Skeletal muscle has the capacity to produce, express and release several hundred secreted peptides, so-called myokines. This finding provides a conceptual basis and a new paradigm for understanding the role of skeletal muscle in organ crosstalk, including muscle–liver and muscle–adipose tissue crosstalk. This Review highlights the clinical role of myokines in mediating the multiple health benefits of exercise.
- Bente K. Pedersen
- Mark A. Febbraio
