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Showing 351–400 of 900 results
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  • Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

    • Lianglong Sun
    • Tengda Zhao
    • Yong He
    Research
    Nature Neuroscience
    Volume: 28, P: 891-901
  • The integration of barium titanate thin films with silicon-based waveguides enables the operation of efficient electro-optic switches and modulators at temperatures as low as 4 K, with potential applications in quantum computing and cryogenic computing technologies.

    • Felix Eltes
    • Gerardo E. Villarreal-Garcia
    • Stefan Abel
    Research
    Nature Materials
    Volume: 19, P: 1164-1168
  • C4 photosynthesis is thought to be more efficient than the ancestral C3 form, but data directly comparing the two are inconsistent. This study compares 382 grasses and finds a consistent increase in growth and greater investment in water and nutrient acquisition in C4 species.

    • Rebecca R. L. Atkinson
    • Emily J. Mockford
    • Colin P. Osborne
    Research
    Nature Plants
    Volume: 2, P: 1-5
  • Little is known about the genetic landscape of people living in the Nile region prior to the Islamic migrations of the late 1st millennium CE. Here, the authors report genome-wide data for 66 ancient individuals to investigate the genetic ancestry of a Christian Period group from Kulubnarti.

    • Kendra A. Sirak
    • Daniel M. Fernandes
    • David Reich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • In plants, plasma membrane topologies are predominantly driven by the cell wall. In this study, the authors demonstrate that remorin proteins can take over these functions at specialized, unwalled plasma membranes such as infection droplets associated with symbiotic infection threads.

    • Chao Su
    • Marta Rodriguez-Franco
    • Thomas Ott
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • Worldwide, 170 million people are infected with the hepatitis C virus, which is a significant cause of liver-related illnesses and deaths. Standard treatment combines pegylated interferon alpha and ribavirin (RBV), but has some negative effects, notably RBV-induced haemolytic anaemia. Here, a genome-wide study shows that a deficiency in the enzyme inosine triphosphatase protects against haemolytic anaemia in patients receiving RBV.

    • Jacques Fellay
    • Alexander J. Thompson
    • David B. Goldstein
    Research
    Nature
    Volume: 464, P: 405-408
  • Ascaroside pheromones reflect population density in Caenorhabditis elegans. Here, the authors show that variation in ascaroside receptor genes contributes to differences in pheromone responses in natural populations of C. elegans.

    • Daehan Lee
    • Stefan Zdraljevic
    • Erik C. Andersen
    Research
    Nature Ecology & Evolution
    Volume: 3, P: 1455-1463
  • The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response when comparing to MTAP-proficient UC patients.

    • Omar Alhalabi
    • Jianfeng Chen
    • Jianjun Gao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • The identification of prognostic biomarkers can help stratify cancer patients. Here, the authors apply deep RNA sequencing from primary melanomas coupled with long-term clinical outcome data from a prospective multicentre phase III trial, to develop and validate a 121 metastasis-associated gene signature identifying early-stage melanoma patients at higher risk of metastasis and worse survival.

    • Manik Garg
    • Dominique-Laurent Couturier
    • Roy Rabbie
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • Somatic mutations have been reported in pancreatic adenocarcinomas. Here, Sausen et al. identify further mutations and find that mutations in the chromatin modifying gene, MLL, are associated with increased survival, and that the presence of circulating tumour DNA in the serum of patients is associated with poor survival.

    • Mark Sausen
    • Jillian Phallen
    • Victor E. Velculescu
    Research
    Nature Communications
    Volume: 6, P: 1-6
  • Changes to structural and functional connectivity can give rise to neurodegeneration and neurodevelopmental diseases. Here the authors investigate molecular and connectomic patterns in 13 different neurological, psychiatric and neurodevelopmental diseases from the ENIGMA consortium.

    • Justine Y. Hansen
    • Golia Shafiei
    • Bratislav Misic
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17
  • Using a season-long field manipulation with an established model fish system on the Great Barrier Reef, this study demonstrates that limiting motorboat activity on reefs leads to faster growth and survival of more fish offspring compared to reefs experiencing busy motorboat traffic. Noise mitigation and abatement could therefore present a valuable opportunity for enhancing ecosystem resilience.

    • Sophie L. Nedelec
    • Andrew N. Radford
    • Stephen D. Simpson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9
  • Inter-organismal signaling is essential for animals to navigate and survive in their natural environment, yet is unclear how these chemical communication channels may have evolved. Here, authors show that TYRA-2, an endogenous tyramine/octopamine receptor, is required for the chemosensation of an octopamine-derived pheromone and that this signaling system represents an inter-organismal communication channel that evolved via co-option of a neurotransmitter and its cognate receptor

    • Christopher D. Chute
    • Elizabeth M. DiLoreto
    • Jagan Srinivasan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13
  • The volume of subcortical brain structures is known to be heritable. Here, Roshchupkin and colleagues studied seven different subcortical brain structures in the general population and show that the genetic contributions go beyond these volumetric measurements, and also extend to their shapes.

    • Gennady V. Roshchupkin
    • Boris A. Gutman
    • Hieab H. H. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8
  • A fully programmable two-qubit quantum processor with more than 200 components is demonstrated by using silicon photonic circuits. A two-qubit quantum approximate optimization algorithm and simulation of Szegedy quantum walks are implemented.

    • Xiaogang Qiang
    • Xiaoqi Zhou
    • Jonathan C. F. Matthews
    Research
    Nature Photonics
    Volume: 12, P: 534-539
  • Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

    • Xueyi Shen
    • David M. Howard
    • Andrew M. McIntosh
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • By examining the hourly diurnal cycle of 23,557 fires in North America during 2017–2020, 1,095 overnight burning events were identified, mostly associated with extreme fires and driven by long-term drought conditions.

    • Kaiwei Luo
    • Xianli Wang
    • Mike Flannigan
    Research
    Nature
    Volume: 627, P: 321-327
  • Entangled photon states can be used to make quantum information more robust. A photonic experimental implementation with eight qubits shows that error-protection schemes can increase the success rate of running a quantum algorithm.

    • Caterina Vigliar
    • Stefano Paesani
    • Anthony Laing
    Research
    Nature Physics
    Volume: 17, P: 1137-1143
  • A multivariate genome-wide association study highlighting loci that influence both face and brain shape suggesting shared developmental axes during early embryogenesis. These loci did not overlap with those governing behavioral–cognitive traits or neuropsychiatric risk indicating divergence between early brain development and cognitive function.

    • Sahin Naqvi
    • Yoeri Sleyp
    • Peter Claes
    Research
    Nature Genetics
    Volume: 53, P: 830-839
  • The genomic profiling of tumours has not been widely adopted in the clinic due to technical and practical hurdles. Here, the authors develop PGDx elio tissue complete, a scalable, standardised and FDA-cleared test comprising a targeted gene panel and automated machine-learning analysis, which detects clinically relevant sequence biomarkers in cancer samples.

    • Laurel A. Keefer
    • James R. White
    • Mark Sausen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • Amanda Spurdle, Ian Tomlinson, Douglas Easton and colleagues conduct a GWAS meta-analysis and identify five new risk loci for endometrial cancer. Functional studies show that one risk-associated SNP is located in an active chromatin region that interacts with the KLF5 promoter.

    • Timothy H T Cheng
    • Deborah J Thompson
    • Amanda B Spurdle
    Research
    Nature Genetics
    Volume: 48, P: 667-674
  • Sequencing and de novo assembly of the maize W22 reference genome enable accurate placement of Mutator (Mu) and Dissociation (Ds) transposable element insertions, providing a foundation for maize functional genomics and transposon biology.

    • Nathan M. Springer
    • Sarah N. Anderson
    • Thomas P. Brutnell
    ResearchOpen Access
    Nature Genetics
    Volume: 50, P: 1282-1288
  • Stellar data from the Kepler spacecraft are used to infer the existence of a sub-Mercury-sized exoplanet, the smallest yet discovered, in orbit around a Sun-like star.

    • Thomas Barclay
    • Jason F. Rowe
    • Susan E. Thompson
    Research
    Nature
    Volume: 494, P: 452-454
  • In Alzheimer’s disease (AD) tau and neurodegeneration have complex regional relationships. Here, the authors show neuronal hypometabolism discordant with tau burden defines functional resilience or susceptibility to Alzheimer’s pathology via limbic/cortical axes. Susceptible groups have faster cognitive decline and evidence of non-Alzheimer’s pathologies.

    • Michael Tran Duong
    • Sandhitsu R. Das
    • Ilya M. Nasrallah
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • The interplay between amyloid and tau pathology in Alzheimer’s disease is still not well understood. Here, the authors show that amyloid-related increased in soluble p-tau is related to subsequent accumulation of tau aggregates and cognitive decline in early stage of the disease.

    • Alexa Pichet Binette
    • Nicolai Franzmeier
    • Oskar Hansson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16
  • Uniform processing and detailed annotation of human, worm and fly RNA-sequencing data reveal ancient, conserved features of the transcriptome, shared co-expression modules (many enriched in developmental genes), matched expression patterns across development and similar extent of non-canonical, non-coding transcription; furthermore, the data are used to create a single, universal model to predict gene-expression levels for all three organisms from chromatin features at the promoter.

    • Mark B. Gerstein
    • Joel Rozowsky
    • Robert Waterston
    ResearchOpen Access
    Nature
    Volume: 512, P: 445-448
  • Tarpey et al. carry out a large-scale systematic sequencing of the majority of X-chromosome coding exons from 208 families with multiple individuals with mental retardation and a pattern of transmission compatible with X linkage in order to identify XLMR-causative mutations. They find several mutations that appear to be causative in loci already known to be involved in XLMR, as well as new data about those loci, and make inferences about the role of the different classes of variants in these diseases.

    • Patrick S Tarpey
    • Raffaella Smith
    • Michael R Stratton
    Research
    Nature Genetics
    Volume: 41, P: 535-543
  • Previous studies have linked over 100 genomic loci to age-at-menarche but that work was restricted to common autosomal variation. Here, Lunetta et al. identify associations with rare protein-coding and X-linked variants, implicating new mechanisms that regulate puberty timing.

    • Kathryn L. Lunetta
    • Felix R. Day
    • John R. B. Perry
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8
  • Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can give the impression of paternal mtDNA transmission, but are actually inherited through the nuclear genome.

    • Wei Wei
    • Alistair T. Pagnamenta
    • Patrick F. Chinnery
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11
  • This paper explores legal processes for penalty setting in water theft cases in transboundary water systems and develops ideas to identify differences and potentially drive consistency between jurisdictions.

    • Adam Loch
    • Michael Croft
    • Mark Giancaspro
    Research
    Nature Water
    Volume: 2, P: 380-389
  • Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are commonly found in glioblastomas, a major subset of primary human brain cancers. However, only a single copy of the gene is mutated, suggesting that the mutation does not result in a simple loss of function. Here, IDH1 mutations are shown to act in a gain-of-function manner, resulting in a new ability of the enzyme to catalyse α-ketoglutarate to R(-)-2-hydroxyglutarate, an onco-metabolite.

    • Lenny Dang
    • David W. White
    • Shinsan M. Su
    Research
    Nature
    Volume: 462, P: 739-744
  • Experiments report the generation and manipulation of eight photons on a silicon chip. Integrating linear and nonlinear photonic circuitry, three different boson sampling approaches are implemented and used to compute molecular vibronic spectra.

    • Stefano Paesani
    • Yunhong Ding
    • Anthony Laing
    Research
    Nature Physics
    Volume: 15, P: 925-929
  • Analyses of the relationships between temperature, moisture and seven key plant functional traits across the tundra and over time show that community height increased with warming across all sites, whereas other traits lagged behind predicted rates of change.

    • Anne D. Bjorkman
    • Isla H. Myers-Smith
    • Evan Weiher
    Research
    Nature
    Volume: 562, P: 57-62
  • Copy number variants (CNVs) account for a major proportion of human genetic diversity and may contribute to genetic susceptibility to disease. Here, a large, genome-wide study of association between common CNVs and eight common human diseases is presented. The study provides a wealth of technical insights that will inform future study design and analysis. The results also indicate that common CNVs that can be 'typed' on existing platforms are unlikely to contribute much to the genetic basis of common diseases.

    • Nick Craddock
    • Matthew E. Hurles
    • Peter Donnelly
    Research
    Nature
    Volume: 464, P: 713-720