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Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling

Protease containing ABC Transporters (PCAT) play a critical role in the translocation of polypeptides across membranes. Here, authors reveal the structural and energetic of the ATP-powered conformational cycle that enable this process.

Ruojing Zhang
Kevin L. Jagessar
Hassane S. Mchaourab
ResearchOpen Access20 Oct 2024
Nature Communications

Volume: 15, P: 1-15

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Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling

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