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Showing 1–2 of 2 results
Advanced filters: Author: Marine Aglave Clear advanced filters

  • The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the authors report that BRCA1/2 and ADAR1 are synthetic lethal, showing that ADAR1 depletion in BRCA1-mutant cells causes autocrine interferon poisoning

    • Roman M. Chabanon
    • Liudmila Shcherbakova
    • Sophie Postel-Vinay
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • To improve our understanding of the pathological role of TET2 mutations, Pronier, Imanci et al. use mice and human cells to show that TET2 downregulation promotes the production of macrophage migration inhibitory factor (MIF). In addition they show that whilst TET2 is recruited to the MIF promoter in healthy monocytes, decreased TET2 expression results in chronic overproduction of MIF - suggesting that MIF signaling could therefore constitute a potential therapeutic target for conditions associated with TET2 mutations.

    • Elodie Pronier
    • Aygun Imanci
    • Nathalie M. Droin
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15