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Research (9)

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Showing 1–9 of 9 results

Advanced filters: Author: Meiling Bao Clear advanced filters

An MRI–pathology foundation model for noninvasive diagnosis and grading of prostate cancer

Shao et al. developed an MRI–pathology-based foundation model to assess the pathology of prostate cancer for diagnosis and grading of tumors. The model is noninvasive and outperforms current pathological assessments.

Lizhi Shao
Chao Liang
Shancheng Ren
Research02 Sept 2025
Nature Cancer

P: 1-17
Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation

Here the authors show that the E3 ligase GID4 can be harnessed for targeted protein degradation and present the crystal structure of the GID4–PROTAC–BRD4 ternary complex to elucidate the underlying molecular mechanisms.

Yanran Li
Kaiwen Bao
Cheng Dong
Research28 Apr 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1825-1837
A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

Mingqing Tang
Guoxing Ma
Ruian Xu
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-19
The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells

Jie Liu
Zhenxing Ren
Weihong Kuang
ResearchOpen Access05 Mar 2022
Cell Death Discovery

Volume: 8, P: 1-11
Bisphenol A causes melatonin biosynthesis epigenetic reprogramming of melatonin biosynthesis genes in arabidopsis thaliana

Plants use epigenetic melatonin reprogramming to fight bisphenol A (BPA)-induced stress. This boosts antioxidant defenses, reducing BPA’s harmful effects. The gene AT1G26220 is key to this plant stress response mechanism.

Yu Zheng
Chun Bao
Yong Liang
ResearchOpen Access30 Jul 2025
Communications Biology

Volume: 8, P: 1-15
Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex

The organization of top-down inputs in primary visual cortex (V1) remains unclear. Here the authors characterized corticocortical and thalamocortical top-down inputs recruiting V1 neurons with cell-type and layer-specificities, and revealed distinct forms of top-down input processing.

Yanmei Liu
Jiahe Zhang
Guofen Ma
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-18
Acceptance and commitment therapy among caregivers of people with cancer: a systematic review and meta-analysis

Yunfan Gu
Mingyu Duan
Fang Yang
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Metabolic phenotypes and fatty acid profiles associated with histopathology of primary aldosteronism

Yuhong Yang
Yuqing Liu
Min Sun
Research13 Feb 2025
Hypertension Research

Volume: 48, P: 1363-1378
Circadian control of stress granules by oscillating EIF2α

Ruiqi Wang
Xin Jiang
Jin Xu
ResearchOpen Access04 Mar 2019
Cell Death & Disease

Volume: 10, P: 1-12