Nature Search

Viral gene drive spread during herpes simplex virus 1 infection in mice

Gene drives are genetic modifications designed to propagate efficiently through a population. Here, the authors develop a viral gene drive against herpes simplex virus 1 (HSV-1) and show that it propagates efficiently during HSV-1 infection in mice.

Marius Walter
Anoria K. Haick
Eric Verdin
ResearchOpen Access17 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Exposure and survival of wild raptors during the 2022–2023 highly pathogenic influenza a virus outbreak

Kelsey M. Rayment
Dana Franzen-Klein
Victoria Hall
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity

Lineage plasticity is increasingly recognized as an emergent resistance mechanism after treatment with androgen receptor signalling inhibitors. To understand determinants of resistance, the authors analyzed the transcriptomes of patient tumor biopsies before enzalutamide treatment and at progression and identified a gene expression program associated with lineage plasticity risk and poor outcomes.

Thomas C. Westbrook
Xiangnan Guan
Joshi J. Alumkal
ResearchOpen Access15 Sept 2022
Nature Communications

Volume: 13, P: 1-13
Salmonid sensory system development is affected by climate change driven temperature increases

Aubree E. Jones
Matthew J. O’Donnell
Jacqueline F. Webb
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

Nicole King
M. Jody Westbrook
Daniel Rokhsar
ResearchOpen Access14 Feb 2008
Nature

Volume: 451, P: 783-788
Exposure to Gulf war illness-related chemicals exacerbates alcohol-induced liver damage in rodents

Anca D. Petrescu
Juliet Venter
Sharon DeMorrow
ResearchOpen Access01 Jul 2024
Scientific Reports

Volume: 14, P: 1-18
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

This study investigates the effects of MYCN on the chromatin and transcriptional landscape of neuroblastoma. The authors find that, at oncogenic levels, MYCN binds to canonical E-boxes at promoters and invades enhancers, leading to transcriptional amplification.

Rhamy Zeid
Matthew A. Lawlor
James E. Bradner
Research29 Jan 2018
Nature Genetics

Volume: 50, P: 515-523
FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models

Weeden et al. use a method called FORCE to deliver oligonucleotides to muscle and evaluate the platform’s utility in models of myotonic dystrophy. An antisense oligonucleotide targeting DMPK is guided to muscle tissue with an antibody fragment and beneficial results are seen in mouse models of disease and cynomolgus monkey.

Timothy Weeden
Tyler Picariello
Stefano Zanotti
ResearchOpen Access18 Jan 2025
Communications Medicine

Volume: 5, P: 1-18
Computational design of small transcription activating RNAs for versatile and dynamic gene regulation

The structural basis of RNA-based gene control offers the possibility of de novo design. Here the authors present a computational design approach for Small Transcription Activating RNAs a bacterial RNA regulator that allows for versatile and dynamic control of genes, pathways and genetic circuits.

James Chappell
Alexandra Westbrook
Julius B. Lucks
ResearchOpen Access19 Oct 2017
Nature Communications

Volume: 8, P: 1-12
Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis

Anca D. Petrescu
Stephanie Grant
Sharon DeMorrow
ResearchOpen Access29 Sept 2020
Scientific Reports

Volume: 10, P: 1-19
Optimized sample buffer for dispersed, high-resolution capillary zone electrophoretic separation of Escherichia coli B

Bonnie Jaskowski Huge
Caitlin M. Kerr
Norman J. Dovichi
ResearchOpen Access14 Dec 2023
Scientific Reports

Volume: 13, P: 1-11
Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale

Chulmin Cho
Vassilia Michailidis
Loren J. Martin
ResearchOpen Access23 Jan 2019
Scientific Reports

Volume: 9, P: 1-9
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.

Amritha Nair
Hsiang-Ching Chung
Thomas F Westbrook
Research26 Mar 2018
Nature Medicine

Volume: 24, P: 505-511
Gulf war illness-related chemicals increase CD11b/c⁺ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model

Anca D. Petrescu
Stephanie Grant
Sharon DeMorrow
ResearchOpen Access03 Sept 2018
Scientific Reports

Volume: 8, P: 1-13
Early brain injury and cognitive impairment after aneurysmal subarachnoid haemorrhage

Matthew J. Rowland
Payashi Garry
Kyle T. S. Pattinson
ResearchOpen Access01 Dec 2021
Scientific Reports

Volume: 11, P: 1-11
Extracorporeal life support without systemic anticoagulation: a nitric oxide-based non-thrombogenic circuit for the artificial placenta in an ovine model

Brian P. Fallon
Orsolya Lautner-Csorba
George B. Mychaliska
Research22 Apr 2023
Pediatric Research

Volume: 95, P: 93-101
Mapping the incidentalome: estimating incidental findings generated through clinical pharmacogenomics testing

Matthew J. Westbrook
M. Frances Wright
Kyle B. Brothers
Reviews29 Nov 2012
Genetics in Medicine

Volume: 15, P: 325-331
Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology

Corinne Renier
Edward Pao
Elodie Sollier-Christen
ResearchOpen Access08 May 2017
npj Precision Oncology

Volume: 1, P: 1-11
Correction: Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation

Jan W. van der Scheer
Victoria Komolafe
Mary Dixon-Woods
Amendments and CorrectionsOpen Access24 Feb 2025
Pediatric Research

Volume: 97, P: 2491
Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation

Jan W. van der Scheer
Victoria Komolafe
Mary Dixon-Woods
ResearchOpen Access30 Jan 2025
Pediatric Research

Volume: 98, P: 853-863
Eliciting preferences on secondary findings: the Preferences Instrument for Genomic Secondary Results

Kyle B. Brothers
Kelly M. East
Ellen Wright Clayton
Research25 Aug 2016
Genetics in Medicine

Volume: 19, P: 337-344

Search

Viral gene drive spread during herpes simplex virus 1 infection in mice

Exposure and survival of wild raptors during the 2022–2023 highly pathogenic influenza a virus outbreak

Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity

Salmonid sensory system development is affected by climate change driven temperature increases

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

Exposure to Gulf war illness-related chemicals exacerbates alcohol-induced liver damage in rodents

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models

Computational design of small transcription activating RNAs for versatile and dynamic gene regulation

Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis

Optimized sample buffer for dispersed, high-resolution capillary zone electrophoretic separation of Escherichia coli B

Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Gulf war illness-related chemicals increase CD11b/c⁺ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model

Early brain injury and cognitive impairment after aneurysmal subarachnoid haemorrhage

Extracorporeal life support without systemic anticoagulation: a nitric oxide-based non-thrombogenic circuit for the artificial placenta in an ovine model

Mapping the incidentalome: estimating incidental findings generated through clinical pharmacogenomics testing

Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology

Correction: Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation

Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation

Eliciting preferences on secondary findings: the Preferences Instrument for Genomic Secondary Results

Search

Quick links

Search

Filter By:

Search

Quick links