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Local nutrient addition drives plant diversity losses but not biotic homogenization in global grasslands

A common but untested expectation is that nutrient enrichment causes biotic homogenization. However, a globally standardized nutrient addition experiment in grasslands shows proportionally similar species loss across scales and no biotic homogenization after up to 14 years of treatment.

Qingqing Chen
Shane A. Blowes
Jonathan M. Chase
ResearchOpen Access27 May 2025
Nature Communications

Volume: 16, P: 1-8
Discovery and quality analysis of a comprehensive set of structural variants and short tandem repeats

The complexity of structural variation (SV) and short tandem repeats (STRs) makes it necessary to apply different calling and filtering strategies to sequencing datasets. Here, Jakubosky et al. report a comprehensive SV and STR callset from whole-genome sequencing of 477 individuals from iPSCORE and HipSci using five algorithms.

David Jakubosky
Erin N. Smith
Kelly A. Frazer
ResearchOpen Access10 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Properties of structural variants and short tandem repeats associated with gene expression and complex traits

Genetic variation associated with gene expression changes has mostly been studied in the context of single nucleotide variants. Here, Jakubosky et al. report eQTL analysis of structural variants and short tandem repeats and find properties, such as length of variation, that affect the association.

David Jakubosky
Matteo D’Antonio
Kelly A. Frazer
ResearchOpen Access10 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Antigen experience history directs distinct functional states of CD8⁺ CAR T cells during the antileukemia response

Here, Fry and colleagues examine the impact of antigen experience on subsequent CD8⁺ CAR T cell activity during the antileukemia response and show that RUNX2 overexpression enhances antitumor activity of these cells.

Kole R. DeGolier
Etienne Danis
Terry J. Fry
ResearchOpen Access02 Jan 2025
Nature Immunology

Volume: 26, P: 68-81
Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells

Chen Yao
Guohua Lou
Tuoqi Wu
Amendments and Corrections03 Mar 2021
Nature Immunology

Volume: 22, P: 530
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics

Integrative data analysis of 1,367 human iPSC lines maps common and rare regulatory variants that colocalize with loci associated with human traits and diseases.

Marc Jan Bonder
Craig Smail
Oliver Stegle
Research04 Mar 2021
Nature Genetics

Volume: 53, P: 313-321
Widening global variability in grassland biomass since the 1980s

Remotely sensed NDVI data and contemporary field data from 84 grasslands on 6 continents show increasing divergence in aboveground plant biomass between sites in different bioclimatic regions.

Andrew S. MacDougall
Ellen Esch
Eric W. Seabloom
Research05 Aug 2024
Nature Ecology & Evolution

Volume: 8, P: 1877-1888
Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity

Lysophosphatidic acid is known to increase in concentration in multiple cancer types. Here, the authors show it affects CD8 T cell metabolism, phenotype, and effector functions, and plasma concentrations appear predictive of response to immunotherapy.

Jacqueline A. Turner
Malia A. Fredrickson
Raul M. Torres
ResearchOpen Access03 Jun 2023
Nature Communications

Volume: 14, P: 1-14
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells

Tuoqi Wu and colleagues show that the transcriptional repressor BACH2 is required early after chronic viral infection to enforce a stem-like fate in activated CD8⁺ T cells. BACH2 acts to suppress genes that lead to the exhausted cell state.

Chen Yao
Guohua Lou
Tuoqi Wu
Research11 Feb 2021
Nature Immunology

Volume: 22, P: 370-380
Author Correction: Widening global variability in grassland biomass since the 1980s

Andrew S. MacDougall
Ellen Esch
Eric W. Seabloom
Amendments and Corrections19 Aug 2024
Nature Ecology & Evolution

Volume: 8, P: 2003
Addition of multiple limiting resources reduces grassland diversity

Analysis of multi-year nutrient enrichment experiments carried out on 45 global grassland sites show that an addition of an increasing number of nutrients leads to a reduction in plant species diversity, and competition for multiple belowground resources promotes plant species diversity.

W. Stanley Harpole
Lauren L. Sullivan
Peter D. Wragg
Research24 Aug 2016
Nature

Volume: 537, P: 93-96
HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma

Blanca Gonzalez-Farre
Daniel Martinez
Antonio Martinez
Research13 Jan 2017
Modern Pathology

Volume: 30, P: 745-760

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