Hydrogen deuterium exchange (HDE) methods hold promise as relevant tools for the late-stage and one-step preparation of deuterium-labelled compounds, but they often fall short in achieving sufficient isotopic purity combined either with a site-selectivity or with a full deuteration process. Here, the authors report an approach to unlock the potential of HDE using the concept of iterative runs in continuous-flow technology.
- Kevin Tatoueix
- Marco Lepron
- Sophie Feuillastre
