Nature Search

One millennium of historical freshwater fish occurrence data for Portuguese rivers and streams

Gonçalo Duarte
Miguel Moreira
Pedro Segurado
ResearchOpen Access14 Aug 2018
Scientific Data

Volume: 5, P: 1-8
Mapping residual water fluoride levels and geological patterns in a rural semi-arid area of Brazil

Marcos Alexandre Casimiro de Oliveira
Alexandre Almeida Júnior
Fábio Correia Sampaio
ResearchOpen Access23 Oct 2025
Scientific Reports

Volume: 15, P: 1-8
Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response

The immune response to tumour development is frequently targeted with therapeutics but remains largely unexplored in diagnostics. Here this groups designs an immunodiagnostic platform targeting amino acid residue biomarkers associated with tumour development and distinct from autoimmune and infectious diseases.

Cong Tang
Patrícia Corredeira
Gonçalo J. L. Bernardes
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal

An analysis of viral genomes and epidemiological data from the 2022 mpox outbreak in Portugal sheds light on the heterogeneity of early transmission events, with national and international linkages.

Vítor Borges
Mariana Perez Duque
João Paulo Gomes
ResearchOpen Access11 Sept 2023
Nature Medicine

Volume: 29, P: 2509-2517
Indirect protection and long-term effectiveness of inactivated COVID-19 vaccine: a stepped-wedge randomised trial in Serrana, Brazil

Marcos Carvalho Borges
Ricardo Palacios
Fernanda Castro Boulos
ResearchOpen Access19 Feb 2026
Scientific Reports

P: 1-12
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
The resilience of vaccine serotypes in adult invasive pneumococcal disease in Portugal, 2018–2023

Andreia Guerreiro-Nunes
Catarina Silva-Costa
Ana Helena Correia
ResearchOpen Access17 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Borges et al. study the dynamics of SARS-CoV-2 in Portugal during 2020. The authors use phylodynamic modelling to infer patterns of SARS-CoV-2 introduction into Portugal and its subsequent spread, providing a comprehensive genomic epidemiology study of the early SARS-CoV-2 epidemic in Portugal.

Vítor Borges
Joana Isidro
João Paulo Gomes
ResearchOpen Access28 Jan 2022
Communications Medicine

Volume: 2, P: 1-11
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Integrating in situ strategies and molecular genetics for the conservation of the endangered Azorean endemic plant Lotus azoricus

Rúben M. Correia Rego
Luís Silva
Mónica Moura
ResearchOpen Access22 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
The genomic history of Iberian horses since the last Ice Age

Horses have lived in Iberia since the Ice Age. Using ancient genomes to study their history, Lira Garrido et al. reveal a local wild lineage lasting until Late Iron Age, and highlight the far-reaching influence of Iberian bloodlines across Europe and north Africa during the Iron Age and beyond.

Jaime Lira Garrido
Gaétan Tressières
Ludovic Orlando
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Variation in wood density across South American tropical forests

Wood density is a key control on tree biomass, and understanding its spatial variation improves estimates of forest carbon stock. Sullivan et al. measure >900 forest plots to quantify wood density and produce high resolution maps of its variation across South American tropical forests.

Martin J. P. Sullivan
Oliver L. Phillips
Joeri A. Zwerts
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012–2015)

Catarina Silva-Costa
Maria J. Brito
Isabel Monteiro
ResearchOpen Access09 Jan 2019
Scientific Reports

Volume: 9, P: 1-9
Analysis of the maternal inheritance hypothesis of the exochorium in eggs from hybrids of Chagas disease vectors

Paulo Sergio de Sousa
Jader de Oliveira
Kaio Cesar Chaboli Alevi
ResearchOpen Access06 Jan 2024
Scientific Reports

Volume: 14, P: 1-10
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression

Moreno-Loaiza et al. found that interleukin-1β, acting upon cardiac resident macrophages, promotes atrial fibrillation in mice, and this mechanism may represent a common pathway connecting various risk factors to this arrhythmia.

Oscar Moreno-Loaiza
Vinicius Cardoso Soares
Emiliano Medei
Research06 Feb 2025
Nature Cardiovascular Research

Volume: 4, P: 312-329
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

Some strains of Mycobacterium tuberculosis seem to be able to avoid host defense systems. Here the authors stratify patients by severity of tuberculosis and find correlations with the level of IL-1β production by macrophages exposed to these isolates.

Jeremy Sousa
Baltazar Cá
Margarida Saraiva
ResearchOpen Access23 Apr 2020
Nature Communications

Volume: 11, P: 1-14
The Metabolic Effects and Effectiveness of the Different Reconstruction Methods used in Gastric Cancer Surgery: A Systematic Review and Meta-Analysis

Maria Pinho Costa
Hugo Santos-Sousa
Bernardo Sousa-Pinto
ResearchOpen Access08 Oct 2024
Scientific Reports

Volume: 14, P: 1-13
The Beaker phenomenon and the genomic transformation of northwest Europe

Genome-wide data from 400 individuals indicate that the initial spread of the Beaker archaeological complex between Iberia and central Europe was propelled by cultural diffusion, but that its spread into Britain involved a large-scale migration that permanently replaced about ninety per cent of the ancestry in the previously resident population.

Iñigo Olalde
Selina Brace
David Reich
Research21 Feb 2018
Nature

Volume: 555, P: 190-196
Neurotransmitters’ white matter mapping unveils the neurochemical fingerprints of stroke

Neurotransmitters play a key role in brain function. Here, an MRI atlas of neurotransmitter circuits was developed to map stroke pre- and postsynaptic disruptions.

Pedro Nascimento Alves
Victor Nozais
Michel Thiebaut de Schotten
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-18
Current management of inherited retinal degenerations in Portugal (IRD-PT survey)

João Pedro Marques
Nuno Ferreira
Eduardo Silva
ResearchOpen Access14 Sept 2024
Scientific Reports

Volume: 14, P: 1-10
Designed endocytosis-inducing proteins degrade targets and amplify signals

Computationally designed genetically encoded proteins can be used to target surface proteins, thereby triggering endocytosis and subsequent intracellular degradation, activating signalling or increasing cellular uptake in specific tissues.

Buwei Huang
Mohamad Abedi
David Baker
ResearchOpen Access25 Sept 2024
Nature

Volume: 638, P: 796-804
Population genomics of post-glacial western Eurasia

An analysis involving the shotgun sequencing of more than 300 ancient genomes from Eurasia reveals a deep east–west genetic divide from the Black Sea to the Baltic, and provides insight into the distinct effects of the Neolithic transition on either side of this boundary.

Morten E. Allentoft
Martin Sikora
Eske Willerslev
ResearchOpen Access10 Jan 2024
Nature

Volume: 625, P: 301-311
Potential and limitations of machine meta-learning (ensemble) methods for predicting COVID-19 mortality in a large inhospital Brazilian dataset

Bruno Barbosa Miranda de Paiva
Polianna Delfino Pereira
Milena Soriano Marcolino
ResearchOpen Access01 Mar 2023
Scientific Reports

Volume: 13, P: 1-18
Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020

João M. Furtado
Jost B. Jonas
Rupert R. A. Bourne
ResearchOpen Access04 Jul 2024
Eye

Volume: 38, P: 2070-2082
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

In a post-approval study including more than 17,000 patients on the safety of pulsed field ablation, a new method for treatment of atrial fibrillation, the procedure was found to have a low rate of adverse events but was associated with some unexpected rare complications that will need further study.

Emmanuel Ekanem
Petr Neuzil
Vivek Y. Reddy
ResearchOpen Access08 Jul 2024
Nature Medicine

Volume: 30, P: 2020-2029
Lenstar LS 900 versus Pentacam-AXL: analysis of refractive outcomes and predicted refraction

Henrique Aragão Arruda
Joana M. Pereira
João C. Sousa
ResearchOpen Access14 Jan 2021
Scientific Reports

Volume: 11, P: 1-5
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

José Luis Cabrera-Alarcon
Raquel Cruz
José Antonio Enriquez
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-12
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality.

Luis A. Pérez-Jurado
Alejandro Cáceres
Juan R. González
ResearchOpen Access19 Feb 2024
Communications Biology

Volume: 7, P: 1-14
Comparative analysis of the bronchoalveolar microbiome in Portuguese patients with different chronic lung disorders

Susana Seixas
Allison R. Kolbe
Marcos Pérez-Losada
ResearchOpen Access22 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Natural enamel caries, dentine reactions, dentinal fluid and biofilm

Laryssa de Barros Pinto
Maria Luiza Lima Alves Lira
Frederico Barbosa de Sousa
ResearchOpen Access26 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
Prognostic impact of left ventricular reverse remodeling after surgical aortic valve replacement in severe aortic stenosis

Maria Rita Lima
João Abecasis
Nuno Cardim
ResearchOpen Access22 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Publisher Correction: Population genomics of post-glacial western Eurasia

Morten E. Allentoft
Martin Sikora
Eske Willerslev
Amendments and CorrectionsOpen Access18 Jan 2024
Nature

Volume: 626, P: E3
Serological surveillance of orally acquired acute Chagas disease in the Brazilian Amazon using conventional and in house assays

Susan Smith-Doria
Jorge Augusto de Oliveira Guerra
Maria das Graças Vale Barbosa Guerra
ResearchOpen Access14 Oct 2025
Scientific Reports

Volume: 15, P: 1-10
Engineering cell-based ovarian hormone therapy

Biomimetic endocrine implants bridge tissue engineering and reproductive medicine to offer adaptive and long-lasting hormone therapies for the treatment of ovarian premature insufficiency and menopause. Their clinical translation requires aligned regulatory, ethical and manufacturing pathways.

Maria João Sousa
Christiani A. Amorim
Comments & Opinion05 Jun 2025
Nature Reviews Bioengineering

Volume: 3, P: 620-622
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

Mark H. T. Stappers
Alexandra E. Clark
Gordon D. Brown
Research28 Feb 2018
Nature

Volume: 555, P: 382-386
BrtB is an O-alkylating enzyme that generates fatty acid-bartoloside esters

O-alkylation of carboxylates by alkyl halides has only been observed transiently in enzymatic processes. Here, the authors show a carboxylate alkylating enzyme, BrtB, that catalyzes C-O bond formation between free fatty acids and secondary alkyl chlorides.

João P. A. Reis
Sandra A. C. Figueiredo
Pedro N. Leão
ResearchOpen Access19 Mar 2020
Nature Communications

Volume: 11, P: 1-9
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
ResearchOpen Access07 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1063-1074
The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

Ann M. Mc Cartney
Giulio Formenti
Camila J. Mazzoni
ResearchOpen Access17 Sept 2024
npj Biodiversity

Volume: 3, P: 1-17
The extent of postpartum cardiac reverse remodeling is reflected in urine proteome

Ana F. Ferreira
Fábio Trindade
António S. Barros
ResearchOpen Access27 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Thrombophilic risk factors for retinal vein occlusion

Maria J. Vieira
António Campos
João P. Sousa
ResearchOpen Access12 Dec 2019
Scientific Reports

Volume: 9, P: 1-6
Molecular diagnosis of Huntington disease in Portugal: implications for genetic counselling and clinical practice

Maria do Carmo Costa
Paula Magalhães
Jorge Sequeiros
Research22 Oct 2003
European Journal of Human Genetics

Volume: 11, P: 872-878
Interaction of the Receptor for Advanced Glycation End Products (RAGE) with Transthyretin Triggers Nuclear Transcription Factor kB (NF-kB) Activation

Mónica Mendes Sousa
Shi Du Yan
Maria João Saraiva
Research01 Jul 2000
Laboratory Investigation

Volume: 80, P: 1101-1110
Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men’s seminal quality

Joana Vieira Silva
Daniel Cruz
Margarida Fardilha
ResearchOpen Access03 Apr 2017
Scientific Reports

Volume: 7, P: 1-8
Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

Chikungunya virus is endemic in Brazil and cases have been rapidly increasing in recent years. Here, the authors describe the expansion of a genomic surveillance program across the country allowing them to characterise the emergence and dispersal of two distinct subclades mainly seeded from the north eastern region.

Joilson Xavier
Luiz Carlos Junior Alcantara
Marta Giovanetti
ResearchOpen Access21 Jul 2023
Nature Communications

Volume: 14, P: 1-12
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253

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