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Long-term follow-up of participants in the ADVENT trial, which compared pulsed field to conventional thermal ablation in patients with paroxysmal atrial ablation, shows preserved effectiveness of pulsed field ablation over the course of four years.

From lock-in transport measurements of a skyrmion lattice in MnSi, the authors find a delay in the voltage response of the Hall effect and resistivity, arguing that its deformation leads to inertial skyrmion lattice dynamics and emergent reactance.

Researchers develop an adaptive polymer that switches between insulating and conductive states, enabling ultra-efficient electrostatic protection for next-generation electronics at record-low additive content.

KRAS is an oncogene that switches between a GDP-bound inactive state and a GTP-bound active state. Recently developed KRAS G12C inhibitors are specific to the GDP-bound inactive state. Here, the authors develop a class of covalent KRAS G12C inhibitors capable of targeting both states for the treatment of KRAS-driven cancer.

Plasmas can unlock unconventional reactivity for established catalytic systems, but understanding the resulting mechanistic changes is a complex endeavour. Here in situ characterization techniques allow us to rationalize the promotional role of non-thermal plasma on the catalytic hydrogenation of CO₂ to methanol on Cu–Zn systems.

Activity in human dorsal raphe nucleus (DRN)—the main source of serotonin to the human forebrain—signals changes in behavioural policy that are shaped by the distribution of rewards in the environment.

It is unclear whether the harsh abiotic conditions of drylands hinder biological invasions. This global analysis shows that drylands are vulnerable to non-native plants and are likely to become more so as native plant diversity declines and grazing pressure intensifies.

The bacterial genus Aeromonas includes emerging human pathogens, often misidentified as Vibrio cholerae. Here, the authors analyse genomic sequences of over 1,800 Aeromonas isolates, showing that clinical and environmental strains do not display clear differences in drug resistance or disease-causing potential.

Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective and reduces disease-associated paralysis.

Radiation reaction (RR) on particles in strong fields is the subject of intense experimental research, but previous efforts lacked statistical significance due to the extreme regimes required. Here, the authors report a 5σ observation of RR and obtain strong, quantitative evidence favouring quantum models over classical, using an all-optical setup where electrons are accelerated by a laser in a gas jet before colliding with a second, intense pulse.

A human spinal cord organoid model can replicate two different types of spinal cord injury and can be used as an in vitro system to evaluate therapeutics and inflammatory reactions to treatments.

Most active particles studied to date lack the ability to undergo controlled shape transformations and control over their propulsion in response to environmental stimuli. Here, the authors present a class of active particles made from stimuli-responsive materials that exhibit fully reversible shape-dependent propulsion.

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions.

The relation between magnetooptical activity and chirality has previously been confused. Chiral polymer films are presented with state-of-the-art Verdet constants, revealing the role of chirality, and a strategy to enhance the magnetooptical B term.

Polymer thin films that emit and absorb circularly polarised light are promising in achieving important technological advances, but the origin of the large chiroptical effects in such films has remained elusive. Here the authors demonstrate that in non-aligned polymer thin films, large chiroptical effects are caused by magneto-electric coupling, not structural chirality as previously assumed.

A van der Waals heterostructure made from atomic layers of ferroelectric CuCrP₂S₆ and ferromagnetic Fe₃GeTe₂ can offer reversible, non-volatile ferroelectric control of two-dimensional magnetism.

A new platform comprising large-scale 2D arrays of quantum dots patterned with sub-nanometre precision, with each quantum dot defined by tens of phosphorus atoms doped into silicon, allows for analogue simulation of quantum materials on arbitrary lattices.

This study introduces a semi-automated, scalable whole-brain mapping workflow that enables unbiased comparisons across cohorts, revealing widespread temporally and sexually distinct regional activation patterns after acute morphine exposure in mice.

A completely solid-state, single-chip, microwave-frequency surface acoustic wave phonon laser can generate coherent phonons from thermal noise or resonantly amplify injected phonons using only a direct current bias field.

A plasma lens capable of focusing broadband extreme-ultraviolet attosecond pulses is demonstrated.

Spatiotemporal insight into photoactivation of the prototypical B₁₂ photoreceptor CarH is revealed across nine orders of magnitude in time, identifying a transient adduct that distinguishes it from thermally activated B₁₂ enzymes.

Prenatal Zika virus (ZIKV) exposure can lead to a spectrum of developmental issues, but the mechanisms remain unclear. Here the authors show that prenatal ZIKV exposure in macaques disrupts neurodevelopment, causing prolonged maternal attachment and visual deficits at 3 months that normalize by 12 months, independent of sensory function.

Complex infectious conditions, such as sepsis, requires rapid assessment of both pathogens and host responses. Here, the authors develop MIDAS, an assay platform that profiles bacterial RNA and inflammatory proteins simultaneously in under 4 hours.

Building scalable quantum technologies requires generating robust many-body entanglement in solid-state platforms. This Review highlights how engineered light–matter interactions, optical nonlinearities and coupling to nanophotonic structures enable coherent many-body entangled states that are resilient to disorder and decoherence.

Projected impacts of climate change on malaria burden in Africa by 2050 highlight the urgent need for climate-resilient malaria control strategies and robust emergency response systems to safeguard progress towards malaria eradication.

Chemical recycling of poly(methyl methacrylate) (PMMA) typically requires high temperatures. Here, the authors report the UV-initiated depolymerisation of PMMA at low temperatures, in non-chlorinated solvents, such as benzonitrile.

MedHELM, an extensible evaluation framework including a new taxonomy for classifying medical tasks and a benchmark of many datasets across these categories, enables the evaluation of large language models on real-world clinical tasks.

The spin-orbit coupling present in certain nonmagnetic/ferromagnetic metal bilayers could enable electrical control of pure spin currents in future spintronic devices. Xiao et al. report the signatures of such coupling, even when the two layers are separated by a third copper layer.

The spatial and temporal control of material properties at a distance have been so far achieved with light, heat, or sound. Here, the authors control chemical reactions and further polymerization of composites with an electric field via inverse piezo-effect resulting in multi-stiffness gels.

The authors demonstrate dual-probe multi-messenger imaging of high-energy-density plasmas based on laser-wakefield-accelerated electrons. This enables spatiotemporally resolved simultaneous probing of plasma hydrodynamics and electromagnetic field evolution with both x-ray and electron beams.

The authors study epitaxial thin films of the pyrochlore-sublattice compound LiTi2O4 by RIXS and ARPES. They observe cooperation between strong electron correlations and strong electron-phonon coupling, giving rise to a mobile polaronic ground state in which charge motion and lattice distortions are coupled.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunotherapies.

Reported detections of gases in exoplanet atmospheres, including claims of biosignatures on K2-18 b, disappear when broader models are tested, revealing that such detections often reflect modelling limits rather than real signals.

The LGN is a critical stage between the retina and visual cortex, but the properties of human LGN neurons are not fully understood. Here the authors report that they closely resemble those in monkeys and that closure of one eye increases the activity of putative inhibitory neurons connected to that eye.

A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

A multitrait fine-mapping method, mvSuSiE, improves power and resolution over single-trait methods for identifying putative causal variants from genetic association data.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Whether high-order frontal lobe areas receive raw speech input in parallel with early speech areas in the temporal lobe is unclear. Here, the authors show that frontal lobe areas get fast low-level speech information in parallel with temporal lobe speech areas.

During plant cultivation, denitrification process can release greenhouse gas nitrous oxide (N₂O) to atmosphere. Here, the authors develop a soybean–bradyrhizobial symbiosis system with enhanced capacity to reduce N₂O emissions using the incompatibility between two soybean R genes and their effector present in bradyrhizobia.

Structural, genetic, functional and biochemical analyses of the complex flagellar motor of Campylobacter jejuni reveal structural adaptations with an ancient origin also found more widely across bacterial species, including elements exapted from the type IV pilus machinery.

Here, the authors examine the mechanisms behind cheatgrass’s successful invasion of North American ecosystems. Their genetic analyses and common garden experiments demonstrate that multiple introductions and migrations facilitated cheatgrass local adaptation.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.