Thrombolysis was first shown to be effective for treating acute ischemic stroke around 15 years ago, but therapeutic uptake worldwide has been modest to date. Here, Donnan et al. outline the various strategies that are being explored to optimize the use of thrombolysis, including enhancement of thrombolytic efficacy, extension of the therapeutic time window, reduction in the risk of intracerebral hemorrhage, and improvements in prehospital and in-hospital patient management.
- Geoffrey A. Donnan
- Stephen M. Davis
- David W. Howells
