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Showing 1–5 of 5 results
Advanced filters: Author: Mathieu Lavallée-Adam Clear advanced filters

  • The identification of T cell epitopes is a critical step in understanding the immune response to infection and in designing vaccine based approaches. Here the authors introduce a frame work of antigen discovery called MHCvalidator and Epitrack to identify new antigenic features for T-cell COVID-19 vaccines and characterise a novel non-canonical epitope from a truncated Spike variant and mutation of an immunodominant epitope in the BNT162b4 vaccine.

    • Kevin A. Kovalchik
    • David J. Hamelin
    • Etienne Caron
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Some RNA polymerase (POLR) 3-related leukodystrophy cases do not have the causal mutations in POLR3A and POLR3B. Here, by exome sequencing, the authors identify recessive mutations in POLR1C, a gene encoding a shared POLR1 and POLR3 subunit, impairing assembly and nuclear import of POLR3, but not POLR1.

    • Isabelle Thiffault
    • Nicole I. Wolf
    • Geneviève Bernard
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • A new deep proteomic analysis method is used to identify proteins that interact with wild-type cystic fibrosis transmembrane conductance regulator (CFTR) and its mutant version that is the major cause of cystic fibrosis.

    • Sandra Pankow
    • Casimir Bamberger
    • John R. Yates III
    Research
    Nature
    Volume: 528, P: 510-516

  • Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72. Here the authors show that C9ORF72 and the autophagy receptor p62 interact to associate with proteins symmetrically dimethylated on arginines such as FUS, to eliminate stress granules by autophagy.

    • Maneka Chitiprolu
    • Chantal Jagow
    • Derrick Gibbings
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18