Karagyozova at al. reveal that the histone H3.3 chaperone HIRA impacts higher-order spatial arrangement of chromatin, independently from its role in regulating early replication, providing a model to disentangle long-standing correlations between early replication, accessibility, typical histone marks and A compartment.
- Tina Karagyozova
- Alberto Gatto
- Geneviève Almouzni