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Showing 1–9 of 9 results
Advanced filters: Author: Meixin Yan Clear advanced filters

  • Electron-deficient nitrogen-containing aromatic heterocycles can be converted into all-carbon aromatic frameworks via skeletal editing but reported methods are mainly limited to nucleophilic modification of ring-opening species. Here the authors report an electrophilic modification method which converts pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.

    • Meixin Yan
    • Yonglin Shi
    • Haiyan Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8

  • While one-to-one scaffold hopping strategies are thriving and evolving, one-to-multiple strategies remain challenging to design. Here, the authors report a scaffold hopping strategy for the skeletal editing of pyrimidines into a wide range of heteroarenes through the addition of nucleophiles, ring-opening, fragmentation, and ring-closing processes.

    • Shun Li
    • Yonglin Shi
    • Haiyan Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Despite delivering gene-specific silencing, the use of deoxyribozymes (DNAzymes) for cancer therapy is limited by toxicity due to off-target effects. Here, the authors develop a multi-component DNAzyme, targeting both miRNA21 and HSP70, to induce tumour-specific sensitisation to photothermal therapy in preclinical models of pancreatic cancer.

    • Jiaqi Yan
    • Xiaodong Ma
    • Hongbo Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Regioselective C–H functionalization of pyridines remains a persistent challenge due to their inherent electronically deficient properties. Here, the authors present a strategy for the selective pyridine C3-H thiolation, selenylation, and fluorination under mild conditions via classic N-2,4-dinitrophenyl Zincke imine intermediates.

    • Shun Li
    • Juan Tang
    • Haiyan Fu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Twisted 2D magnets provide a rich playground for potential spintronic device architectures. Here, the authors use tunneling magnetoresistance measurements to investigate the collective spin states of twisted double bilayer CrI3 in various configurations, providing evidence of non-volatile spin textures.

    • Bowen Yang
    • Tarun Patel
    • Adam W. Tsen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • The development of metal-nucleic acid nanocomposites for therapeutic is limited by poor stability and synthesis efficiency. Here, the authors develop a multi-fragmented aptamer DNAzyme metal-nucleic acid frameworks (MNFs) under milder conditions and demonstrate its preclinical efficacy in gastric cancer.

    • Jiaqi Yan
    • Rajendra Bhadane
    • Hongbo Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20