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Showing 1–17 of 17 results
Advanced filters: Author: Max Rimmer Clear advanced filters

  • HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

    • Sonali Andani
    • Boqi Chen
    • Gunnar Rätsch
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 1292-1307

  • Low stellar ultraviolet (UV) radiation leads to low ozone abundances, therefore, less planetary UV protection. Here, the authors show that planets in the habitable zones of metal-poor stars, despite their higher UV radiation than metal-rich stars, are the best targets for search for life.

    • Anna V. Shapiro
    • Christoph Brühl
    • Jos Lelieveld
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

    • Nicola Miglino
    • Nora C. Toussaint
    • Andreas Wicki
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2430-2441

  • Observations from the JWST show the presence of a spectral absorption feature at 4.05 μm arising from SO2 in the atmosphere of the gas giant exoplanet WASP-39b, which is produced by photochemical processes and verified by numerical models.

    • Shang-Min Tsai
    • Elspeth K. H. Lee
    • Sergei N. Yurchenko
    ResearchOpen Access
    Nature
    Volume: 617, P: 483-487

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • High-temperature proton exchange membrane fuel cells offer efficient solutions to complex fuel cell challenges, including fuel flexibility and heat management. Here the authors demonstrate that laser-scribed membranes improve fuel cell durability and boost peak power density by over 50%, providing a more stable and scalable approach for high performance fuel cells.

    • Jianuo Chen
    • Xuekun Lu
    • Thomas S. Miller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Long-read single-cell RNA sequencing is capable of detecting isoform-level gene expression and genomic alterations such as mutations and gene fusions, thereby providing cell-specific genotype-phenotype information. Here, the authors use long-read scRNA-seq on metastatic ovarian cancer samples and detect cell-type specific isoforms and gene fusions that may otherwise be misclassified in short-read data.

    • Arthur Dondi
    • Ulrike Lischetti
    • Niko Beerenwinkel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

    • Rebekka Wegmann
    • Ximena Bonilla
    • Alexandre P. A. Theocharides
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • This report from the 1000 Genomes Project describes the genomes of 1,092 individuals from 14 human populations, providing a resource for common and low-frequency variant analysis in individuals from diverse populations; hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites, can be found in each individual.

    • Gil A. McVean
    • David M. Altshuler (Co-Chair)
    • Gil A. McVean
    ResearchOpen Access
    Nature
    Volume: 491, P: 56-65

  • Results for the final phase of the 1000 Genomes Project are presented including whole-genome sequencing, targeted exome sequencing, and genotyping on high-density SNP arrays for 2,504 individuals across 26 populations, providing a global reference data set to support biomedical genetics.

    • Adam Auton
    • Gonçalo R. Abecasis
    • Gonçalo R. Abecasis
    ResearchOpen Access
    Nature
    Volume: 526, P: 68-74

  • 1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

    • Olivier Delaneau
    • Jonathan Marchini
    • Leena Peltonenz
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • Angstrom-scale two-dimensional channel devices can be assembled with precise control over their dimensions, as a single channel or hundreds of channels using layered crystals, and enable the measurement of angstrom-scale gas, ion and water fluidics.

    • Ankit Bhardwaj
    • Marcos Vinicius Surmani Martins
    • Ashok Keerthi
    Protocols
    Nature Protocols
    Volume: 19, P: 240-280