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Showing 1–14 of 14 results
Advanced filters: Author: Magnus Unemo Clear advanced filters

  • Gonorrhoea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae that affects millions of people worldwide, and its incidence is increasing in many settings. The emergence and spread of antimicrobial resistance in N. gonorrhoeae threatens to leave affected individuals with no effective treatments.

    • Magnus Unemo
    • H Steven Seifert
    • Jo-Anne R. Dillon
    Reviews
    Nature Reviews Disease Primers
    Volume: 5, P: 1-23

  • Antimicrobial resistance in Neisseria gonorrhoeae compromises gonorrhoea treatment globally and vaccines might be the only sustainable solution for gonorrhoea control. A new study for the first time provides a proof of principle for protection with ∼31% effectiveness against gonorrhoea, owing to cross-protection by the outer membrane vesicle Neisseria meningitidis serogroup B vaccine (MeNZB).

    • Magnus Unemo
    • Aleksandra E. Sikora
    News & Views
    Nature Reviews Urology
    Volume: 14, P: 643-644

  • Gonorrhoea andMycoplasma genitaliuminfections are evolving to be exceedingly difficult to treat or untreatable. Unemo and Jensen provide an overview and discussion of prevalence data, diagnostics, current treatment recommendations and potential future therapies of these infections, highlighting priorities to retain their treatability.

    • Magnus Unemo
    • Jorgen S. Jensen
    Reviews
    Nature Reviews Urology
    Volume: 14, P: 139-152

  • In the Review, Jensen and Unemo examine the epidemiology and clinical features, treatment options, and antimicrobial resistance of Neisseria gonorrhoeae and Mycoplasma genitalium, while briefly covering Chlamydia trachomatis and Treponema pallidum.

    • Jorgen S. Jensen
    • Magnus Unemo
    Reviews
    Nature Reviews Microbiology
    Volume: 22, P: 435-450

  • Sexually transmitted infections (STIs) remain public health concerns. Doxycycline post-exposure prophylaxis to prevent STIs is a novel promising intervention, which in a new study caused an ∼65% reduction in incident STIs. However, long-term effects on STI prevalence, microbiomes and antimicrobial resistance among STI pathogens, non-STI pathogens and commensals need to be monitored.

    • Magnus Unemo
    • Fabian Yuh Shiong Kong
    News & Views
    Nature Reviews Urology
    Volume: 20, P: 522-523

  • Antimicrobial resistance in Neisseria gonorrhoeae compromises gonorrhoea treatment worldwide. Novel and optimized treatments and/or treatment strategies that effectively eradicate the infection with low selection of resistance are imperative. A new prospective clinical study provides further evidence that resistance-guided treatment of gonorrhoea with single-dose oral ciprofloxacin is efficacious in relevant settings and can reduce the selection pressure for resistance.

    • Magnus Unemo
    News & Views
    Nature Reviews Urology
    Volume: 17, P: 609-610

  • Antibiotic resistance in Neisseria gonorrhoeae is rising, yet sometimes strains emerge that have reverted to susceptibility. Here, the authors find that selective pressures from the host may influence susceptibility through loss-of-function mutations in genes that encode for efflux pumps.

    • Kevin C. Ma
    • Tatum D. Mortimer
    • Yonatan H. Grad
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Phylogeographical genomic analysis of Neisseria gonorrhoeae uncovers its recent emergence and current distribution into two distinct lineages that are differentially associated with antibiotic resistance and sexual networks.

    • Leonor Sánchez-Busó
    • Daniel Golparian
    • Simon R. Harris
    Research
    Nature Microbiology
    Volume: 4, P: 1941-1950

  • Simon Harris and colleagues report whole-genome sequencing of 36 Chlamydia trachomatis representative strains from temporally and geographically diverse sources and use this to construct a genome-wide phylogeny of the species. They find that epidemic spread can be driven by clonal expansion from a single source and also report evidence for recombination in recent clinical strains both within and between biovars.

    • Simon R Harris
    • Ian N Clarke
    • Nicholas R Thomson
    Research
    Nature Genetics
    Volume: 44, P: 413-419