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T817MA protects against inflammation and pyroptosis in response to brain ischemia via activating Sirt1 signaling

Tao Wang
Ya-Juan Pan
Jian-Meng Lv
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-9
Cerebrospinal fluid circulating tumor DNA profiling for risk stratification and matched treatment of central nervous system metastases

Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized therapies.

Mei-Mei Zheng
Qing Zhou
Yi-Long Wu
Research27 Feb 2025
Nature Medicine

Volume: 31, P: 1547-1556
Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma

Poorly differentiated hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis. Here the authors show that GDF1, a member of the TGF-β superfamily, is highly expressed in high-grade poorly differentiated HCC and is associated with tumor plasticity, and that GDF1-induced reexpression of cancer testis antigens could render tumors sensitive to immune checkpoint inhibition.

Wei Cheng
Hao-Long Li
Ming Liu
ResearchOpen Access08 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

Severe acne is a common skin disease characterized by chronic inflammation and potential scarring. Here, the authors have identified genetic variants at two loci associated with severe acne and provide insight into the genetic architecture and biological pathways underlying the disease.

Li He
Wen-Juan Wu
Ya-Ping Zhang
Research07 Jan 2014
Nature Communications

Volume: 5, P: 1-7
Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma

A silent single-nucleotide variant (SNV) affecting the transcription of a long noncoding RNA (lncRNA EGFR-AS1) within the EGFR coding region alters the EGFR isoform ratio and modulates oncogene addiction and response to EGFR tyrosine kinase inhibitors in squamous-cell cancers. Proof-of-concept validation in patients supports the notion that this SNV and levels of the lncRNA could be used to predict response to therapy in a clinical setting. These results, together with findings by Bal et al., uncover the functional role of noncoding RNAs in modulating the response to targeted therapies in cancer.

Daniel S W Tan
Fui Teen Chong
N Gopalakrishna Iyer
Research18 Sept 2017
Nature Medicine

Volume: 23, P: 1167-1175
Correction: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Ke-Wu Zeng
Jing-Kang Wang
Pengfei Tu
Amendments and CorrectionsOpen Access04 Apr 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-2
Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation

Mei-Mei Xiao
Yu-Qi Zhang
Ceng Luo
ResearchOpen Access17 Nov 2016
Scientific Reports

Volume: 6, P: 1-17
Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval

Mei-Mei Shi
Ka-Min Fan
Zhi-Qiang Liu
ResearchOpen Access29 May 2019
Molecular Psychiatry

Volume: 25, P: 977-992
Correction: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Ke-Wu Zeng
Jing-Kang Wang
Pengfei Tu
Amendments and CorrectionsOpen Access12 Mar 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-2
Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Ke-Wu Zeng
Jing-Kang Wang
Pengfei Tu
ResearchOpen Access19 Feb 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-13

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