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Cardiomyocyte mitochondrial mono-ADP-ribosylation dictates cardiac tolerance to sepsis by configuring bioenergetic reserve in male mice

Effective treatments are lacking for sepsis-related heart failure, which involves severe impairment of heart cell metabolism. Here, the authors show that blocking the protein MacroD1 preserves cellular energy production and protects against heart failure in mouse models of sepsis.

Xiaoqiang Chen
Tianyou Yuan
Jun Li
ResearchOpen Access30 Aug 2025
Nature Communications

Volume: 16, P: 1-20
A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality

In a systematic review and meta-analysis of 90 prospective cohort studies, Wang et al. find a significant association of both social isolation and loneliness with increased risk of all-cause mortality.

Fan Wang
Yu Gao
Yashuang Zhao
Research19 Jun 2023
Nature Human Behaviour

Volume: 7, P: 1307-1319
Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia

Mechanistic insights reveal that cathepsin B dependent glycolysis regulates urate transporter expression, contributing to impaired renal uric acid excretion in hyperuricemia

Huagang Lin
Linjing Nie
Jing Xiao
ResearchOpen Access02 Jun 2025
Communications Biology

Volume: 8, P: 1-16

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