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Dysfunctional CD4 T cells in an oncovirus-specific TCR-transgenic in vivo model

Dysfunctionality of T lymphocytes has been implicated in cancer and infection, however, the role of CD4 T cells remains understudied. The authors here generate a TCR transgenic mouse model for the study of dysfunctional CD4 T cells directed against a tumor-specific antigen, which can be reinvigorated by checkpoint blockade and vaccination.

Felicia S. Spitzer
Marcel G. M. Camps
Ferry Ossendorp
ResearchOpen Access18 Dec 2025
Nature Communications

Volume: 17, P: 1-14
The interplay between stress, inflammation and Parkinson’s disease: insights from the COVID-19 pandemic

Anouk van der Heide
Brenda Kischkel
Rick C. Helmich
ResearchOpen Access21 Nov 2025
npj Parkinson's Disease

Volume: 11, P: 1-9
Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

Poeck and colleagues identify a microbiome signature in patients receiving allogenic stem cell transplantation, which is associated with protective immune-modulatory metabolites, improved survival and less transplant-related mortality.

Erik Thiele Orberg
Elisabeth Meedt
Hendrik Poeck
Research03 Jan 2024
Nature Cancer

Volume: 5, P: 187-208
An emerging biomarker for dopaminergic cell loss

A recent publication in Nature Aging suggests that DOPA decarboxylase may serve as an emerging biomarker that can identify neurodegenerative disorders that are characterized by dopaminergic cell loss. Here we discuss how this finding can assist clinicians and researchers in the differential diagnosis of individuals who present with parkinsonism or cognitive decline.

Marcel M. Verbeek
Bastiaan R. Bloem
News & Views21 Sept 2023
Nature Aging

Volume: 3, P: 1180-1182
Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase

Anouke van Rumund
Lukas Pavelka
Marcel M. Verbeek
ResearchOpen Access19 Mar 2021
npj Parkinson's Disease

Volume: 7, P: 1-5
Newly identified genetic risk variants for celiac disease related to the immune response

Karen A Hunt
Alexandra Zhernakova
David A van Heel
Research02 Mar 2008
Nature Genetics

Volume: 40, P: 395-402
Cerebrospinal fluid monocyte chemoattractant protein 1 correlates with progression of Parkinson’s disease

Anna Santaella
H. Bea Kuiperij
Marcel M. Verbeek
ResearchOpen Access03 Sept 2020
npj Parkinson's Disease

Volume: 6, P: 1-5
Insights into the expanding phenotypic spectrum of inherited disorders of biogenic amines

Inherited disorders of neurotransmitter metabolism represent a group of rare neurometabolic diseases characterized by movement disorders and developmental delay. Here, the authors report a standardized evaluation of a registry of 275 patients from 42 countries, and highlight an evolving phenotypic spectrum of this disease group and factors influencing diagnostic processes.

Oya Kuseyri Hübschmann
Gabriella Horvath
Thomas Opladen
ResearchOpen Access20 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Identification of cerebrospinal fluid biomarkers for parkinsonism using a proteomics approach

Tainá M. Marques
Anouke van Rumund
Marcel M. Verbeek
ResearchOpen Access30 Nov 2021
npj Parkinson's Disease

Volume: 7, P: 1-11
Immunogenicity of rat-neu⁺ mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment

Heng Sheng Sow
Hreinn Benonisson
J. Sjef Verbeek
ResearchOpen Access03 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Upstream SLC2A1 translation initiation causes GLUT1 deficiency syndrome

Michèl A Willemsen
Lisenka ELM Vissers
Erik-Jan Kamsteeg
Research05 Apr 2017
European Journal of Human Genetics

Volume: 25, P: 771-774
Neural networks for increased accuracy of allergenic pollen monitoring

Marcel Polling
Chen Li
Barbara Gravendeel
ResearchOpen Access31 May 2021
Scientific Reports

Volume: 11, P: 1-10
Factors associated with mortality in early stages of parkinsonism

Anouke van Rumund
Rianne A. J. Esselink
Marcel M. Verbeek
ResearchOpen Access02 Jun 2022
npj Parkinson's Disease

Volume: 8, P: 1-8
Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing

Jordi Corominas
Marieke Klein
Klaus-Peter Lesch
ResearchOpen Access16 Aug 2018
Molecular Psychiatry

Volume: 25, P: 2047-2057
Mechanisms of peripheral levodopa resistance in Parkinson’s disease

Milan Beckers
Bastiaan R. Bloem
Marcel M. Verbeek
ReviewsOpen Access11 May 2022
npj Parkinson's Disease

Volume: 8, P: 1-9
DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders

Andreas Reif
T Trang Nguyen
Klaus-Peter Lesch
Research13 Jul 2011
Neuropsychopharmacology

Volume: 36, P: 2318-2327

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Dysfunctional CD4 T cells in an oncovirus-specific TCR-transgenic in vivo model

The interplay between stress, inflammation and Parkinson’s disease: insights from the COVID-19 pandemic

Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

An emerging biomarker for dopaminergic cell loss

Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase

Newly identified genetic risk variants for celiac disease related to the immune response

Cerebrospinal fluid monocyte chemoattractant protein 1 correlates with progression of Parkinson’s disease

Insights into the expanding phenotypic spectrum of inherited disorders of biogenic amines

Identification of cerebrospinal fluid biomarkers for parkinsonism using a proteomics approach

Immunogenicity of rat-neu⁺ mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment

Upstream SLC2A1 translation initiation causes GLUT1 deficiency syndrome

Neural networks for increased accuracy of allergenic pollen monitoring

Factors associated with mortality in early stages of parkinsonism

Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing

Mechanisms of peripheral levodopa resistance in Parkinson’s disease

DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders

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