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Probing condensate microenvironments with a micropeptide killswitch

Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells

Yaotian Zhang
Ida Stöppelkamp
Denes Hnisz
ResearchOpen Access04 Jun 2025
Nature

Volume: 643, P: 1107-1116
Large potential reduction in economic damages under UN mitigation targets

If the world can meet the target of limiting global warming to 1.5 °C, economic damage will probably be greatly reduced, especially in poorer countries.

Marshall Burke
W. Matthew Alampay Davis
Noah S. Diffenbaugh
Research23 May 2018
Nature

Volume: 557, P: 549-553
A core viral protein binds host nucleosomes to sequester immune danger signals

Here, a small core protein of human adenoviruses is shown to associate with histones, sequestering proteins on host chromatin and preventing inflammatory proteins from being released and triggering inflammation.

Daphne C. Avgousti
Christin Herrmann
Matthew D. Weitzman
Research29 Jun 2016
Nature

Volume: 535, P: 173-177
A viral biomolecular condensate coordinates assembly of progeny particles

Phase separation of the human adenovirus 52-kDa protein has an essential role in the formation of biomolecular condensates, regulating the coordinated assembly of viral progeny particles.

Matthew Charman
Nicholas Grams
Matthew D. Weitzman
Research05 Apr 2023
Nature

Volume: 616, P: 332-338
Adenovirus-mediated ubiquitination alters protein–RNA binding and aids viral RNA processing

Adenovirus produces two early proteins, E1B55K and E4orf6, that become components of the host cell ubiquitin ligase complex comprising elongin-B and C, cullin-5 and RBX1. The authors identified new protein substrates that are ubiquitinated by the E1B55K–E4orf6 complex and find that hnRNP-C and RALY play an inhibitory role on late viral RNA transcripts and that this is counteracted by ubiquitination due to a reduction on the capacity of these proteins to interact with viral RNA.

Christin Herrmann
Joseph M. Dybas
Matthew D. Weitzman
Research13 Jul 2020
Nature Microbiology

Volume: 5, P: 1217-1231
Author Correction: A viral biomolecular condensate coordinates assembly of progeny particles

Matthew Charman
Nicholas Grams
Matthew D. Weitzman
Amendments and Corrections23 Jun 2023
Nature

Volume: 619, P: E38
Direct RNA sequencing reveals m⁶A modifications on adenovirus RNA are necessary for efficient splicing

Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late mRNAs.

Alexander M. Price
Katharina E. Hayer
Matthew D. Weitzman
ResearchOpen Access26 Nov 2020
Nature Communications

Volume: 11, P: 1-17
Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

A comparative proteomics approach identifies substrates of viral antagonists and reveals host factors that act on viral DNA genomes to restrict infection.

Eui Tae Kim
Joseph M. Dybas
Matthew D. Weitzman
Research11 Jan 2021
Nature Microbiology

Volume: 6, P: 234-245
Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors

AAV vectors are a promising gene delivery vehicle but have a limited DNA packaging capacity. Here, the authors identify cellular restriction factors whose temporary inhibition significantly enhances transduction efficiency of oversized transgenes split into dual AAV vectors.

Anna C. Maurer
Brian Benyamini
Robert Tjian
ResearchOpen Access11 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

Travis H. Stracker
Christian T. Carson
Matthew D. Weitzman
Research18 Jul 2002
Nature

Volume: 418, P: 348-352
Priority for the worse-off and the social cost of carbon

The social cost of carbon (SCC) is usually calculated by an approach that gives less importance to future generations and does not consider well-being distribution. This study presents an alternative that takes these aspects into account.

Matthew Adler
David Anthoff
Nicolas Treich
Research22 May 2017
Nature Climate Change

Volume: 7, P: 443-449
Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

Loss of surface CD19 expression by leukemic cells leads to resistance and relapse to CD19-targeted CAR-T therapies. Here the authors show that loss of SPPL3 in malignant B cells results in hyperglycosylation of CD19.

Amanda Heard
Jack H. Landmann
Nathan Singh
ResearchOpen Access11 Jun 2022
Nature Communications

Volume: 13, P: 1-11
Inactivating intracellular antiviral responses during adenovirus infection

Matthew D Weitzman
David A Ornelles
Reviews21 Nov 2005
Oncogene

Volume: 24, P: 7686-7696
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

Paris et al. show that after injury or influenza infection alveolar type II cells signal via a STAT3–BDNF axis that activates the TrkB receptor on mesenchymal niche cells and enhances alveolar repair.

Andrew J. Paris
Katharina E. Hayer
G. Scott Worthen
Research28 Sept 2020
Nature Cell Biology

Volume: 22, P: 1197-1210
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association

Here, using high spatiotemporal resolution light-sheet and fluorescence microscopy, the authors investigate the role of cytoskeletal components on the intracellular transport of Rab11A and influenza virus (IAV) vRNP), and show a preference for Rab11A movement along microtubules that is not essential for IAV vRNP transport.

Amar R. Bhagwat
Valerie Le Sage
Seema S. Lakdawala
ResearchOpen Access07 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors

Oliver J Müller
Felix Kaul
Martin Trepel
Research03 Aug 2003
Nature Biotechnology

Volume: 21, P: 1040-1046
Breaking the barriers to global gene delivery

Efficient gene delivery to muscles has been achieved with adeno-associated virus 8.

Matthew D Weitzman
Patricia A Thistlethwaite
News & Views01 Mar 2005
Nature Biotechnology

Volume: 23, P: 305-306
Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer

This Perspective addresses next steps to investigate the predictions that inhibition of APOBEC3-mediated mutagenesis may limit tumor heterogeneity, metastasis and drug resistance in a broad range of cancer types by highlighting gaps in our understanding of APOBEC3 biology in cancer and in healthy tissues and strategies to address them.

Mia Petljak
Abby M. Green
Matthew D. Weitzman
Reviews24 Oct 2022
Nature Genetics

Volume: 54, P: 1599-1608
Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

Schlafen proteins are produced in response to interferon signalling, which can be activated by retroviral infection; this study shows that human schlafen 11 inhibits the late stages of HIV-1 production by binding non-specifically to tRNAs, thus preventing the expression of viral proteins.

Manqing Li
Elaine Kao
Michael David
Research23 Sept 2012
Nature

Volume: 491, P: 125-128
Differential L1 regulation in pluripotent stem cells of humans and apes

Induced pluripotent stem-cell characterization reveals phenotypical differences between humans and non-human primates (NHPs): gene expression analysis shows differences in the regulation of long interspersed element-1 (L1) transposons, and in the expression of L1-restricting genes APOBEC3B and PIWIL2, correlating with higher L1 mobility in NHPs; this indicates that L1 mobility differences may have differentially shaped the human and NHP genomes.

Maria C. N. Marchetto
Iñigo Narvaiza
Fred H. Gage
Research23 Oct 2013
Nature

Volume: 503, P: 525-529
The MRE11 complex: starting from the ends

The MRE11 complex mediates repair of DNA double-strand breaks and is essential for genome stability. Structural studies and mouse models are increasing our understanding of how the different components of this complex together coordinate the damage response.

Travis H. Stracker
John H. J. Petrini
Reviews21 Jan 2011
Nature Reviews Molecular Cell Biology

Volume: 12, P: 90-103

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