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Pancreatic organogenesis mapped through space and time

Marissa A. Scavuzzo
Wojciech J. Szlachcic
Malgorzata Borowiak
ResearchOpen Access08 Jan 2025
Experimental & Molecular Medicine

Volume: 57, P: 204-220
Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely to become beta cells

Marissa A. Scavuzzo
Matthew C. Hill
Malgorzata Borowiak
ResearchOpen Access22 Aug 2018
Nature Communications

Volume: 9, P: 1-21
Pervasive environmental chemicals impair oligodendrocyte development

Oligodendrocytes are vulnerable to chemical toxicity during development. However, few environmental chemicals have been identified as potential hazards. Here, the authors discover chemicals in common household products as harmful to oligodendrocyte development.

Erin F. Cohn
Benjamin L. L. Clayton
Paul J. Tesar
Research25 Mar 2024
Nature Neuroscience

Volume: 27, P: 836-845
Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

In vitro differentiation of pancreatic beta cells offers a potential therapeutic approach for diabetes. Here they show human pluripotent stem cell derived pancreatic progenitors differentiate into insulin-secreting cells by crosstalk of WNT5A and BMP signaling.

Jolanta Chmielowiec
Wojciech J. Szlachcic
Malgorzata Borowiak
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-18
Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development

Alternative splicing is a process during gene expression that increases the diversity of proteins encoded by a single gene. Here, the authors perform RNA-sequencing on cardiac cells from mice and show that extensive changes in gene expression and alternative splicing occur during the first month after birth.

Jimena Giudice
Zheng Xia
Thomas A. Cooper
Research22 Apr 2014
Nature Communications

Volume: 5, P: 1-15
Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases

Diane Yang
Marissa A Scavuzzo
Malgorzata Borowiak
ResearchOpen Access18 Feb 2016
Scientific Reports

Volume: 6, P: 1-15
Implementation and validation of single-cell genomics experiments in neuroscience

Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance of their findings. Here the authors discuss options to support such findings and their challenges.

Marco Colonna
Genevieve Konopka
Naomi Habib
Reviews03 Dec 2024
Nature Neuroscience

Volume: 27, P: 2310-2325
Organotypic pancreatoids with native mesenchyme develop Insulin producing endocrine cells

Marissa A. Scavuzzo
Diane Yang
Malgorzata Borowiak
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-12

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