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Showing 451–500 of 579 results

Advanced filters: Author: Mark W Robinson Clear advanced filters

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
diffcyt: Differential discovery in high-dimensional cytometry via high-resolution clustering

Lukas Weber et al. present diffcyt, an open-source computational framework for differential analysis of high-dimensional flow and mass cytometry data. The diffcyt framework uses high-resolution clustering and empirical Bayes moderated tests to provide improved statistical performance, flexible experimental designs, and fast runtimes.

Lukas M. Weber
Malgorzata Nowicka
Mark D. Robinson
ResearchOpen Access14 May 2019
Communications Biology

Volume: 2, P: 1-11
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
Remotely sensed above-ground storage tank dataset for object detection and infrastructure assessment

Celine Robinson
Kyle Bradbury
Mark E. Borsuk
ResearchOpen Access12 Jan 2024
Scientific Data

Volume: 11, P: 1-9
The UK General Practice Airways Group (GPIAG): its formation, development, and influence on the management of asthma and other respiratory diseases over the last twenty years

Mark L Levy
Paul Stephenson
Anne Smith
Reviews27 May 2007
Primary Care Respiratory Journal

Volume: 16, P: 132-139
Count-based differential expression analysis of RNA sequencing data using R and Bioconductor

Simon Anders
Davis J McCarthy
Mark D Robinson
Protocols22 Aug 2013
Nature Protocols

Volume: 8, P: 1765-1786
Autoantigen microarrays for multiplex characterization of autoantibody responses

William H. Robinson
Carla DiGennaro
Paul J. Utz
Advertorial01 Mar 2002
Nature Medicine

Volume: 8, P: 295-301
Precision subclassification of type 2 diabetes: a systematic review

Misra, Wagner et al. systematically review if strategies to subclassify type 2 diabetes (T2D) are associated with high quality evidence and patient outcomes. Cluster-based stratification yields T2D subtypes that associate with outcomes, suggesting subclassification could have future clinical use.

Shivani Misra
Robert Wagner
Miriam S. Udler
ResearchOpen Access05 Oct 2023
Communications Medicine

Volume: 3, P: 1-19
Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells

Jan. P. Gerlach
Jessie A. G. van Buggenum
Klaas W. Mulder
ResearchOpen Access06 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

Joshua R. Brickner
Jennifer M. Soll
Nima Mosammaparast
Research08 Nov 2017
Nature

Volume: 551, P: 389-393
Synthetic recording and in situ readout of lineage information in single cells

A new system, termed MEMOIR, allows cells to record lineage and gene expression history within their own genome in a format that can be read out in single cells in situ.

Kirsten L. Frieda
James M. Linton
Long Cai
Research21 Nov 2016
Nature

Volume: 541, P: 107-111
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers

Boris B Quednow
Michael Kometer
Franz X Vollenweider
Research28 Sept 2011
Neuropsychopharmacology

Volume: 37, P: 630-640
Investigation of type I interferon responses in ANCA-associated vasculitis

Isabella Batten
Mark W. Robinson
Nollaig M. Bourke
ResearchOpen Access15 Apr 2021
Scientific Reports

Volume: 11, P: 1-11
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching

Evgenii Belykh
Eric J. Miller
Mark C. Preul
ResearchOpen Access22 Aug 2018
Scientific Reports

Volume: 8, P: 1-14
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

Ketan Patel and colleagues report a new mouse model of Fanconi anemia. The authors show that mice deficient in Btbd12, the mouse ortholog of SLX4 (a new Fanconi anemia gene), phenocopy the human disease.

Gerry P Crossan
Louise van der Weyden
Ketan J Patel
Research16 Jan 2011
Nature Genetics

Volume: 43, P: 147-152
Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers

The risk of germline copy number variants (CNVs) in BRCA1 and BRCA2 pathogenic variant carriers in breast cancer is assessed, with CNVs overlapping SULT1A1 decreasing breast cancer risk in BRCA1 carriers.

Christopher Hakkaart
John F. Pearson
Logan C. Walker
ResearchOpen Access06 Oct 2022
Communications Biology

Volume: 5, P: 1-15
Aeciospore ejection in the rust pathogen Puccinia graminis is driven by moisture ingress

Bueno-Sancho et al. use high-speed videography and mathematical modelling to examine aeciospore dispersal mechanics of the stem rust fungus Puccinia graminis. Their model shows that aeciospore ejection is driven by peridium rupture and moisture ingress, with dispersal projections encapsulated in a web interface to help assess risk of disease spread to nearby cereal crops.

Vanessa Bueno-Sancho
Elizabeth S. Orton
Diane G. O. Saunders
ResearchOpen Access22 Oct 2021
Communications Biology

Volume: 4, P: 1-10
Author Correction: Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

Alicia B. Byrne
Peer Arts
Hamish S. Scott
Amendments and Corrections10 Jul 2023
Nature Medicine

Volume: 30, P: 302
Author Correction: Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Tianyun Wang
Kendra Hoekzema
Evan E. Eichler
Amendments and CorrectionsOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1
A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms

Hannier Pulido
Nina M. Stanczyk
Mark C. Mescher
ResearchOpen Access06 Jul 2021
Scientific Reports

Volume: 11, P: 1-9
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions

Khalid AbdulJabbar
Shan E. Ahmed Raza
Yinyin Yuan
Research27 May 2020
Nature Medicine

Volume: 26, P: 1054-1062
TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

Janin Knop
Lisanne M. Spilgies
W. Wei-Lynn Wong
ResearchOpen Access20 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-14
Synthesis of the Pitstop family of clathrin inhibitors

Clathrin is a protein complex that has roles in endocytosis and mitosis. This Protocol describes the synthesis of the Pitstop family of clathrin inhibitors and their inactive controls.

Mark J Robertson
Fiona M Deane
Adam McCluskey
Protocols12 Jun 2014
Nature Protocols

Volume: 9, P: 1592-1606
BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

Qiang Wang
Hongtao Zhang
Mark I Greene
Research14 Oct 1998
Oncogene

Volume: 17, P: 1939-1948
`Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

Árpád Lányi
Debabrita Deb
Sumitra Deb
Research17 Jun 1998
Oncogene

Volume: 16, P: 3169-3176
Precision treatment of beta-cell monogenic diabetes: a systematic review

Naylor et al. systematically review the efficacy of treatments for beta-cell monogenic diabetes. Limited evidence from the mostly non-randomized, small studies supports no treatment in glucokinase-related hyperglycemia and sulfonylureas for HNF1A-diabetes; further evidence is needed on the optimum treatments in these and other monogenic subtypes.

Rochelle N. Naylor
Kashyap A. Patel
Tiinamaija Tuomi
ResearchOpen Access18 Jul 2024
Communications Medicine

Volume: 4, P: 1-17
Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis

Ahmad, Lim, Morieri, Tam et al perform a systematic review and meta-analysis of biomarkers, genetic markers, and risk scores for prediction of cardiovascular outcomes in Type 2 diabetes. A few prognostic markers are identified that provide incremental predictive utility beyond established cardiovascular risk factors.

Abrar Ahmad
Lee-Ling Lim
Nestoras Mathioudakis
ResearchOpen Access22 Jan 2024
Communications Medicine

Volume: 4, P: 1-28
Janus-faced EPHB4-associated disorders: novel pathogenic variants and unreported intrafamilial overlapping phenotypes

Silvia Martin-Almedina
Kazim Ogmen
Pia Ostergaard
ResearchOpen Access16 Apr 2021
Genetics in Medicine

Volume: 23, P: 1315-1324
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
The case for biotech on Mars

The stepwise application of biotechnology will be instrumental to addressing four key challenges of Martian settlement.

Shannon N. Nangle
Mikhail Y. Wolfson
Marika Ziesack
Comments & Opinion01 Apr 2020
Nature Biotechnology

Volume: 38, P: 401-407
Reduced Cyclic AMP Production in Fragile X Syndrome: Cytogenetic and Molecular Correlations

Elizabeth Berry-Kravis
Mark Hicar
Rita Ciurlionis
Research01 Nov 1995
Pediatric Research

Volume: 38, P: 638-643
Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
Climate change and cultural resilience in late pre-Columbian Amazonia

Across pre-Columbian Amazonia, the relationship between cultural transitions and climatic trends is assessed.

Jonas Gregorio de Souza
Mark Robinson
José Iriarte
Reviews17 Jun 2019
Nature Ecology & Evolution

Volume: 3, P: 1007-1017
In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study

Jie Luo
Esra Abaci Turk
Patricia Ellen Grant
ResearchOpen Access16 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Estrogen Promotes Mandibular Condylar Fibrocartilage Chondrogenesis and Inhibits Degeneration via Estrogen Receptor Alpha in Female Mice

Jennifer L. Robinson
Paola Soria
Sunil Wadhwa
ResearchOpen Access04 Jun 2018
Scientific Reports

Volume: 8, P: 1-13
Discrete taxa of saprotrophic fungi respire different ages of carbon from Antarctic soils

Kevin K. Newsham
Mark H. Garnett
Filipa Cox
ResearchOpen Access18 May 2018
Scientific Reports

Volume: 8, P: 1-10
Cage aggression in group-housed laboratory male mice: an international data crowdsourcing project

Katie Lidster
Kathryn Owen
Mark J. Prescott
ResearchOpen Access23 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
Unanswered questions in prostate cancer — findings of an international multi-stakeholder consensus by the PIONEER consortium

In this Consensus Statement, the authors present results from an international multi-stakeholder consensus conducted by the PIONEER consortium to identify the most important questions in the field of prostate cancer that could be addressed using big data.

Muhammad Imran Omar
Steven MacLennan
Daniel Kotik
Reviews03 Apr 2023
Nature Reviews Urology

Volume: 20, P: 494-501
Exploring the prognostic significance of arm-level copy number alterations in triple-negative breast cancer

Samuel Doré
Mariam Ali
Logan A. Walsh
ResearchOpen Access14 May 2024
Oncogene

Volume: 43, P: 2015-2024
Delineating COVID-19 subgroups using routine clinical data identifies distinct in-hospital outcomes

Bojidar Rangelov
Alexandra Young
Mark Radon
ResearchOpen Access20 Jun 2023
Scientific Reports

Volume: 13, P: 1-14
Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression

Theodore D Satterthwaite
Joseph W Kable
Daniel H Wolf
Research13 Mar 2015
Neuropsychopharmacology

Volume: 40, P: 2258-2268
Safety Assessment of the Neomycin Phosphotransferase II (NPTII) Protein

Roy L. Fuchs
Joel E. Ream
Sharon A. Berberich
Reviews01 Dec 1993
Bio/Technology

Volume: 11, P: 1543-1547
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

Pablo Carbonell et al. present an automated pipeline for the discovery and optimization of biosynthetic pathways for microbial production of fine chemicals. They apply their pipeline to the production of the flavonoid (2S)-pinocembrin in Escherichia coli and show improvement of the pathway by 500-fold.

Pablo Carbonell
Adrian J. Jervis
Nigel S. Scrutton
ResearchOpen Access08 Jun 2018
Communications Biology

Volume: 1, P: 1-10
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes

Angela Meccariello
Simona Maria Monti
Giuseppe Saccone
ResearchOpen Access30 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
Double-flow focused liquid injector for efficient serial femtosecond crystallography

Dominik Oberthuer
Juraj Knoška
Saša Bajt
ResearchOpen Access16 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase

Mark J Robertson
Fiona M Deane
Adam McCluskey
Protocols20 Mar 2014
Nature Protocols

Volume: 9, P: 851-870
Breeding crops to feed 10 billion

Development of next-generation crops will be enabled by combining state-of-the-art technologies with speed breeding.

Lee T. Hickey
Amber N. Hafeez
Brande B. H. Wulff
Reviews17 Jun 2019
Nature Biotechnology

Volume: 37, P: 744-754

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