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Showing 1–50 of 110 results
Advanced filters: Author: Martin Krzywinski Clear advanced filters

  • Creators of software widely used in computational biology discuss the factors that contributed to their success

    • Stephen Altschul
    • Barry Demchak
    • Cole Trapnell
    Special Features
    Nature Biotechnology
    Volume: 31, P: 894-897

  • Efforts to allow routine whole genome and transcriptome analysis (WGTA) for pediatric cancers in the clinic remain critical. Here, the authors present results of a unified genomics and bioinformatics pipeline for WGTA in paediatric cancers, the Personalized OncoGenomics (POG) program, with a focus on potential therapeutic targets.

    • Rebecca J. Deyell
    • Yaoqing Shen
    • Shahrad R. Rassekh
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The interpretation of somatic variants in cancer is challenging due to the scale and complexity of sequencing data. Here, the authors present PORI, an open-source framework for interpreting somatic variants in cancer using graph knowledge base tools, automated reporting, and manual curation.

    • Caralyn Reisle
    • Laura M. Williamson
    • Steven J. M. Jones
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • The meaning of error bars is often misinterpreted, as is the statistical significance of their overlap.

    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 10, P: 921-922

  • Use box plots to illustrate the spread and differences of samples.

    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 11, P: 119-120

  • The needs of the many outweigh the needs of the few. —Mr. Spock (Star Trek II)

    • Christoph F. Kurz
    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 22, P: 638-640

  • Anaerobic digestion of municipal mixed sludge is a microbial-mediated process that produces renewable natural gases such as methane. Here, Kieft et al. present the results of a two-year study of microbial community structure and function at a wastewater treatment plant, shedding light on metabolic interactions between microorganisms in relation with methane production.

    • Brandon Kieft
    • Niko Finke
    • Steven J. Hallam
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Make navigational elements distinct and unobtrusive to maintain visual priority of data.

    • Martin Krzywinski
    News
    Nature Methods
    Volume: 10, P: 183

  • Choose distinct symbols that overlap without ambiguity and communicate relationships in data.

    • Martin Krzywinski
    • Bang Wong
    News
    Nature Methods
    Volume: 10, P: 451

  • Limitations in print resolution and visual acuity impose limits on data density and detail.

    • Martin Krzywinski
    News
    Nature Methods
    Volume: 13, P: 463

  • Relate your data to the world around them using the age-old custom of telling a story.

    • Martin Krzywinski
    • Alberto Cairo
    News
    Nature Methods
    Volume: 10, P: 687

  • Complete maps of DNA methylation in human cells provide insight into the epigenetic regulation of pluripotency.

    • Joseph F Costello
    • Martin Krzywinski
    • Marco A Marra
    News & Views
    Nature Biotechnology
    Volume: 27, P: 1130-1132

  • Carefully designed subplots scaled to the data are often superior to a single complex overview plot.

    • Gregor McInerny
    • Martin Krzywinski
    News
    Nature Methods
    Volume: 12, P: 591

  • Use alignment and consistency to untangle complex circuit diagrams.

    • Barbara Jeanine Hunnicutt
    • Martin Krzywinski
    News
    Nature Methods
    Volume: 13, P: 189

  • Figure labels require the same consistency and alignment in their layout as text.

    • Martin Krzywinski
    News
    Nature Methods
    Volume: 10, P: 275

  • Translate the principles of effective writing to the process of figure design.

    • Martin Krzywinski
    News
    Nature Methods
    Volume: 10, P: 371

  • Visually organize complex data by mapping them onto familiar representations of biological systems.

    • Martin Krzywinski
    • Erica Savig
    News
    Nature Methods
    Volume: 10, P: 595

  • Appeal to intuition when making value judgments

    • Martin Krzywinski
    News
    Nature Methods
    Volume: 13, P: 895

  • Apply visual grouping principles to add clarity to information flow in pathway diagrams.

    • Barbara J Hunnicutt
    • Martin Krzywinski
    News
    Nature Methods
    Volume: 13, P: 5

  • Constraining the magnitude of parameters of a model can control its complexity

    • Jake Lever
    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 13, P: 803-804

  • The P value reported by tests is a probabilistic significance, not a biological one.

    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 10, P: 1041-1042

  • When some factors are harder to vary than others, a split plot design can be efficient.

    • Naomi Altman
    • Martin Krzywinski
    News
    Nature Methods
    Volume: 12, P: 165-166

  • Good experimental designs mitigate experimental error and the impact of factors not under study.

    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 11, P: 699-700

  • The ability to detect experimental effects is undermined in studies that lack power.

    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 10, P: 1139-1140

  • Today's predictions are tomorrow's priors.

    • Jorge López Puga
    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 12, P: 377-378

  • Incorporate new evidence to update prior information.

    • Jorge López Puga
    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 12, P: 277-278

  • Quality is often more important than quantity.

    • Paul Blainey
    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 11, P: 879-880

  • Robustly comparing pairs of independent or related samples requires different approaches to the t-test.

    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 11, P: 215-216

  • When multiple variables are associated with a response, the interpretation of a prediction equation is seldom simple.

    • Martin Krzywinski
    • Naomi Altman
    News
    Nature Methods
    Volume: 12, P: 1103-1104