Two and three times repeats of the self-assembling peptide RADA16 (RADARADARADARADA), namely RADA16x2 and RADA16x3, were genetically produced. The peptides were expressed as fusion proteins while retaining the activity of the fusion partner protein. The expressed peptides exhibited both fibril formation and cell adhesive activity. Moreover, the hydrogels formed by the peptides via addition of a medium provided a three-dimensional environment for cell proliferation.
- Masayasu Mie
- Mayu Oomuro
- Eiry Kobatake