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Showing 101–150 of 8177 results
Advanced filters: Author: Mark A. Green Clear advanced filters
  • In this Review, Nicholas Chew and colleagues use epidemiological data on the cardiovascular–liver–metabolic disease syndemic to illustrate current and future projections on the burden of these diseases and their risk factors, and propose a unified framework for integrating and implementing effective multisystem interventions to tackle key components of this syndemic.

    • Nicholas W. S. Chew
    • Anurag Mehta
    • Laurence S. Sperling
    Reviews
    Nature Reviews Cardiology
    P: 1-20
  • Distal gene regulation is increasingly recognised as a major contributor to complex trait variability. Here, the authors show that a heritable, biologically interpretable transcriptome signature driven by distal regulation predicts metabolic traits across mice and humans.

    • Anna L. Tyler
    • J. Matthew Mahoney
    • Gregory W. Carter
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21
  • Despite exhibiting ferroelectric features, SrTiO3 fails to display long-range polar order at low temperatures due to quantum fluctuations. An ultrafast X-ray diffraction experiment now probes polar dynamics of this material at the nanometre scale.

    • Gal Orenstein
    • Viktor Krapivin
    • Mariano Trigo
    Research
    Nature Physics
    Volume: 21, P: 961-965
  • The Nr4a family of nuclear receptors has been implicated in thymocyte central tolerance via clonal deletion and regulatory T cell induction. Here the authors show, using mouse bone marrow chimeras, that Nr4a1 and Nr4a3 are also redundantly required for Bcl211/BIM induction and contribute to an anergy-like transcriptome in auto-reactive thymocytes.

    • Hailyn V. Nielsen
    • Letitia Yang
    • Julie Zikherman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22
  • While learning a typing task, epilepsy patients show higher hippocampal ripple rates during brief rest breaks than while typing. These ‘offline’ ripples predict gains in speed, suggesting that ripples contribute to motor learning during wakeful rest.

    • Martin Sjøgård
    • Bryan Baxter
    • Dara S. Manoach
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Grain boundaries strongly influence the properties of crystalline materials, but identifying their multiple phases remains difficult. Here, authors show a new tool for automated grain boundary structure prediction with an application to Ti.

    • Enze Chen
    • Tae Wook Heo
    • Timofey Frolov
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10
  • Vagus nerve stimulation (VNS) is emerging as a potential treatment for several chronic diseases. Here, the authors describe a VNS method using intermittent interferential current stimulation (i2CS) that allows precise control of organ-specific fiber activation in swine.

    • Nicolò Rossetti
    • Weiguo Song
    • Stavros Zanos
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330
  • The human brain cycles through a repertoire of brain networks on a 1-second timescale during rest and tasks. This cycling appears to allow periodic engagement of essential cognitive functions, with the speed of cycling linked to genetics and age.

    • Mats W. J. van Es
    • Cameron Higgins
    • Mark W. Woolrich
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 2118-2128
  • PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.

    • Gilles Rademaker
    • Grace A. Hernandez
    • Rushika M. Perera
    Research
    Nature
    Volume: 643, P: 1381-1390
  • Shabanzadeh et al. identify and validate a pathway whereby RGMa cleavage by SKI-1 modifies gene expression related to blood–brain barrier (BBB) integrity after stroke. SKI-1 inhibition restores BBB integrity and neuronal function in mouse and rabbit stroke models.

    • Alireza P. Shabanzadeh
    • Dene Ringuette
    • Philippe P. Monnier
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1094-1113
  • Machine-learning algorithms trained on 25,000 geolocated soil samples are used to create high-resolution global maps of mycorrhizal fungi, revealing that less than 10% of their biodiversity hotspots are in protected areas.

    • Michael E. Van Nuland
    • Colin Averill
    • Johan van den Hoogen
    ResearchOpen Access
    Nature
    Volume: 645, P: 414-422
  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21
  • Lymphostatin is a large protein required for Escherichia coli virulence. Here, Griessmann et al. use electron cryo-microscopy to describe the structure of lymphostatin determined at different pH values, showing three conformations, six distinct domains, and long inter-domain linkers that occlude the catalytic sites of the N-terminal glycosyltransferase and protease domains.

    • Matthias Griessmann
    • Tim Rasmussen
    • Bettina Böttcher
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Sex differences are well established in the prevalence and symptoms of depression. Here, the authors identify a novel X chromosome variant, greater genetic risk, and stronger links to metabolic traits in females, highlighting the importance of sex-aware approaches.

    • Jodi T. Thomas
    • Jackson G. Thorp
    • Brittany L. Mitchell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Introducing organic guests to a crystal is a convenient way to tailor its properties. Here, the authors occlude fluorescent dyes within calcite to reveal that additives can occupy distinct zones of a crystal, and strategically embed green, blue, and red dyes to create white fluorescent calcite.

    • David C. Green
    • Johannes Ihli
    • Fiona C. Meldrum
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13
  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • Here, the authors show that delafloxacin, a respiratory antibacterial fluoroquinolone, binds the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex in a distinct tilted-ring conformation involving multiple Mg2 + , K+ and water links. Intrinsic target affinity likely contributes to activity against quinolone-resistant bacteria.

    • Shabir Najmudin
    • Xiao-Su Pan
    • Mark R. Sanderson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

    • Marc Zapatka
    • Ivan Borozan
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 320-330
    • Yingnian Tao
    • Mark Ryan
    ResearchOpen Access
    Humanities and Social Sciences Communications
    Volume: 12, P: 1-15
  • Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.

    • Atanas G. Atanasov
    • Sergey B. Zotchev
    • Claudiu T. Supuran
    Reviews
    Nature Reviews Drug Discovery
    Volume: 20, P: 200-216
  • In this work, through a comprehensive proteomics approach, the authors identified host plasma protein biosignatures that could distinguish tuberculosis (TB) disease in children.

    • Andrea Fossati
    • Peter Wambi
    • Danielle L. Swaney
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Retromer complex cooperates with Vps5 and Vps17 in yeast to traffic transmembrane proteins. Here, the authors present structural and functional studies that reveal the mechanism of Retromer and Vps5 interaction.

    • Kai-En Chen
    • Vikas A. Tillu
    • Brett M. Collins
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • A free-living trial in people with overweight or obesity found that minimally processed diets led to greater weight loss and cardiometabolic improvements than ultraprocessed diets following UK healthy eating guidelines at 8 weeks.

    • Samuel J. Dicken
    • Friedrich C. Jassil
    • Rachel L. Batterham
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 3297-3308
  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710
  • Candida albicans normally relies on specific pathogenicity mechanisms to cause tissue damage. This study reveals that when sensing host albumin, C. albicans, even avirulent strains, can trigger an alternative pathogenicity pathway via transcriptional and metabolic reprogramming.

    • Sophia U. J. Hitzler
    • Candela Fernández-Fernández
    • Mark S. Gresnigt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477