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Showing 1–50 of 80 results

Advanced filters: Author: Maria Vinci Clear advanced filters

CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors

Chen at al. show that CHD1 loss in SPOP-mutated prostate tumors confers castration resistance by increasing SREBP2-mediated cholesterol synthesis and subsequent androgen supply, an effect counteracted by combined androgen and cholesterol inhibition.

Feiyu Chen
Haoyan Li
Di Zhao
Research13 May 2025
Nature Cancer

Volume: 6, P: 854-873
A new approach to the spatio-temporal pattern identification in neuronal multi-electrode registrations

Federico Esposti
Jacopo Lamanna
Maria Gabriella Signorini
ResearchOpen Access12 Nov 2007
Nature Precedings

P: 1
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to accumulation of proteins aggregates in airways. Mutated CFTR promotes transglutaminases-mediated crosslinking of beclin 1, a positive regulator of autophagy, to induce accumulation of LC3-binding protein p62 and prevent autophagic degradation of aggregates.

Alessandro Luciani
Valeria Rachela Villella
Luigi Maiuri
Research15 Aug 2010
Nature Cell Biology

Volume: 12, P: 863-875
Dynamic assessment of listening effort by EEG alpha oscillations during an adaptive speech-in-noise test

Davide Simeone
Edoardo Maria Polo
Alessia Paglialonga
ResearchOpen Access02 Oct 2025
Scientific Reports

Volume: 15, P: 1-11
Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting

Targeting of diseased cells is key to the development of next-generation pharmaceuticals, but is often hindered by a lack of specific cell surface markers. Here the authors develop an RNA-based approach, which allows precise control of gene expression, with translation only occurring within preselected cell types of interest.

Frederik Rastfeld
Marco Hoffmann
Bernd Hoffmann
ResearchOpen Access06 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Visceral adipose tissue adiponectin predicts excess weight loss after bariatric surgery in females with severe obesity

Giulia Cantini
Giovanni Quartararo
Michaela Luconi
Research03 Nov 2023
International Journal of Obesity

Volume: 48, P: 247-253
A hybrid bioorganic interface for neuronal photoactivation

Interfacing neurons with artificial functional materials could aid the development of neurological prosthetic devices. Here, primary neurons are incorporated into a polymer layer without adversely affecting their properties; the advance may contribute to the development of artificial retinas.

Diego Ghezzi
Maria Rosa Antognazza
Guglielmo Lanzani
Research25 Jan 2011
Nature Communications

Volume: 2, P: 1-7
Uncovering the mode of action of engineered T cells in patient cancer organoids

The dynamics and molecular mechanisms of T cell therapies are probed in cancer organoids.

Johanna F. Dekkers
Maria Alieva
Anne C. Rios
ResearchOpen Access25 Jul 2022
Nature Biotechnology

Volume: 41, P: 60-69
In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids

MISCOs are spatially arranged ventral midbrain–striatum–cortical organoids that enable investigations into the human dopaminergic system.

Daniel Reumann
Christian Krauditsch
Jürgen A. Knoblich
ResearchOpen Access05 Dec 2023
Nature Methods

Volume: 20, P: 2034-2047
The impact of radical prostatectomy on global climate: a prospective multicentre study comparing laparoscopic versus robotic surgery

Andrea Fuschi
Antonio Luigi Pastore
Antonio Carbone
Research21 Apr 2023
Prostate Cancer and Prostatic Diseases

Volume: 27, P: 272-278
Impact of transperitoneal anterior, retzius-sparing, extraperitoneal, transvesical and perineal approaches on urinary continence recovery after robot-assisted radical prostatectomy: a systematic review and meta-analysis of comparative studies

Vincenzo Ficarra
Marta Rossanese
Ettore Di Trapani
Reviews10 Feb 2025
Prostate Cancer and Prostatic Diseases

Volume: 28, P: 328-341
Hospital costs of robotic-assisted and open treatment of large ventral hernias

Flaminia Sabbatini
Davide La Regina
Francesco Mongelli
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-7
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases

Evan Eichler and colleagues use single-molecule molecular-inversion probes to sequence the coding and splicing regions of 208 candidate genes in more than 11,730 individuals with neurodevelopmental disorders. They report 91 genes with an excess of de novo or private disruptive mutations, identify 25 genes showing a bias for autism versus intellectual disability, and highlight a network associated with high-functioning autism.

Holly A F Stessman
Bo Xiong
Evan E Eichler
Research13 Feb 2017
Nature Genetics

Volume: 49, P: 515-526
Enhanced Lung Maturation in Cocaine-Exposed Rabbit Fetuses

Zeev N Kain
Mala R Chinoy
Emile M Scarpelli
Research01 Jun 1991
Pediatric Research

Volume: 29, P: 534-537
Control of structural flexibility of layered-pillared metal-organic frameworks anchored at surfaces

Understanding the structural dynamics of flexible metal-organic frameworks at a thin-film level is key if they are to be implemented in devices. Here, Fischer and colleagues anchor flexible MOF crystallites onto substrates and identify a structural responsiveness that is distinct to that of the bulk.

Suttipong Wannapaiboon
Andreas Schneemann
Roland A. Fischer
ResearchOpen Access21 Jan 2019
Nature Communications

Volume: 10, P: 1-10
Birefringence-induced phase delay enables Brillouin mechanical imaging in turbid media

Non-contact Brillouin microscopy holds potential to disrupt mechanobiology, yet this method faces challenges in presence of strong Rayleigh scattering. Here, the authors introduce a common-path birefringent filter exhibiting ultra-high extinction ratio to investigate turbid biological samples.

Giuseppe Antonacci
Renzo Vanna
Giulio Cerullo
ResearchOpen Access19 Jun 2024
Nature Communications

Volume: 15, P: 1-10
Organic and inorganic geochemical cyclicity of a Maastrichtian oceanic open-shelf carbonate source rock

Muhammad Usman
Maria Ardila-Sanchez
Volker Vahrenkamp
ResearchOpen Access08 May 2025
Scientific Reports

Volume: 15, P: 1-25
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Michael Seldin and colleagues report a genome-wide association study and meta-analyses for primary biliary cirrhosis. They identify three loci newly associated with susceptibility to this autoimmune liver disease.

Xiangdong Liu
Pietro Invernizzi
Michael F Seldin
Research18 Jul 2010
Nature Genetics

Volume: 42, P: 658-660
Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains

This study characterizes the properties of disease-causing mutations that produce sporadic amino acid replacements in proteins of people with autism and developmental delay. The mutations tend to cluster and reoccur at specific regions important to protein function, highlighting for future follow-up ∼200 candidate genes, many involved in neuronal signaling.

Madeleine R Geisheker
Gabriel Heymann
Evan E Eichler
Research19 Jun 2017
Nature Neuroscience

Volume: 20, P: 1043-1051
Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Detailed knowledge of the characteristics of COVID-19 patients helps with public health planning. Here, the authors use routinely-collected data from seven databases in three countries to describe the characteristics of >30,000 patients admitted with COVID-19 and compare them with those admitted for influenza in previous years.

Edward Burn
Seng Chan You
Patrick Ryan
ResearchOpen Access06 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Advanced systems and technologies for the enhancement of user experience in cultural spaces: an overview

Sonia Capece
Camelia Chivăran
Mario Buono
ResearchOpen Access28 Feb 2024
Heritage Science

Volume: 12, P: 1-25
Digital PCR for high sensitivity viral detection in false-negative SARS-CoV-2 patients

Paolo Poggio
Paola Songia
Maurizio Pesce
ResearchOpen Access22 Feb 2021
Scientific Reports

Volume: 11, P: 1-7
Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Keeping viral vaccines cold from the manufacturers to patients is problematic and costly. Here, Krol and others show additives that can significantly improve at very low concentrations the storage of adenovirus type 5 at ambient and elevated temperature.

Maria Pelliccia
Patrizia Andreozzi
Silke Krol
ResearchOpen Access30 Nov 2016
Nature Communications

Volume: 7, P: 1-7
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Self-assembled Bismuth Selenide (Bi₂Se₃) quantum dots grown by molecular beam epitaxy

Marcel S. Claro
Ido Levy
Maria C. Tamargo
ResearchOpen Access04 Mar 2019
Scientific Reports

Volume: 9, P: 1-7
Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy

Matteo Pacini
Alessandro Zucchi
Riccardo Bartoletti
ResearchOpen Access05 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27^Kip1 by PKB/Akt-mediated phosphorylation in breast cancer

Giuseppe Viglietto
Maria Letizia Motti
Massimo Santoro
Research16 Sept 2002
Nature Medicine

Volume: 8, P: 1136-1144
GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system

Alba Clara Fernández-Rilo
Emmanuel de Billy
Maria Vinci
ReviewsOpen Access21 Aug 2025
npj Precision Oncology

Volume: 9, P: 1-15
A polymer optoelectronic interface restores light sensitivity in blind rat retinas

The popular organic semiconductor P3HT, which is commonly used in polymer solar cells and photodetectors, is demonstrated to be able to act as a biocompatible optoelectronic interface for the retina of blind rats.

Diego Ghezzi
Maria Rosa Antognazza
Fabio Benfenati
Research17 Mar 2013
Nature Photonics

Volume: 7, P: 400-406
Novel deletion of the E3A ubiquitin protein ligase gene detected by multiplex ligation-dependent probe amplification in a patient with Angelman syndrome

Francesco Calì
Alda Ragalmuto
Maurizio Elia
ResearchOpen Access11 Nov 2010
Experimental & Molecular Medicine

Volume: 42, P: 842-848
Profiling Covid-19 patients with respect to level of severity: an integrated statistical approach

Federica Cugnata
Maria Giovanna Scarale
Chiara Lanzani
ResearchOpen Access04 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Exon deletions of the phenylalanine hydroxylase gene in Italian hyperphenylalaninemics

Francesco Calì
Giuseppa Ruggeri
Valentino Romano
ResearchOpen Access30 Nov 2009
Experimental & Molecular Medicine

Volume: 42, P: 81-86
The complex anatomy of the bronchial arteries: a meta-analysis with potential implications for thoracic surgery and hemoptysis treatment

Patryk Ostrowski
Michał Bonczar
Grzegorz Wysiadecki
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Genome-wide association meta-analyses among 1.4 million individuals identify 318 new risk loci for type 2 diabetes and provide insight into the contribution of these risk variants to diabetes-related vascular outcomes.

Marijana Vujkovic
Jacob M. Keaton
Danish Saleheen
Research15 Jun 2020
Nature Genetics

Volume: 52, P: 680-691
Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis

Francesca Ricciardiello
Giuseppina Votta
Ferdinando Chiaradonna
ResearchOpen Access07 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-17
Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs

Maurilio Sampaolesi
Stephane Blot
Giulio Cossu
Research01 Nov 2006
Nature

Volume: 444, P: 574-579
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during gene transcription.

Fernando Gómez-Herreros
Guido Zagnoli-Vieira
Keith W. Caldecott
ResearchOpen Access10 Aug 2017
Nature Communications

Volume: 8, P: 1-9
COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas

Maria Armentano
Shen-Ju Chou
Michèle Studer
Research09 Sept 2007
Nature Neuroscience

Volume: 10, P: 1277-1286
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response

BEHAV3D is a 3D live imaging platform for analyzing engineered T cell behavior and tumor response. This provides insights into the mode of action of cellular immunotherapy, capturing heterogeneity within and between tumors during treatment response.

Maria Alieva
Mario Barrera Román
Anne C. Rios
Protocols19 Mar 2024
Nature Protocols

Volume: 19, P: 2052-2084
PCSK9 induces a pro-inflammatory response in macrophages

Chiara Ricci
Massimiliano Ruscica
Nicola Ferri
ResearchOpen Access02 Feb 2018
Scientific Reports

Volume: 8, P: 1-10
Assessing the perioperative outcomes of abdominal drain omission after robot-assisted partial nephrectomy

Francesco Ditonno
Riccardo Bertolo
Alessandro Antonelli
ResearchOpen Access15 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Effectiveness of medical taping concept in primary dysmenorrhoea: a two-armed randomized trial

María Isabel Tomás-Rodríguez
Antonio Palazón-Bru
Vicente Francisco Gil-Guillén
ResearchOpen Access13 Nov 2015
Scientific Reports

Volume: 5, P: 1-9
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Chris Jones, Jacques Grill and colleagues report the identification of recurrent activating mutations in ACVR1 in diffuse intrinsic pontine gliomas.

Kathryn R Taylor
Alan Mackay
Jacques Grill
Research06 Apr 2014
Nature Genetics

Volume: 46, P: 457-461
Copper-surface-mediated synthesis of acetylenic carbon-rich nanofibers for active metal-free photocathodes

While photoelectrochemical devices combine light-absorption with fuel and electricity generation, their implementation is hampered by high costs and low output. Here, the authors synthesized acetylene-rich carbon fibers by copper-mediated polymerization for high-activity, metal-free photocathodes.

Tao Zhang
Yang Hou
Xinliang Feng
ResearchOpen Access19 Mar 2018
Nature Communications

Volume: 9, P: 1-11
The land and its people

Large tracts of agricultural land are being bought up by external investors. Turning the land into a commodity can have detrimental effects, for generations to come, on the local communities that sell or lease the land.

Paolo D'Odorico
Maria Cristina Rulli
Comments & Opinion29 Apr 2014
Nature Geoscience

Volume: 7, P: 324-325
AI prediction model for endovascular treatment of vertebrobasilar occlusion with atrial fibrillation

Zhi-Xin Huang
Andrea M. Alexandre
Wen Sun
ResearchOpen Access02 Feb 2025
npj Digital Medicine

Volume: 8, P: 1-9
Embodying the avatar of an omnipotent agent modulates the perception of one’s own abilities and enhances feelings of invulnerability

Althea Frisanco
Michael Schepisi
Salvatore Maria Aglioti
ResearchOpen Access14 Dec 2022
Scientific Reports

Volume: 12, P: 1-14
Spectroscopic characterization and assessment of microbiological potential of 1,3,4-thiadiazole derivative showing ESIPT dual fluorescence enhanced by aggregation effects

Iwona Budziak-Wieczorek
Lidia Ślusarczyk
Arkadiusz Matwijczuk
ResearchOpen Access22 Dec 2022
Scientific Reports

Volume: 12, P: 1-19
Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Simona Daniele
Chiara Giacomelli
Claudia Martini
ResearchOpen Access23 Oct 2015
Scientific Reports

Volume: 5, P: 1-17
A Reduction in the Amount and Anti-Contractile Effect of Periadventitial Mesenteric Adipose Tissue Precedes Hypertension Development in Spontaneously Hypertensive Rats

Beatriz Gálvez-Prieto
Galyna Dubrovska
Maria S Fernández-Alfonso
Research01 Jul 2008
Hypertension Research

Volume: 31, P: 1415-1423

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