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Showing 1–6 of 6 results
Advanced filters: Author: Massiullah Shafaq-Zadah Clear advanced filters

  • Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers. These findings suggest that polarized trafficking across the intestinal barrier relies on this glycolipid and lectin (GL-Lect)-mediated endocytosis.

    • Alena Ivashenka
    • Christian Wunder
    • Massiullah Shafaq-Zadah
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15

  • Johannes and colleagues report that retrograde trafficking of non-liganded β1 integrin from the plasma membrane to the trans-Golgi network to then be secreted in a polarized manner is needed for cell adhesion and persistent migration.

    • Massiullah Shafaq-Zadah
    • Carina S. Gomes-Santos
    • Ludger Johannes
    Research
    Nature Cell Biology
    Volume: 18, P: 54-64

  • MacDonald et al. show that EGF triggers de-sialylation of plasma membrane glycoproteins like integrins in a mechanism that depends on the Na+/H+ antiporter NHE1 and the neuraminidases Neu1 and Neu3. Integrins are trafficked to the Golgi and re-sialylated.

    • Ewan MacDonald
    • Alison Forrester
    • Ludger Johannes
    Research
    Nature Cell Biology
    Volume: 27, P: 449-463

  • Endocytosis of the type I interferon receptor (IFNAR) is required for JAK/STAT signalling. Here the authors show that the internalized IFNAR1 and IFNAR2 subunits are differentially sorted by the retromer complex at the early endosome and this controls JAK/STAT signalling and gene transcription.

    • Daniela Chmiest
    • Nanaocha Sharma
    • Christophe Lamaze
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • How and which cell surface molecules are taken up by clathrin-independent endocytosis is an ongoing area of research. Here, the authors show that the tumor marker CD166 is a clathrin-independent cargo that is taken up by endophilin-A3 and galectin-8, which regulates cancer cell migration.

    • Henri-François Renard
    • François Tyckaert
    • Pierre Morsomme
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13