Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.
- Mercedes M. Pérez-Jiménez
- José M. Monje-Moreno
- Manuel J. Muñoz