitts
Research08 Mar 1990
Nature

Volume: 344, P: 158-160
Multimodal histopathologic models stratify hormone receptor-positive early breast cancer

The authors develop multimodal machine learning models to infer metastatic recurrence risk for early-stage, hormone receptor-positive breast cancer from H&E images using >6000 cases across three centers, outperforming a nomogram and unimodal methods.

Kevin M. Boehm
Omar S. M. El Nahhas
Jakob Nikolas Kather
ResearchOpen Access02 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons

Heterochromatin loss has been linked to aging and neurodegeneration. Here, the authors show that combined loss of HP1β and HP1γ in neurons results in de-repressesion of endogenous retroviruses, inflammation in glia including accumulation of complement C3, dendritic loss, and cognitive decline in mice.

A. G. Newman
J. Sharif
V. Tarabykin
ResearchOpen Access08 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Enzymatic replication of E. coli chromosomal origin is bidirectional

Jon M. Kaguni
Robert S. Fuller
Arthur Kornberg
Research15 Apr 1982
Nature

Volume: 296, P: 623-627
Optical dating of sediments

D. J. Huntley
D. I. Godfrey-Smith
M. L. W. Thewalt
Research10 Jan 1985
Nature

Volume: 313, P: 105-107
Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta

The extraembryonic yolk sac is a major location for developmental hematopoiesis, but it is unclear whether non-bone marrow sources contribute during adulthood. Here they show that embryonically derived endothelial-macrophage progenitor cells located in the aorta are a bipotent source of macrophage and endothelial cells later in life.

Anna E. Williamson
Sanuri Liyanage
Peter J. Psaltis
ResearchOpen Access17 Aug 2024
Nature Communications

Volume: 15, P: 1-21
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

Ranjan Mukherjee
Peter J. A. Davies
Richard A. Heyman
Research27 Mar 1997
Nature

Volume: 386, P: 407-410
Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery

Through RNA profiling of right ventricular tissue from patients with chronic thromboembolic pulmonary hypertension, Jafari et al. uncover mechanisms underlying disease severity-associated remodeling, identify key signaling molecules involved in fibrotic and proliferative pathways, and reveal processes driving right ventricular recovery after pulmonary endarterectomy.

Leili Jafari
Christoph B. Wiedenroth
Soni Savai Pullamsetti
ResearchOpen Access04 Jul 2025
Nature Cardiovascular Research

Volume: 4, P: 857-875
Ovarian cancer through a multi-modal lens

Prognostic information for patients with ovarian cancer is captured in clinico-genomic data, histopathology slides and computed tomography imaging; however, how to integrate these data is unclear. A study now presents a method for combining complementary data types to stratify risk and aid treatment selection in patients with ovarian cancer.

Hanna M. Hieromnimon
Alexander T. Pearson
News & Views28 Jun 2022
Nature Cancer

Volume: 3, P: 662-664
Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Host factors involved in filovirus infection are incompletely understood. Here, the authors used a haploid cell screening system to unveil CCZ1’s crucial role in regulating endosomal trafficking thus virus movement within cells and thereby impacting Marburg and Ebola infection.

Vanessa Monteil
Hyesoo Kwon
Ali Mirazimi
ResearchOpen Access25 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Quantum and classical criticality in a dimerized quantum antiferromagnet

The thermal and quantum fluctuations around a quantum critical point can be studied independently by mapping the evolution of the spin dynamics in the critical region of a dimerized quantum magnet using neutron scattering.

P. Merchant
B. Normand
Ch. Rüegg
Research06 Apr 2014
Nature Physics

Volume: 10, P: 373-379
Chemoproteogenomic stratification of the missense variant cysteinome

Cancer genomes are rife with genetic variants, and one key outcome of this variation is widespread gain-of-cysteine mutations. Here, the authors pair cysteine chemoproteomics with genomics to investigate the landscape of cysteine genetic variation.

Heta Desai
Katrina H. Andrews
Keriann M. Backus
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-24
Defining the role of common variation in the genomic and biological architecture of adult human height

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Andrew R Wood
Tonu Esko
Timothy M Frayling
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1173-1186
Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Deepak S. Lala
Ranjan Mukherjee
Richard A. Heyman
Research03 Oct 1996
Nature

Volume: 383, P: 450-453
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

The role of ancestry in target discovery remains to be systematically explored. Here, the authors analyse data from 611 genome scale CRISPR/Cas9 viability experiments in human cell line models as part of The Cancer Dependency Map and identify ancestry-associated genetic dependencies.

Sean A. Misek
Aaron Fultineer
Jesse S. Boehm
ResearchOpen Access07 Jun 2024
Nature Communications

Volume: 15, P: 1-11
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Rapid water disinfection using vertically aligned MoS₂ nanofilms and visible light

Few-layered, vertically aligned MoS₂ films can efficiently harvest visible light for photocatalytic water disinfection, allowing >99.999% bacteria to be rapidly inactivated.

Chong Liu
Desheng Kong
Yi Cui
Research15 Aug 2016
Nature Nanotechnology

Volume: 11, P: 1098-1104
Integrated genetic and pharmacologic interrogation of rare cancers

Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.

Andrew L. Hong
Yuen-Yi Tseng
Jesse S. Boehm
ResearchOpen Access22 Jun 2016
Nature Communications

Volume: 7, P: 1-9
A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion

Susan E. Holmes
Beth A. Dombroski
Haig H. Kazazian Jr.
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 143-148
Fingerprints of supersymmetric spin and charge dynamics observed by inelastic neutron scattering

Supersymmetric theories have partner bosonic and fermionic particles. Here, the authors use neutron spectroscopy on spin-ladder materials paired with matrix-product-states calculations to identify superpartner excitations.

Björn Wehinger
Franco T. Lisandrini
Christian Rüegg
ResearchOpen Access04 Apr 2025
Nature Communications

Volume: 16, P: 1-10
Photoreduction of FeCl₄⁻ in Alcohol

G. J. BREALEY
M. G. EVANS
N. URI
Research02 Dec 1950
Nature

Volume: 166, P: 959-960
Structure of Graphitic Oxide

F. ARAGON DE LA CRUZ
J. M. COWLEY
Research03 Nov 1962
Nature

Volume: 196, P: 468-469
Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC

DeNardo and colleagues show that tissue-resident macrophages (TRMs) have a protective role during pancreas inflammation by triggering the activation of fibroblasts, but that TRM-driven fibrosis drives pancreas cancer pathogenesis.

John M. Baer
Chong Zuo
David G. DeNardo
Research10 Aug 2023
Nature Immunology

Volume: 24, P: 1443-1457
Electromotive Force from the Light of the Stars

GEORGE M. MINCHIN
Research18 Jan 1894
Nature

Volume: 49, P: 270
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

Endothelial to mesenchymal transition (EndMT) is a crucial developmental process that also plays a role in the pathogenesis of some diseases. Here the authors show that EndMT contributes to the development of atherosclerosis in mice and humans, and is associated with complex human plaques that may be prone to rupture.

Solene M. Evrard
Laura Lecce
Jason C. Kovacic
ResearchOpen Access24 Jun 2016
Nature Communications

Volume: 7, P: 1-16
Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy

Louis M. Kunkel
Research03 Jul 1986
Nature

Volume: 322, P: 73-77
A Sensitive Micro-Spectrophotometric Method for Succinate Analysis

M. B. WAITZMAN
E. Q. ADAMS
Research12 Jul 1958
Nature

Volume: 182, P: 129
New genetic loci link adipose and insulin biology to body fat distribution

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Dmitry Shungin
Thomas W. Winkler
Karen L Mohlke
Research11 Feb 2015
Nature

Volume: 518, P: 187-196
Large-scale association analysis identifies new risk loci for coronary artery disease

Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and 130,681 controls. They identify 15 susceptibility loci, refine previous associations and use network analysis to highlight biological pathways.

Panos Deloukas
Stavroula Kanoni
Nilesh J Samani
Research02 Dec 2012
Nature Genetics

Volume: 45, P: 25-33
Tuning the reactivity of carbon surfaces with oxygen-containing functional groups

Distinguishing the influence of oxygen functional groups in carbon materials is important but elusive. Here, the authors combine experimental and machine learning techniques and reveal that phenolic groups are more acidic than carboxylic groups.

Jiahua Zhou
Piaoping Yang
Dionisios G. Vlachos
ResearchOpen Access21 Apr 2023
Nature Communications

Volume: 14, P: 1-11
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee
Jeffrey T. Laydon
Peter R. Young
Research29 Dec 1994
Nature

Volume: 372, P: 739-746
Shifting of the Earth's Axis

W. M. FLINDERS PETRIE
Research09 Oct 1884
Nature

Volume: 30, P: 561
Crystal structure of the tyrosine kinase domain of the human insulin receptor

Stevan R. Hubbard
Lei Wei
Wayne A. Hendrickson
Research29 Dec 1994
Nature

Volume: 372, P: 746-754
Direct observation of kinesin stepping by optical trapping interferometry

Karel Svoboda
Christoph F. Schmidt
Steven M. Block
Research21 Oct 1993
Nature

Volume: 365, P: 721-727
Fibrin-stabilizing Factor (Factor XIII) in the Fetus and the Newborn Infant

P Henriksson
U Hedner
L Lorand
Research01 Sept 1974
Pediatric Research

Volume: 8, P: 789-791
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa

Zheng-An Lu
Alexander Ploner
Sarah E. Bergen
ResearchOpen Access23 Sept 2025
Molecular Psychiatry

P: 1-10
Anomalous ₁₃C depletion in early Precambrian graphites from Superior Province, Canada

M. Schoell
F.-W. Wellmer
Research23 Apr 1981
Nature

Volume: 290, P: 696-699
Specific acyclic isoprenoids as biological markers of methanogenic bacteria in marine sediments

S. C. Brassell
A. M. K. Wardroper
G. Eglinton
Research23 Apr 1981
Nature

Volume: 290, P: 693-696
Biosorption of nickel and cadmium using Pachira aquatica Aubl. peel biochar

Talita L. S. Nascimento
Karine F. S. Oliveira
Renata M. Braga
ResearchOpen Access01 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

Liang Tong
Susan Pav
Christopher A. Pargellis
Research01 Apr 1997
Nature Structural Biology

Volume: 4, P: 311-316
Many human L1 elements are capable of retrotransposition

Donna M. Sassaman
Beth A. Dombroski
Haig H. Kazazian Jr
Research01 May 1997
Nature Genetics

Volume: 16, P: 37-43
Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

D.W. Johnson
J.N. Berg
D.A. Marchuk
Research01 Jun 1996
Nature Genetics

Volume: 13, P: 189-195
Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases. Here the authors report a case series of three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation, and identify de novo truncating and missense variants in the Src-family tyrosine kinase LYN.

Adriana A. de Jesus
Guibin Chen
Raphaela Goldbach-Mansky
ResearchOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1-13
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
Annual laminations in the sediments of Loe Pool, Cornwall

H. L. K. Simola
M. A. Coard
P. E. O'Sullivan
Research19 Mar 1981
Nature

Volume: 290, P: 238-241
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Heterozygous mutateons in the caspase-8 cleavage site of RIPK1 cause a range of autoinflammatory symptoms in humans, and caspase-8 cleavage of RIPK1 in a mouse model limits TNF-induced cell death and inflammation.

Najoua Lalaoui
Steven E. Boyden
John Silke
Research11 Dec 2019
Nature

Volume: 577, P: 103-108
Turning straw into reduced graphene oxide

In the popular nineteenth century fairy tale and perhaps among the first tales of upcycling, Rumpelstiltskin spun waste straw into gold. Now, researchers convert straw and other cellulosic waste biomass into reduced graphene oxide, a valuable and prized nanomaterial, through a simple reaction.

Kevin M. Wyss
James M. Tour
News & Views16 Dec 2024
Nature Sustainability

Volume: 7, P: 1558-1559
Shuttle HAT for mild alkene transfer hydrofunctionalization

Hydrogen atom transfer (HAT) from a metal-hydride is a reliable and powerful method for functionalizing unsaturated C–C bonds in organic synthesis. Herein, the authors show that reverse process of HAT to an alkene can be leveraged to generate catalytically active Co–H species in an application of shuttle catalysis coined shuttle HAT.

Tanner C. Jankins
Philip M. Blank
Bill Morandi
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-9
A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice

Studying GnRH neuroendocrine cells in the mouse olfactory bulb (GnRH^OB neurons), Decoster et al. show that these cells respond to female odors and their activation regulates males’ female-odor preference and mating behavior.

Laurine Decoster
Sara Trova
Paolo Giacobini
Research02 Aug 2024
Nature Neuroscience

Volume: 27, P: 1758-1773

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