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Showing 1–5 of 5 results
Advanced filters: Author: M. Gargaro Clear advanced filters

  • Initial exposure to lipopolysaccharide (LPS) induces endotoxin tolerance, which reduces immunological reactions to LPS; here it is shown that primary LPS challenge is controlled by AhR, TDO2 and IL-10, whereas sustained effects require AhR, IDO1 and TGF-β, allowing for disease tolerance with reduced immunopathology in infections.

    • Alban Bessede
    • Marco Gargaro
    • Paolo Puccetti
    Research
    Nature
    Volume: 511, P: 184-190

  • Two recent crystal structures show channel-forming bacterial toxins as soluble monomers (colicin la) or transmembrane pores (α-haemolysin). Together with other data, these structures imply that toxin activity requires dramatic conformational changes.

    • Frederick M. Hughson
    News & Views
    Nature Structural Biology
    Volume: 4, P: 89-92

  • The solutiuon structure of the GAGA DMA-binding domain reveals an N-terminally extended zinc finger structure which wraps around one turn of the DNA, a result which helps to set limits on the mechanism of nucleosome remodelling.

    • Christopher M. Read
    • Paul C. Driscoll
    News & Views
    Nature Structural Biology
    Volume: 4, P: 87-89

  • Classical type 1 dendritic cells (cDC1s) are essential for activation of antiviral and anticancer T cell responses. Murphy and colleagues describe a genetic circuit that involves the transcription factors Nfil3, Id2 and Zeb2. This circuit imposes a molecular switch that allows cDC1 specification and development.

    • Prachi Bagadia
    • Xiao Huang
    • Kenneth M. Murphy
    Research
    Nature Immunology
    Volume: 20, P: 1174-1185