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Showing 1–50 of 54 results

Advanced filters: Author: M. Romanos Clear advanced filters

SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors

Lightbody et al. present SWIFT-seq, a single-cell RNA sequencing approach to profile circulating tumor cells from patients with multiple myeloma and its precursor conditions and leverage it to derive clinical and biological insights into the disease.

Elizabeth D. Lightbody
Romanos Sklavenitis-Pistofidis
Irene M. Ghobrial
Research08 Aug 2025
Nature Cancer

Volume: 6, P: 1595-1611
Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia

The impact of tumor intrinsic and immune alterations on disease progression in patients with Waldenstrom’s Macroglobulinemia (WM) remains to be characterized. Here, the authors perform single-cell RNA-sequencing and identify distinct tumor subtypes, tumour microenvironment features and potential therapeutic vulnerabilities in patients with WM.

Romanos Sklavenitis-Pistofidis
Yoshinobu Konishi
Irene M. Ghobrial
ResearchOpen Access10 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Genomic landscape of multiple myeloma and its precursor conditions

The genomic features of precursor conditions of multiple myeloma provide multiple biological insights into disease origins and evolution, together with opportunities to identify those at highest risk of progression.

Jean-Baptiste Alberge
Ankit K. Dutta
Irene M. Ghobrial
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1493-1503
Protective Surface Antigen P69 of Bordetella pertussis: Its Characterization and Very High Level Expression in Escherichia coli

A. J. Makoff
M. D. Oxer
I. G. Charles
Research01 Nov 1990
Bio/Technology

Volume: 8, P: 1030-1033
Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial

Depth of response (CR/VGPR, MRD-) links to better outcomes, while biochemical progression predicts end-organ damage. Higher MHC-I on tumors and greater GZMB+ T cells in clonally expanded CD8+ T cells are tied to improved outcomes.

Omar Nadeem
Michelle P. Aranha
Irene M. Ghobrial
ResearchOpen Access03 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Recent Advances in the Expression of Foreign Genes in Pichia pastoris

James M. Cregg
Thomas S. Vedvick
William C. Raschke
Reviews01 Aug 1993
Bio/Technology

Volume: 11, P: 905-910
A human Mad protein acting as a BMP-regulated transcriptional activator

Fang Liu
Akiko Hata
Joan Massagué
Research13 Jun 1996
Nature

Volume: 381, P: 620-623
High-Level Expression of Tetanus Toxin Fragment C in Pichia Pastoris Strains Containing Multiple Tandem Integrations of the Gene

J. J. Clare
F. B. Rayment
M. A. Romanos
Research01 May 1991
Bio/Technology

Volume: 9, P: 455-460
Correction: Corrigendum: Multiple common variants for celiac disease influencing immune gene expression

Patrick C A Dubois
Gosia Trynka
David A van Heel
Amendments and Corrections01 May 2010
Nature Genetics

Volume: 42, P: 465
3-Oxothiolase Activities and [¹⁴C]-2-Methylbutanoic Acid Incorporation in Cultured Fibroblasts from 13 Cases of Suspected 3-Oxothiolase Deficiency

Pål Iden
Bruce Middleton
Oddmund Søvik
Research01 Nov 1990
Pediatric Research

Volume: 28, P: 518-522
Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes

Existing clinical models cannot fully capture smoldering multiple myeloma (SMM) heterogeneity. Here, integration of 42 genetic alterations from 214 SMM patients using an unsupervised binary matrix factorization clustering approach results in the identification of 6 distinct molecular and clinical subtypes.

Mark Bustoros
Shankara Anand
Irene M. Ghobrial
ResearchOpen Access15 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Ditte Demontis
Raymond K. Walters
Benjamin M. Neale
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 63-75
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential (CHIP) at time of ASCT is associated with adverse outcomes in MM patients.

Tarek H. Mouhieddine
Adam S. Sperling
Irene M. Ghobrial
ResearchOpen Access12 Jun 2020
Nature Communications

Volume: 11, P: 1-9
A High Capacity Assay for Inhibitors of Human Papillomavirus DNA Replication

Mary Plumpton
Nigel A. Sharp
Michael A. Romanos
Research01 Nov 1995
Bio/Technology

Volume: 13, P: 1210-1214
Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis

Development of multiple myeloma is preceded by precursor conditions. Here, the authors use single cell RNA-sequencing of plasma cells from patients across disease stages to identify genomic signatures present even at the earliest stages of disease.

Rebecca Boiarsky
Nicholas J. Haradhvala
Gad Getz
ResearchOpen Access17 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

Hakon Hakonarson and colleagues report a genome-wide copy number variation study in 3,506 cases of attention-deficit hyperactivity disorder. The authors identify a statistically significant enrichment of CNVs impacting metabotropic glutamate receptor genes.

Josephine Elia
Joseph T Glessner
Hakon Hakonarson
Research04 Dec 2011
Nature Genetics

Volume: 44, P: 78-84
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma

Ghobrial, Getz and colleagues characterize the changes in the tumor immune microenvironment associated with multiple myeloma progression.

Oksana Zavidij
Nicholas J. Haradhvala
Irene M. Ghobrial
Research27 Apr 2020
Nature Cancer

Volume: 1, P: 493-506
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Aggressive cerebral cavernous malformations (CCMs) are found to grow through a three-hit cancer-like mechanism, involving gain of function of a gene that promotes vascular growth, and loss of function of genes that suppress it.

Aileen A. Ren
Daniel A. Snellings
Mark L. Kahn
Research28 Apr 2021
Nature

Volume: 594, P: 271-276
Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder

Rinus Vegt
Aida M Bertoli-Avella
Ben A Oostra
Research26 Aug 2009
European Journal of Human Genetics

Volume: 18, P: 206-211
Inflammatory stromal cells in the myeloma microenvironment

Single-cell RNA sequencing identifies an inflammatory subpopulation of mesenchymal stromal cells in patients with multiple myeloma.

Romanos Sklavenitis-Pistofidis
Nicholas J. Haradhvala
Irene M. Ghobrial
News & Views20 May 2021
Nature Immunology

Volume: 22, P: 677-678
Newly identified genetic risk variants for celiac disease related to the immune response

Karen A Hunt
Alexandra Zhernakova
David A van Heel
Research02 Mar 2008
Nature Genetics

Volume: 40, P: 395-402
Multiple common variants for celiac disease influencing immune gene expression

David van Heel and colleagues report results of a large genome-wide association study of celiac disease. Most of the associated loci contain genes with immune functions, and over half harbor risk variants that are correlated with variation in cis gene expression.

Patrick C A Dubois
Gosia Trynka
David A van Heel
Research28 Feb 2010
Nature Genetics

Volume: 42, P: 295-302
Expression in Yeast of Amino-Terminal Peptide Fusions to Hepatitis B Core Antigen and Their Immunological Properties

K.M. Beesley
M.J. Francis
M.A. Romanos
Research01 Jul 1990
Bio/Technology

Volume: 8, P: 644-649
Association of DNA damage response signals and oxidative stress status with nivolumab efficacy in patients with Head and Neck Squamous Cell Carcinoma

Christina Papanikolaou
Panagiota Economopoulou
Amanda Psyrri
Research23 May 2025
British Journal of Cancer

Volume: 133, P: 353-364
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

David van Heel, Cisca Wijmenga and colleagues used a custom, high-density genotyping chip to examine 183 immune-related loci for their role in celiac disease. They report 13 new regions associated with celiac disease risk, identify multiple independent signals at several loci and refine the localization of many previously reported risk signals.

Gosia Trynka
Karen A Hunt
David A van Heel
Research06 Nov 2011
Nature Genetics

Volume: 43, P: 1193-1201
High–Level Expression of Human Lipocortin I in the Fission Yeast Schizosaccharomyces pombe Using a Novel Expression Vector

Yuko Giga-Hama
Hideki Tohda
Hiromichi Kumagai
Research01 Apr 1994
Bio/Technology

Volume: 12, P: 400-404
Helmets Labeling Crops: Kenya Crop Type Dataset Created via Helmet-Mounted Cameras and Deep Learning

Catherine Nakalembe
Ivan Zvonkov
Priscilla Mawuena Loh
ResearchOpen Access27 Aug 2025
Scientific Data

Volume: 12, P: 1-13
DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders

Andreas Reif
T Trang Nguyen
Klaus-Peter Lesch
Research13 Jul 2011
Neuropsychopharmacology

Volume: 36, P: 2318-2327
Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci

Ciara Coleman
Emma M Quinn
Ross McManus
ResearchOpen Access29 Apr 2015
European Journal of Human Genetics

Volume: 24, P: 291-297
A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD

M Jain
J I Vélez
M Muenke
ResearchOpen Access24 May 2011
Molecular Psychiatry

Volume: 17, P: 741-747
Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12

M Romanos
C Freitag
K P Lesch
Research26 Feb 2008
Molecular Psychiatry

Volume: 13, P: 522-530
Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree

K-P Lesch
S Selch
R Ullmann
Research23 Mar 2010
Molecular Psychiatry

Volume: 16, P: 491-503
Single-cell profiling of tumour evolution in multiple myeloma — opportunities for precision medicine

Multiple myeloma and its precursor stages, monoclonal gammopathy of undetermined significance and smouldering multiple myeloma, have a considerable degree of genetic heterogeneity. The authors of this Review discuss how single-cell studies in these individuals are enabling the mutational and phenotypic characterization of cells within the bone marrow tumour, immune microenvironment and peripheral blood to eventually guide early diagnosis, risk stratification and treatment strategies.

Ankit K. Dutta
Jean-Baptiste Alberge
Irene M. Ghobrial
Reviews11 Jan 2022
Nature Reviews Clinical Oncology

Volume: 19, P: 223-236
Dynamic molecular ordering in multiphasic nanoconfined ionic liquids detected with time-resolved diffusion NMR

Molecular motion in nanosized pores can be extremely complex. Here, NMR diffusion experiments in different relaxation windows and molecular dynamics simulations suggest an unusual dynamic molecular ordering when an ionic liquid is confined in nanoporous silica.

Marina Karagianni
Lydia Gkoura
Georgios Papavassiliou
ResearchOpen Access07 Feb 2023
Communications Materials

Volume: 4, P: 1-10
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

M Arcos-Burgos
M Jain
M Muenke
Research16 Feb 2010
Molecular Psychiatry

Volume: 15, P: 1053-1066
Acute lymphoblastic leukemia as a clonally unrelated second primary malignancy after multiple myeloma

Ibrahim Aldoss
Marzia Capelletti
Amrita Krishnan
Research19 Jul 2018
Leukemia

Volume: 33, P: 266-270
Individual differences in human fear generalization—pattern identification and implications for anxiety disorders

Y. Stegmann
M. A. Schiele
P. Pauli
ResearchOpen Access18 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-11
Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish—implications for neurodevelopmental disorders

Teresa M. Lüffe
Andrea D’Orazio
Christina Lillesaar
ResearchOpen Access14 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-12
UGT2B17 minor histocompatibility mismatch and clinical outcome after HLA-identical sibling donor stem cell transplantation

N Santos
R Rodríguez-Romanos
D Gallardo
Research14 Sept 2015
Bone Marrow Transplantation

Volume: 51, P: 79-82
A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

L. G. Hommers
J. Richter
J. Deckert
ResearchOpen Access19 Oct 2018
Translational Psychiatry

Volume: 8, P: 1-12
Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing

Jordi Corominas
Marieke Klein
Klaus-Peter Lesch
ResearchOpen Access16 Aug 2018
Molecular Psychiatry

Volume: 25, P: 2047-2057
Exploratory dietary patterns and cognitive function in the “Seguimiento Universidad de Navarra” (SUN) Prospective Cohort

M. I. Muñoz-García
M. A. Martínez-González
E. Toledo
Research13 May 2021
European Journal of Clinical Nutrition

Volume: 76, P: 48-55
Erratum: DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders

Andreas Reif
T Trang Nguyen
Helmut Schäfer
Amendments and Corrections13 Feb 2012
Neuropsychopharmacology

Volume: 37, P: 1076
Oral contraceptives use and development of obesity in a Mediterranean cohort: the SUN (Seguimiento Universidad de Navarra) Project

Alvaro San-Juan-Rodriguez
Maira Bes-Rastrollo
Alfredo Gea
Research29 Aug 2019
International Journal of Obesity

Volume: 44, P: 320-329
Association between periodontal disease and polycystic ovary syndrome: a systematic review

S V Kellesarian
V R Malignaggi
F Javed
Reviews09 Mar 2017
International Journal of Impotence Research

Volume: 29, P: 89-95
Dysregulation of autophagy in the central nervous system of sheep naturally infected with classical scrapie

Óscar López-Pérez
Alicia Otero
Inmaculada Martín-Burriel
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-14
Serotonergic modulation of ‘waiting impulsivity’ is mediated by the impulsivity phenotype in humans

S Neufang
A Akhrif
M Romanos
ResearchOpen Access08 Nov 2016
Translational Psychiatry

Volume: 6, P: e940
Association and linkage of allelic variants of the dopamine transporter gene in ADHD

S Friedel
K Saar
J Hebebrand
Research10 Apr 2007
Molecular Psychiatry

Volume: 12, P: 923-933
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

J Deckert
H Weber
A Reif
Research07 Feb 2017
Molecular Psychiatry

Volume: 22, P: 1431-1439
Psychiatric gene discoveries shape evidence on ADHD’s biology

A Thapar
J Martin
P Holmans
ResearchOpen Access17 Nov 2015
Molecular Psychiatry

Volume: 21, P: 1202-1207

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