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Showing 1–3 of 3 results
Advanced filters: Author: Mark Philip Plummer Clear advanced filters

  • Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis.

    • Mark Philip Plummer
    • Rinaldo Bellomo
    News & Views
    Nature Reviews Nephrology
    Volume: 18, P: 607-608

  • A robust, cost-effective technique based on whole-exome sequencing data can be used to characterize immune infiltrates, relate the extent of these infiltrates to somatic changes in tumours, and enables prediction of tumour responses to immune checkpoint inhibition therapy.

    • Robert Bentham
    • Kevin Litchfield
    • Nicholas McGranahan
    Research
    Nature
    Volume: 597, P: 555-560