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Showing 1–4 of 4 results
Advanced filters: Author: Manuel A. Podestà Clear advanced filters

  • Follicular helper T cells play critical roles in the formation of high affinity antibody responses, but the signals involved in the development of these cells after initial differentiation are poorly understood. Here Podestà, Cavazzoni and colleagues characterise transitionary phases of follicular helper T cell development and how progression through these stages is linked to humoral immunity.

    • Manuel A. Podestà
    • Cecilia B. Cavazzoni
    • Peter T. Sage
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Follicular regulatory T (Tfr) cells modulate germinal center T and B cell responses, but how Tfr may control allograft rejection is still unclear. Here the authors show, using mouse kidney allograft rejection models, that Tfr suppresses the production of pro-inflammatory cytokines and alloreactive antibodies from alloreactive B cells to dampen graft rejection

    • Hengcheng Zhang
    • Manuel A. Podestà
    • Peter T. Sage
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • TFH cells that express IL-13 are associated with high-affinity IgE responses, but factors controlling their development, transcriptional programming and exact function have remained unclear. Here, Chandrakar et al. find that the transcription factor JunB is required for TFH13 cell maintenance and that TFH13 cells producing IL-21 drive broad germinal center responses to allergen-specific IgG and IgE.

    • Pragya Chandrakar
    • Cody S. Nelson
    • Peter T. Sage
    Research
    Nature Immunology
    Volume: 26, P: 473-483

  • Podocytopathies are kidney diseases in which podocyte injury drives proteinuria or nephrotic syndrome. This Primer discusses a shift in paradigm from patient stratification based on kidney biopsy findings towards personalized management based on clinical, morphological and genetic data.

    • Jeffrey B. Kopp
    • Hans-Joachim Anders
    • Paola Romagnani
    Reviews
    Nature Reviews Disease Primers
    Volume: 6, P: 1-24