Nature Search

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis

Ciofani and colleagues examine the plasticity of Tγδ17 cells in the gut, where they identify a role for the AP-1 transcription factors JUNB and FOSL2 in restricting type 1 plasticity.

Morgan E. Parker
Naren U. Mehta
Maria Ciofani
Research27 Jun 2025
Nature Immunology

Volume: 26, P: 1299-1314
Structural changes in intestinal enteroendocrine cells after ileal interposition in normal rats

Aparecida Hirata
Rudy Rocha
Maria Alves
ResearchOpen Access12 Dec 2011
Nature Precedings

P: 1
Global chromatin conformation differences in the Drosophila dosage compensated chromosome X

In Drosophila, dosage compensation involves a twofold transcriptional upregulation of the single male chromosome X. Here the authors show that global conformational differences are specifically present in the male X chromosome and detectable using Hi-C data, indicating that dosage compensation affects global chromosome structure.

Koustav Pal
Mattia Forcato
Francesco Ferrari
ResearchOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1-16
Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

Clare Bailey
Clemens Lange
Vasileios Konidaris
ResearchOpen Access16 Jan 2026
Eye

P: 1-4
Colorectal cancer after bariatric surgery (Cric-Abs 2020): Sicob (Italian society of obesity surgery) endorsed national survey

Maria Chiara Ciccioriccio
Angelo Iossa
Marco Antonio Zappa
Research19 Jul 2021
International Journal of Obesity

Volume: 45, P: 2527-2531
Actomyosin-driven force patterning controls endocytosis at the immune synapse

The immune synapse promotes cellular information exchange but the role of biophysical forces in synapse function is unclear. Here, the authors show that B cells exert two types of forces, a centripetal myosin II-driven force and a central actin protrusive force at the site of antigen extraction.

Anita Kumari
Judith Pineau
Paolo Pierobon
ResearchOpen Access28 Jun 2019
Nature Communications

Volume: 10, P: 1-14
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

The molecular mechanisms underlying direct neuronal reprogramming are unclear. Here the authors show Ngn2-mediated chromatin remodeling and its binding sites underlying mouse astrocyte-to-neuron reprogramming and identify Yy1, a transcription co-factor, as an important regulator.

Allwyn Pereira
Jeisimhan Diwakar
Magdalena Götz
ResearchOpen Access02 Jul 2024
Nature Neuroscience

Volume: 27, P: 1260-1273
Emergence of replication timing during early mammalian development

Genome-wide replication timing maps of mouse embryos from the zygote to the blastocyst stage were generated using single-cell Repli-seq, shedding light on the establishment of the epigenome at the beginning of mammalian development.

Tsunetoshi Nakatani
Tamas Schauer
Maria-Elena Torres-Padilla
ResearchOpen Access20 Dec 2023
Nature

Volume: 625, P: 401-409
Cellular development and evolution of the mammalian cerebellum

Single-nucleus RNA-sequencing data from the cerebellum of human, mouse and opossum is used to analyse the developmental dynamics of cell types and states in mammalian cerebellum and provide evolutionary insights.

Mari Sepp
Kevin Leiss
Henrik Kaessmann
ResearchOpen Access29 Nov 2023
Nature

Volume: 625, P: 788-796
Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction

During cell adhesion, integrins are typically thought to require immobilized ligands for spreading. Here, the authors demonstrate that cells can spread and form mature integrin adhesions on fluid substrates by interacting with high-affinity Invasin ligands.

Oleg Mikhajlov
Ram M. Adar
Patricia Bassereau
ResearchOpen Access31 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Inhibition of USP10 induces degradation of oncogenic FLT3

An inhibitor of the deubiquitinase (DUB) USP10 regulates the degradation of oncogenic FLT3, thus defining USP10 as a DUB for FLT3 and providing a therapeutic approach for human acute myeloid leukemia in which FLT3 activation is dysregulated.

Ellen L Weisberg
Nathan J Schauer
Sara J Buhrlage
Research02 Oct 2017
Nature Chemical Biology

Volume: 13, P: 1207-1215
Accelerating inhibitor discovery for deubiquitinating enzymes

Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and a first-in-class VCPIP1 probe with nanomolar potency.

Wai Cheung Chan
Xiaoxi Liu
Sara J. Buhrlage
ResearchOpen Access08 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Temporal dynamics of the multi-omic response to endurance exercise training

Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

David Amar
Nicole R. Gay
Elena Volpi
ResearchOpen Access01 May 2024
Nature

Volume: 629, P: 174-183
The impact of exercise on gene regulation in association with complex trait genetics

It is known that exercise influences many human traits, but not which tissues and genes are most important. This study connects transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium with human data to identify traits with similar tissue specific gene expression signatures to exercise.

Nikolai G. Vetr
Nicole R. Gay
Stephen B. Montgomery
ResearchOpen Access01 May 2024
Nature Communications

Volume: 15, P: 1-14
A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells

Analyzing memory B cell repertoires of the healthy elderly enabled Michalon et al. to develop a recombinant human antibody selective for transthyretin amyloid. This antibody removes cardiac amyloid through recruitment of phagocytic immune cells.

Aubin Michalon
Andreas Hagenbuch
Jan Grimm
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-12
A new cholesterol derivative suitable for transfecting certain type of cells in the presence of 10% serum

Aleksander Sochanik
Irina Kaida
Stanisław Szala
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 513-520
Genome–lamina interactions are established de novo in the early mouse embryo

Spatial genome organization into lamina-associated domains is first established in the mouse zygote immediately after fertilization without inheritance from the maternal germline—with the paternal and maternal pronucleus exhibiting different organization, which subsequently converges prior to implantation of the embryo.

Máté Borsos
Sara M. Perricone
Jop Kind
Research22 May 2019
Nature

Volume: 569, P: 729-733
Combined network analysis and machine learning allows the prediction of metabolic pathways from tomato metabolomics data

David Toubiana et al. report the combination of correlation-based network analysis and machine-learning techniques to detect metabolic pathways from quantitative metabolic data. They demonstrate the utility of their method by studying metabolic pathways in tomato.

David Toubiana
Rami Puzis
Yuval Elovici
ResearchOpen Access18 Jun 2019
Communications Biology

Volume: 2, P: 1-13
INOVATYON/ ENGOT-ov5 study: Randomized phase III international study comparing trabectedin/pegylated liposomal doxorubicin (PLD) followed by platinum at progression vs carboplatin/PLD in patients with recurrent ovarian cancer progressing within 6-12 months after last platinum line

N. Colombo
A. Gadducci
Alexander Reinthaller
ResearchOpen Access09 Feb 2023
British Journal of Cancer

Volume: 128, P: 1503-1513
Epigenome dynamics in early mammalian embryogenesis

Upon fertilization and during early mammalian development, major changes in cellular plasticity occur. This is accompanied by large-scale epigenome remodelling, as has been recently highlighted by the application of genomics techniques to this developmental period.

Adam Burton
Maria-Elena Torres-Padilla
Reviews03 Apr 2025
Nature Reviews Genetics

Volume: 26, P: 587-603
The carboxy-terminus of IκBα determines susceptibility to degradation by the catalytic core of the proteasome

Mathias Kroll
Mariangela Conconi
Manuel S Rodriguez
Research09 Oct 1997
Oncogene

Volume: 15, P: 1841-1850
Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Jochen Gaedcke
Malte Sahrhage
H. Leber
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Perovskite oxides for visible-light-absorbing ferroelectric and photovoltaic materials

Most known ferroelectric photovoltaic materials have very wide electronic bandgaps (that is, they absorb only high-energy photons) but here a family of perovskite oxides is described that have tunable bandgaps, allowing their use across the whole visible-light spectrum.

Ilya Grinberg
D. Vincent West
Andrew M. Rappe
Research10 Nov 2013
Nature

Volume: 503, P: 509-512
Expression of DNA repair genes and its relevance for DNA repair in peripheral immune cells of patients with posttraumatic stress disorder

Alexander Behnke
Matthias Mack
Iris-Tatjana Kolassa
ResearchOpen Access04 Nov 2022
Scientific Reports

Volume: 12, P: 1-8
Origin and spread of human mitochondrial DNA haplogroup U7

Hovhannes Sahakyan
Baharak Hooshiar Kashani
Richard Villems
ResearchOpen Access07 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Natural occurrence of microbial sulphur oxidation by long-range electron transport in the seafloor

Sairah Y Malkin
Alexandra MF Rao
Filip JR Meysman
ResearchOpen Access27 Mar 2014
The ISME Journal

Volume: 8, P: 1843-1854
Sunlight modulates the relative importance of heterotrophic bacteria and picophytoplankton in DMSP-sulphur uptake

Clara Ruiz-González
Rafel Simó
Josep M Gasol
Research29 Sept 2011
The ISME Journal

Volume: 6, P: 650-659
Fryns syndrome: Report of eight new cases

Anne M Slavotinek
Galen Schauer
Roberta Keller
Correspondence01 Jan 2005
Genetics in Medicine

Volume: 7, P: 74-76

Search

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis

Structural changes in intestinal enteroendocrine cells after ileal interposition in normal rats

Global chromatin conformation differences in the Drosophila dosage compensated chromosome X

Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

Colorectal cancer after bariatric surgery (Cric-Abs 2020): Sicob (Italian society of obesity surgery) endorsed national survey

Actomyosin-driven force patterning controls endocytosis at the immune synapse

Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

Emergence of replication timing during early mammalian development

Cellular development and evolution of the mammalian cerebellum

Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction

Inhibition of USP10 induces degradation of oncogenic FLT3

Accelerating inhibitor discovery for deubiquitinating enzymes

Temporal dynamics of the multi-omic response to endurance exercise training

The impact of exercise on gene regulation in association with complex trait genetics

A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells

A new cholesterol derivative suitable for transfecting certain type of cells in the presence of 10% serum

Genome–lamina interactions are established de novo in the early mouse embryo

Combined network analysis and machine learning allows the prediction of metabolic pathways from tomato metabolomics data

INOVATYON/ ENGOT-ov5 study: Randomized phase III international study comparing trabectedin/pegylated liposomal doxorubicin (PLD) followed by platinum at progression vs carboplatin/PLD in patients with recurrent ovarian cancer progressing within 6-12 months after last platinum line

Epigenome dynamics in early mammalian embryogenesis

The carboxy-terminus of IκBα determines susceptibility to degradation by the catalytic core of the proteasome

Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Perovskite oxides for visible-light-absorbing ferroelectric and photovoltaic materials

Expression of DNA repair genes and its relevance for DNA repair in peripheral immune cells of patients with posttraumatic stress disorder

Origin and spread of human mitochondrial DNA haplogroup U7

Natural occurrence of microbial sulphur oxidation by long-range electron transport in the seafloor

Sunlight modulates the relative importance of heterotrophic bacteria and picophytoplankton in DMSP-sulphur uptake

Fryns syndrome: Report of eight new cases

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