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Showing 1–14 of 14 results

Advanced filters: Author: Marko Sarstedt Clear advanced filters

Tumour-specific STING agonist synthesis via a two-component prodrug system

STING is a promising drug target, but selective activation is necessary for safety and efficacy. Researchers have developed a two-component prodrug system for potent pharmacological activation of STING that offers excellent tumour targeting.

Nai-Shu Hsu
Cong Tang
Gonçalo J. L. Bernardes
ResearchOpen Access16 Sept 2025
Nature Chemistry

Volume: 17, P: 1941-1951
Reflection confocal microscopy for quantitative assessment of airway surface layer dysregulation and pharmacological rescue in cystic fibrosis under near-physiological conditions

Ayça Seyhan Agircan
Marko Lampe
Julia Duerr
ResearchOpen Access11 Dec 2025
Scientific Reports

Volume: 15, P: 1-14
Fabrication of cell culture hydrogels by robotic liquid handling automation for high-throughput drug testing

Eloisa Torchia and colleagues present HYDRA, a robotic approach for fabricating uniform and planar hydrogel layers in multiwell plates. The method enables scalable, imaging-compatible drug screening on physiologically relevant substrates

Eloisa Torchia
Moises Di Sante
Francesco Silvio Pasqualini
ResearchOpen Access22 Dec 2025
Communications Engineering

Volume: 4, P: 1-14
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation

Oxybipins were identified as potent selective inhibitors of oxysterol-binding protein, promoting Golgi fragmentation, inhibiting retrograde trafficking and attenuating Shiga toxin toxicity.

Nianzhe He
Laura Depta
Luca Laraia
Research21 Jun 2024
Nature Chemical Biology

Volume: 21, P: 203-214
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

The serotonin transporter, targeted by several medications, terminates neurotransmission by clearing serotonin from the synaptic cleft. Combining biochemical results with in silico data, the authors show the key interactions that initiate substrate transport.

Ralph Gradisch
Katharina Schlögl
Thomas Stockner
ResearchOpen Access10 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Virus-free transfection, transient expression, and purification of human cardiac myosin in mammalian muscle cells for biochemical and biophysical assays

Lok Priya Velayuthan
Luisa Moretto
Alf Månsson
ResearchOpen Access12 Mar 2023
Scientific Reports

Volume: 13, P: 1-15
Salt-responsive gut commensal modulates T_H17 axis and disease

High salt intake changed the gut microbiome and increased T_H17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of T_H17 cells and increased blood pressure in humans.

Nicola Wilck
Mariana G. Matus
Dominik N. Müller
Research15 Nov 2017
Nature

Volume: 551, P: 585-589
High-resolution membrane capacitance measurements for the study of exocytosis and endocytosis

Boštjan Rituper
Alenka Guček
Robert Zorec
Protocols23 May 2013
Nature Protocols

Volume: 8, P: 1169-1183
A sensitive recombinant cell-based bioluminescent assay for detection of androgen-like compounds

Elisa Michelini
Luca Cevenini
Aldo Roda
Protocols20 Nov 2008
Nature Protocols

Volume: 3, P: 1895-1902
Quantify uncertainty in behavioral research

The behavioral sciences underestimate the uncertainty of research findings and thus overestimate replicability. Metrologists in the physical sciences quantify all material components of uncertainty, even if some components must be quantified using non-statistical means. Behavioral science should follow suit.

Edward E. Rigdon
Marko Sarstedt
Jan-Michael Becker
Comments & Opinion08 Jan 2020
Nature Human Behaviour

Volume: 4, P: 329-331
Design, assembly, characterization, and operation of double-stranded interlocked DNA nanostructures

This protocol describes the detailed procedures for design, assembly, and characterization of different types of double-stranded DNA nanostructures, as well as a number of downstream applications.

Julián Valero
Mathias Centola
Michael Famulok
Protocols11 Sept 2019
Nature Protocols

Volume: 14, P: 2818-2855
Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation

Giorgia Del Favero
Lydia Woelflingseder
Doris Marko
ResearchOpen Access27 Jul 2018
Scientific Reports

Volume: 8, P: 1-17
Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling

Rami M. El Zein
Audrey H. Soria
Sheerazed Boulkroun
ResearchOpen Access11 Oct 2019
Scientific Reports

Volume: 9, P: 1-20
Identification of a novel human deoxynivalenol metabolite enhancing proliferation of intestinal and urinary bladder cells

Benedikt Warth
Giorgia Del Favero
Doris Marko
ResearchOpen Access23 Sept 2016
Scientific Reports

Volume: 6, P: 1-10