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Showing 1–50 of 102 results
Advanced filters: Author: Matthew J Simmons Clear advanced filters
    • Nina Veselka
    • David D. McErlain
    • M. Brock Fenton
    Research
    Nature
    Volume: 466, P: E9
  • Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

    • Alexandre R. Zuntini
    • Tom Carruthers
    • William J. Baker
    ResearchOpen Access
    Nature
    Volume: 629, P: 843-850
  • Targeting CD8+ T cell exhaustion is a strategy to enhance immune checkpoint inhibition and to fight cancer. Here the authors show a NRF2-dependent role for the prostaglandin I2 receptor PTGIR in controlling T cell exhaustion.

    • Michael S. Dahabieh
    • Lisa M. DeCamp
    • Russell G. Jones
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1139-1151
  • Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

    • Harry Pickering
    • Joanna Schaenman
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

    • Benjamin S. Haslund-Gourley
    • Kyra Woloszczuk
    • Mary Ann Comunale
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19
  • Donor spin states in silicon are good quantum bit candidates due to their long coherence times. Here, the authors use radio frequency reflectometry to measure singlet and triplet states, and to determine the tunnel coupling between few-donor silicon double quantum dots and the electrical leads.

    • M. G. House
    • T. Kobayashi
    • M. Y. Simmons
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-6
  • Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

    • Al Ozonoff
    • Naresh Doni Jayavelu
    • Nadine Rouphael
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17
  • Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendocrine cells provide metabolic support, driving a tumour-autonomous cycle that enhances tumorigenesis and metastasis.

    • Paola Peinado
    • Marco Stazi
    • Leanne Li
    ResearchOpen Access
    Nature
    Volume: 639, P: 765-775
  • Sorption modeling treating soil as a homogenous medium misrepresents PFAS mobility in the subsurface. Exploring minerals reveals the role of aluminum-oxide electrostatics for short PFAS and organic matter and air-water interface for long-chains.

    • Marina G. Evich
    • James Ferreira
    • John W. Washington
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Multi-donor molecules in Si provide a promising qubit platform, offering advantages over single donor qubits in terms of performance and fabrication. Here, the authors report a single qubit gate and long coherence times in a P donor molecule qubit in natural Si patterned by scanning tunneling microscope hydrogen lithography.

    • Lukas Fricke
    • Samuel J. Hile
    • Michelle Y. Simmons
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-6
  • Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

    • Claudia L. Satizabal
    • Hieab H. H. Adams
    • M. Arfan Ikram
    Research
    Nature Genetics
    Volume: 51, P: 1624-1636
  • Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

    • Damaris Kinyoki
    • Aaron E. Osgood-Zimmerman
    • Simon I. Hay
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 1761-1782
  • This mega-analysis of brain resting-state functional connectivity in young individuals with major depressive disorder scanned at six sites across four countries identified hub regions of the attentional and default mode networks as predictors of depression severity.

    • Nga Yan Tse
    • Aswin Ratheesh
    • Andrew Zalesky
    Research
    Nature Mental Health
    Volume: 2, P: 1169-1182
  • Age-associated B cells (ABC) have been shown to be associated with autoimmunity and ageing. Here the authors examine whether ABC are transcriptionally or functionally altered in participants with reduced immune cell function and show that, being transcriptionally similar, high pre-vaccine levels are associated with poor vaccine response.

    • Juan Carlos Yam-Puc
    • Zhaleh Hosseini
    • James E. D. Thaventhiran
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • A catalogue of the vascular flora of New Guinea indicates that this island is the most floristically diverse in the world, and that 68% of the species identified are endemic to New Guinea.

    • Rodrigo Cámara-Leret
    • David G. Frodin
    • Peter C. van Welzen
    Research
    Nature
    Volume: 584, P: 579-583
  • Aegilops sharonensis is a wild diploid relative of wheat. Here, the authors assemble the genome of Ae. sharonensis and use the assembly as an aid to clone the Ae. sharonensis-derived stem rust resistance gene Sr62 in the allohexaploid genome of wheat.

    • Guotai Yu
    • Oadi Matny
    • Brande B. H. Wulff
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • This study supports neurofilament light chain protein (NfL) in both cerebrospinal fluid (CSF) and blood as an early marker of neurodegeneration in Alzheimer’s disease but suggests that NfL in CSF may be better suited than blood for monitoring clinical trial outcomes in symptomatic patients.

    • Anna Hofmann
    • Lisa M. Häsler
    • Jinbin Xu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10
  • Spin qubits in systems with strong spin–orbit coupling can be electrically controlled, but are usually affected by short coherence times. Here, coherence times up to 10 ms are obtained for strain-engineered hole states bound to boron acceptors in silicon 28.

    • Takashi Kobayashi
    • Joseph Salfi
    • Sven Rogge
    Research
    Nature Materials
    Volume: 20, P: 38-42
  • Whole-genome alignment of 239 primate species reveals noncoding regulatory elements that are under selective constraint in primates but not in other placental mammals, that are enriched for variants that affect human gene expression and complex traits in diseases.

    • Lukas F. K. Kuderna
    • Jacob C. Ulirsch
    • Kyle Kai-How Farh
    ResearchOpen Access
    Nature
    Volume: 625, P: 735-742
  • Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.

    • Dawn M. Dudley
    • Matthew T. Aliota
    • David H. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9
  • The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

    • Derrek P. Hibar
    • Hieab H. H. Adams
    • M. Arfan Ikram
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12
  • A variant telomerase template demonstrates that human telomeres can tolerate significant degeneracy and remain functional. Once incorporated by telomerase, variant sequences can influence telomere length dynamics.

    • Angela M. Hinchie
    • Samantha L. Sanford
    • Jonathan K. Alder
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Echolocation is usually associated with bats. Many echolocating bats produce signals in the larynx, but a few species produce tongue clicks. Here, studies show that in all bats that use larynx-generated clicks, the stylohyal bone is connected to the tympanic bone. Study of the stylohyal and tympanic bones of a primitive fossil bat indicates that this species may have been able to echolocate, despite previous evidence to the contrary, raising the question of when and how echolocation evolved in bats.

    • Nina Veselka
    • David D. McErlain
    • M. Brock Fenton
    Research
    Nature
    Volume: 463, P: 939-942
  • Therapeutic options for small cell lung cancer (SCLC) are limited. Here the authors show that a telomere-targeting drug, 6-Thio-2’-deoxyguanosine, inhibits growth of SCLC tumors by inducing telomere dysfunction preferentially in cancer initiating cells and promoting anti-tumor immune responses.

    • Buse Eglenen-Polat
    • Ryan R. Kowash
    • Esra A. Akbay
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Warming ocean water plays a significant role in accelerating Arctic sea ice melt. Here the authors present detailed observations of warm water of Pacific origin entering and diving beneath the Arctic ocean surface, and explore the dynamical processes governing its evolution.

    • Jennifer A. MacKinnon
    • Harper L. Simmons
    • Kevin R. Wood
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12
  • A genomic and transcriptomic analysis of 2,754 childhood acute lymphoblastic leukemias identifies 376 putative driver genes, and associations between disease subtypes and prognosis.

    • Samuel W. Brady
    • Kathryn G. Roberts
    • Charles G. Mullighan
    Research
    Nature Genetics
    Volume: 54, P: 1376-1389
  • Understanding the effect of vaccination on emerging SARS-CoV-2 variants of concern is of increasing importance. Here, James et al. report that two doses of vaccination with the Pfizer-BioNTech vaccine induce more robust immune responses to the B.1.1.7 and B.1.351 SARS-CoV-2 lineages than does natural infection.

    • Donal T. Skelly
    • Adam C. Harding
    • William S. James
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12
  • SMARCB1 is frequently lost in solid cancer and reported to support tumourigenesis through STAT3 activation. Here, the authors show in several preclinical models that targeting IL6/JAK/STAT3 molecular pathway is a potential therapeutic approach for SMARCB1-deficient bladder cancer.

    • Chandra Sekhar Amara
    • Karthik Reddy Kami Reddy
    • Nagireddy Putluri
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Whole-genome analysis of oestrogen-receptor-positive tumours in patients treated with aromatase inhibitors show that distinct phenotypes are associated with specific patterns of somatic mutations; however, most recurrent mutations are relatively infrequent so prospective clinical trials will require comprehensive sequencing and large study populations.

    • Matthew J. Ellis
    • Li Ding
    • Elaine R. Mardis
    ResearchOpen Access
    Nature
    Volume: 486, P: 353-360
  • Internal oceanic waves are subsurface gravity waves that can be enormous and travel thousands of kilometres before breaking but they are difficult to study; here observations of such waves in the South China Sea reveal their formation mechanism, extreme turbulence, relationship to the Kuroshio Current and energy budget.

    • Matthew H. Alford
    • Thomas Peacock
    • Tswen-Yung (David) Tang
    Research
    Nature
    Volume: 521, P: 65-69
  • Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

    • Eva Gonçalves Serra
    • Tobias Schwerd
    • Carl A. Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • The engagement of immunological memory is a key component to the protective anti-SARS-CoV-2 B and T cell responses. Here the authors assess the B and T cells of a cohort of UK healthcare workers in response to infection and longitudinally track the compartment showing distinct trajectories following early priming.

    • Adriana Tomic
    • Donal T. Skelly
    • Susanna J. Dunachie
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20
  • Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.

    • Paloma Cejas
    • Yingtian Xie
    • Henry W. Long
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11
  • The venomous stinging cells of jellyfish, anemones, and corals contain an organelle, the nematocyst, which explosively discharges a venom-laden thread. Here, the authors describe the nematocyst thread and its sub-structures in the sea anemone N. vectensis, revealing a complexity and sophistication underpinning this cellular weapon.

    • Ahmet Karabulut
    • Melainia McClain
    • Matthew C. Gibson
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12