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By using a chiral halide perovskite material, spin injection at room temperature into a conventional III–V semiconductor multiple quantum well light-emitting diode is demonstrated, resulting in a semiconductor platform that can also control spin.

X-ray polarimetry observations with the Imaging X-ray Polarimetry Explorer constrain the accretion geometry in an X-ray pulsar and provide evidence for a misalignment of the spin, magnetic and orbital axes in Her X-1.

The study shows that non-linear perceptions of probabilistic rewards explain non-normative information demand in instrumental and noninstrumental conditions, and correlate with personality traits and nonlinearities in risky-choice tasks

Polarization can exceed 60% at the leading edge of the inner part of the Vela pulsar wind nebula; in contrast with the case of the supernova remnant, the electrons in the pulsar wind nebula are accelerated with little or no turbulence in a highly uniform magnetic field.

GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

Hydro-responsive plant movements have provided inspiration for the design of adaptive materials. Harringtonet al. investigate the hydration-dependent unfolding of ice plant seed capsules and find an origami-like folding pattern, which could aid the development of biomimetic folding structures.

Floating offshore wind farms can harvest the steady winds found at sea in locations where the seabed is too deep for fixed-bottom wind turbines. This Perspective explores the technical, industrial and social implications of deploying floating offshore wind on a commercial scale.

The sensing of DNA damage by the AIM2 inflammasome promotes the death of central nervous system cells and is required for normal brain development.

Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors that enable mammalian cells to detect environmental signals and respond by activating user-prescribed transcriptional programs. Here the authors apply synNotch receptors to spatially control differentiation of endothelial and skeletal muscle cells in a multicellular construct on assorted biomaterials.

Extremely low-mass stars, much less massive than the Sun, lack radiative cores—something that could affect their magnetic dynamos. This study reveals that these stars can have magnetic fields that are up to 30% stronger than those of Sun-like stars, implying fundamental differences in their internal magnetic structures.

Grosmark et al. use simultaneous calcium imaging and electrophysiology to track the formation and long-term evolution of hippocampal memory traces in mice and uncover a role for post-learning reactivation in the formation of spatially uniform cognitive maps.

TANK-binding kinase-1 (TBK1) and its homologue IκB kinase-ε (IKKε) are critical in the induction of the interferon response and the response to infection by pathogens. Here the authors show that pharmacological targeting of TBK1 AND IKKε reduces the immunopathology seen in a murine model of SARS-COV-2 infection.

Rustrela virus (RusV) was detected in the brains of 27 out of 29 domestic cats with ‘staggering disease’, but not of 29 control cats. This suggests RusV as the long-sought causative agent of ‘staggering disease’, which had been obscure for 50 years.

The accretion geometry of X-ray binary Cygnus X-3 is determined here from IXPE observations. X-ray polarization reveals a narrow funnel with reflecting walls, which focuses emission, making Cyg X-3 appear as an ultraluminous X-ray source.

Observations from the JWST of the second brightest GRB ever detected, GRB 230307A, indicate that it belongs to the class of long-duration GRBs resulting from compact object mergers, with the decay of lanthanides powering the longlasting optical and infrared emission.

Targeted spatial transcriptomics mapped olfactory receptor mRNAs to sections of the murine olfactory bulb to generate an interactive, statistical, 3D model of glomeruli locations and identify an ultra-sensitive receptor-odorant relationship.

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

A new model of glacial isostatic adjustment used in conjunction with GRACE satellite data suggests that ice loss from Antarctica is contributing 0.19 millimetres per year to global mean sea level, which is substantially less than previous GRACE-based estimates.

NeCLAS is a machine learning pipeline that can accurately and efficiently predict nanoscale interactions, which has broad applications in biological processes and material properties.

Many chemical elements behave quite differently depending on the compound they are found in, but Matt Rattley argues that bromine does so in a particularly striking manner.

MEMS-based photonic integrated circuits (PICs) are often limited in speed by mechanical resonances. Here the authors report a programmable architecture for PICs which uses mechanical eigenmodes for synchronized, resonantly enhanced optical modulation.

Hidden water beneath Antarctica’s ice can accelerate ice loss, potentially raising sea levels by over 2 meters by 2300. These findings highlight the urgent need to incorporate evolving subglacial hydrology into ice sheet models for more accurate sea-level rise projections.

In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or intrinsic noise in adult intestine cells.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

The authors report that the ultrastructure and plasticity of excitatory synapses connecting dentate gyrus and CA3 of the hippocampus are severely compromised in a transchromosomic mouse model of Down syndrome. These alterations are accompanied by unstable information coding by CA3 and CA1 place cells, which may contribute to aspects of impaired cognition in the disease.

Early emission from gamma-ray burst GRB 211211A comes entirely from charged particles accelerating in strong magnetic fields. The fast-evolving spectrum may be the key to understanding unusually long-lived GRBs from neutron star mergers.

Stable chelation of the ¹⁴⁷Pm radionuclide in aqueous solution by the newly synthesized organic diglycolamide ligand is demonstrated and the resulting complex studied, showing accelerated shortening of bonds at the beginning of the lanthanide series.

The cause of high electrical conductivity in the middle crust beneath the Pacific Northwest region of the US is not clear. New electrical-resistivity data reveal a connection between this regional conductor and a localized conductor beneath a prominent volcano in the region, suggesting that the anomalous conductivity is due to the presence of partial melts.

Digenic inheritance of deleterious variants in serine/arginine protein kinase 3 (SRPK3) and titin (TTN) leads to a progressive early onset skeletal muscle myopathy. Zebrafish double mutants exhibit a similar myopathy phenotype accompanied by myofibrillar disorganization.

GWAS in difficult-to-recruit populations identifies variants associated with Lassa fever outcome and susceptibility at loci proximal to LIF, GRM7 and LARGE1.

This paper presents evidence for dynamical interactions in the very dense regions in the core of galaxies causing two compact objects, such as neutron stars and black holes, to merge, leading to a gamma-ray burst.

Kidney injury disrupts the intricate renal architecture and triggers regeneration, inflammation and fibrosis. Here, Polonsky et al. used imaging based spatial transcriptomics (seqFISH) and identified distinct signaling between injured epithelial cells and fibroblasts and initiation of chronic immune responses to kidney injury.

Here the authors identify an association between methylation of the suppressor of cytokine signaling 3 (SOCS3) and height in children from India, Gambia and the UK.

Gelatinous bloom-forming zooplankton—salps—alter microbial communities and quintuple the flux of sinking particles from the surface to the deep, strongly enhancing the ability of the ocean to sequester CO₂.

A solution-based lithography-assisted epitaxial-growth-and-transfer method is used to fabricate single-crystal hybrid perovskites on any surface, with precise control of the thickness, area and chemical composition gradient.

The development of neutralizing antibodies can limit the therapeutic effectiveness of systemically administered oncolytic viruses (OV). Here, to enable repeated intravenous administration, the authors report the development of synthetic RNA viruses formulated within lipid nanoparticles, showing anti-tumor efficacy even in the presence of OV neutralizing antibodies.

A re-examination of the Eocene fish Amphistium and a description of a new genus prove that they are the most primitive members of the flatfish family. In these fish, the migrating eye never gets farther than the dorsal midline, even in fully adult fishes, providing perhaps the most graphic and dramatic examples known of a transitional form spotted in the fossil record.

The potential preservation of viruses in the fossil record is poorly understood. Here, the authors perform metagenomic and microscopic analyses of viruses in living microbial mats and after mineralization, and propose criteria for identifying fossilized viruses.

The detection and modelling of nine X-ray quasi-periodic eruptions from a nearby tidal disruption event shows that these eruptions arise in accretion disks around massive black holes, left behind by tidally disrupted stars, and that an orbiting body colliding with this disk is a plausible explanation for the X-ray variability.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

A colour sensor array based on multilayer monolithically stacked lead halide perovskite thin-film photodetectors achieves higher quantum efficiency and superior colour accuracy compared to conventional filter-based image sensors.

A secure framework that harmonizes storage and querying of clinical and genetic data using blockchain technology was developed to support combined genotype–phenotype queries, improving transparency into how and when health information is used.

Designing electrode architectures for Li-ion batteries that can be reversibly accessible for ion storage can be challenging. Using operando techniques the mechanistic origin of lithiation-induced phase transformations in a V₂O₅ model cathode is now clarified.

JWST detections of Si, C and Fe absorption lines in a bright z = 9.31 galaxy with a two-component clump structure suggest that mergers contributed to the rapid build-up of mass and chemical enrichment soon after the Big Bang.

Credible sustainability certifications require robust evaluation to ensure trustworthiness; however, judgements of sustainable practices may differ between the practitioners and the certifiers. Stakeholder engagement can help bridge this gap to provide robust certification evaluation.

A pulsed illumination scheme renders stimulated Brillouin microscopy less phototoxic and allows imaging of the mechanical properties of sensitive samples such as single cells, Caenorhabditis elegans embryos, zebrafish larvae and organoids.

Platform-based approaches for gene-editing therapies could markedly improve development efficiency, reduce costs and increase access for patients with rare diseases. Although gene editing has shown remarkable clinical success for a small number of Mendelian disease indications, broader adoption faces substantial hurdles. We propose strategies to overcome these challenges through modular platforms for nonclinical and chemistry, manufacturing and controls (CMC) data reuse, risk-based manufacturing quality, and streamlined umbrella clinical trials for regulatory efficiency and accelerated approval.