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Correction: Corrigendum: Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

Ineke Brouwer
Gerrit Sitters
Gijs J. L. Wuite
Amendments and Corrections22 Mar 2017
Nature

Volume: 543, P: 742
Ku limits RNA-induced innate immunity to allow Alu expansion in primates

Studies on the essentiality of Ku in human cells reveal that Ku interacts with diverse double-stranded RNA molecules, including antisense Alu, and enables tolerance of Alu sequence expansion in primates.

Yimeng Zhu
Angelina Li
Shan Zha
Research15 May 2025
Nature

Volume: 643, P: 562-571
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

What is the role of disorder in non-homologous end-joining proteins? The authors use nuclear magnetic resonance to reveal that disordered regions mediate a network of multivalent interactions, promoting biomolecular condensation that accelerates DNA ligation kinetics.

Duc-Duy Vu
Alessio Bonucci
Fabien Ferrage
Research19 Jun 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1732-1744
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

A combination of single-molecule techniques shows that the repair proteins XRCC4 and XLF form heteromeric mobile sleeve-like complexes that can bridge and hold together fragments of broken DNA.

Ineke Brouwer
Gerrit Sitters
Gijs J. L. Wuite
Research20 Jul 2016
Nature

Volume: 535, P: 566-569
Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

DNA strand exchange results in a physical linkage between two homologous DNAs. The RecA/RAD51 family of ATPases mediates strand exchange by forming a long filament on the DNA. This paper uses a single-molecule approach to elucidate how the filament is disassembled once the strands are exchanged, and how this process relates to the energy released by nucleotide hydrolysis.

Joost van Mameren
Mauro Modesti
Gijs J. L. Wuite
Research07 Dec 2008
Nature

Volume: 457, P: 745-748
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

Replication stress has been associated with transient remodelling of replication intermediates into reversed forks, followed by efficient fork restart. Here the authors systematically analyse the role of RAD51 paralogs in these transactions, providing insights on the mechanistic role of different complexes of these proteins.

Matteo Berti
Federico Teloni
Massimo Lopes
ResearchOpen Access15 Jul 2020
Nature Communications

Volume: 11, P: 1-12
Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex

Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. Here the authors reveal roles for the mouse SWS1–SWSAP1–SPIDR complex in inter-homolog recombination, including during meiosis, and sister chromatid exchange in BLM helicase deficient cells.

Rohit Prakash
Thomas Sandoval
Maria Jasin
ResearchOpen Access12 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

In the genome, repetitive guanine-rich sequences have the potential to spontaneously fold into non-canonical DNA secondary structures known as G-quadruplex (G4). Using novel single-molecule imaging approaches, the authors reveal that G4 formation within active replication forks locally perturb replisome dynamics and damage response signaling, which require RPA and FANCJ for regulation.

Wei Ting C. Lee
Yandong Yin
Eli Rothenberg
ResearchOpen Access05 May 2021
Nature Communications

Volume: 12, P: 1-14
Reconstitution of anaphase DNA bridge recognition and disjunction

Single-molecule and biochemistry approaches are used to investigate how ultra-fine DNA bridges, which form between sister chromatids during anaphase, are recognized and processed by cellular factors PICH, BLM, TopoIIIα and RPA.

Kata Sarlós
Andreas S. Biebricher
Ian D. Hickson
Research03 Sept 2018
Nature Structural & Molecular Biology

Volume: 25, P: 868-876
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

Crystal structures of the Ku70/80–DNA complex with Ku binding motifs of APLF and XLF reveal distinct interaction sites and an induced conformational change in Ku80 critical for function in NHEJ repair.

Clement Nemoz
Virginie Ropars
Jean Baptiste Charbonnier
Research05 Oct 2018
Nature Structural & Molecular Biology

Volume: 25, P: 971-980
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
ExoMeg1: a new exonuclease from metagenomic library

Rita C. B. Silva-Portela
Fabíola M. Carvalho
Lucymara F. Agnez-Lima
ResearchOpen Access27 Jan 2016
Scientific Reports

Volume: 6, P: 1-11
STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway

Laura Cheradame
Ida Chiara Guerrera
Vincent Goffin
Research08 Oct 2021
Oncogene

Volume: 40, P: 6627-6640
Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface

Grégory Menchon
Oriane Bombarde
Patrick Calsou
ResearchOpen Access11 Mar 2016
Scientific Reports

Volume: 6, P: 1-13

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Correction: Corrigendum: Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

Ku limits RNA-induced innate immunity to allow Alu expansion in primates

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

Diminishing benefits of urban living for children and adolescents’ growth and development

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

Reconstitution of anaphase DNA bridge recognition and disjunction

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

ExoMeg1: a new exonuclease from metagenomic library

STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface

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