By characterizing APOB-reactive CD4+ T cells in patients with atherosclerosis, Roy et al. identify effector regulatory T (eTreg) cells as the predominant autoreactive subset. These APOB-specific eTreg cells are clonally expanded, express the plaque-homing receptor CXCR6 and progressively lose their regulatory phenotype as disease severity increases.
- Payel Roy
- Anusha Bellapu
- Klaus Ley