Nature Search

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans

Stunnenberg et al. use a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppressed phases of systemic inflammation.

Farid Keramati
Guus P. Leijte
Matthijs Kox
ResearchOpen Access18 Apr 2025
Nature Immunology

Volume: 26, P: 737-747
The immunology of sepsis: translating new insights into clinical practice

The authors discuss the dysregulated host response in sepsis and the use of biomarkers to gauge the immunological status of patients and potentially guide precision medicine. They also highlight potential immunomodulatory therapies for sepsis and discuss the future of sepsis clinical trials.

Matthijs Kox
Michael Bauer
Peter Pickkers
Reviews24 Sept 2025
Nature Reviews Nephrology

P: 1-20
Measuring mitochondrial oxygenation and respiration during systemic inflammation in humans in vivo

Mark A. Wefers Bettink
Jelle Zwaag
Egbert G. Mik
ResearchOpen Access16 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Morphology-dependent zeolite intergrowth structures leading to distinct internal and outer-surface molecular diffusion barriers

Characterizing the internal architecture of zeolites is crucial for understanding their structure–function relationships, and for acid–base heterogeneous catalysis. Using a unique combination of diffraction and microscopy techniques provides a unified picture of the morphology of intergrowth structures and confirmation of surface barriers for molecular diffusion.

Lukasz Karwacki
Marianne H. F. Kox
Bert M. Weckhuysen
Research20 Sept 2009
Nature Materials

Volume: 8, P: 959-965
Swarm Learning for decentralized and confidential clinical machine learning

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Stefanie Warnat-Herresthal
Hartmut Schultze
Joachim L. Schultze
ResearchOpen Access26 May 2021
Nature

Volume: 594, P: 265-270
Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

A nanoparticle integrating a fusion protein of apolipoprotein A1 and interleukin-4 and that targets myeloid-cell-rich haematopoietic organs resolves immunoparalysis in ex vivo and in vivo models of sepsis.

David P. Schrijver
Rutger J. Röring
Willem J. M. Mulder
ResearchOpen Access08 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 1097-1112
A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

Emma J. Kooistra
Aline H. de Nooijer
Irma Joosten
Research25 Jan 2021
International Journal of Obesity

Volume: 45, P: 687-694
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Sepsis is poorly understood, largely untreatable and frequently fatal. Netea and colleagues assess both mouse sepsis and human sepsis to demonstrate that its late phase is characterized by immunoparalysis and broad metabolic alterations in cells of the immune system.

Shih-Chin Cheng
Brendon P Scicluna
Mihai G Netea
Research07 Mar 2016
Nature Immunology

Volume: 17, P: 406-413
Preclinical and first-in-human safety studies on a novel magnetism-based haemofiltration method

Nicole Waalders
Dirk van Lier
Peter Pickkers
ResearchOpen Access18 Jun 2024
Scientific Reports

Volume: 14, P: 1-15
Mathematical model of the inflammatory response to acute and prolonged lipopolysaccharide exposure in humans

Freek J. A. Relouw
Matthijs Kox
Natal A. W. van Riel
ResearchOpen Access05 Dec 2024
npj Systems Biology and Applications

Volume: 10, P: 1-11
Ethylene, an early marker of systemic inflammation in humans

Laurent M. Paardekooper
Geert van den Bogaart
Simona M. Cristescu
ResearchOpen Access31 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia

Dorien Kiers
Jelle Gerretsen
Matthijs Kox
ResearchOpen Access30 Nov 2015
Scientific Reports

Volume: 5, P: 1-11
Mechanical ventilation of mice under general anesthesia during experimental procedures

Ilona van den Brink
Francien van de Pol
Gert Jan Scheffer
Special Features19 Jun 2013
Lab Animal

Volume: 42, P: 253-257

Search

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans

The immunology of sepsis: translating new insights into clinical practice

Measuring mitochondrial oxygenation and respiration during systemic inflammation in humans in vivo

Morphology-dependent zeolite intergrowth structures leading to distinct internal and outer-surface molecular diffusion barriers

Swarm Learning for decentralized and confidential clinical machine learning

Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Preclinical and first-in-human safety studies on a novel magnetism-based haemofiltration method

Mathematical model of the inflammatory response to acute and prolonged lipopolysaccharide exposure in humans

Ethylene, an early marker of systemic inflammation in humans

Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia

Mechanical ventilation of mice under general anesthesia during experimental procedures

Search

Quick links

Search

Filter By:

Search

Quick links