Nature Search

Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases

Tang, Yue, Xu and colleagues map the proteome of several thousand individuals over a 9-year period to identify potential biomarkers of ageing and of age-associated diseases.

Jun Tang
Liang Yue
Ju-Sheng Zheng
ResearchOpen Access13 Jan 2025
Nature Metabolism

Volume: 7, P: 166-181
Perovskite/silicon tandem solar cells with bilayer interface passivation

A power conversion efficiency of 33.89% is achieved in perovskite/silicon tandem solar cells by using a bilayer passivation strategy to enhance electron extraction and suppress recombination.

Jiang Liu
Yongcai He
Xixiang Xu
Research05 Sept 2024
Nature

Volume: 635, P: 596-603
Comparison of fecal and blood metabolome reveals inconsistent associations of the gut microbiota with cardiometabolic diseases

Here, analyzing paired fecal and blood metabolomics and metagenomics data in a large cohort, Deng et al. uncover disparate associations of the gut microbiota with cardiometabolic diseases when utilizing either fecal or blood metabolome data, suggesting that sampling criteria may be a relevant factor in metabolomics-based association studies.

Kui Deng
Jin-jian Xu
Yu-ming Chen
ResearchOpen Access02 Feb 2023
Nature Communications

Volume: 14, P: 1-12
Enhanced clinical assessment of hematologic malignancies through routine paired tumor and normal sequencing

Targeted sequencing panels such as MSK-IMPACT have been successfully used to profile solid tumours in clinical settings. Here, the authors develop and implement the MSK-IMPACT Heme sequencing panel and platform to profile haematologic malignancies using paired tumor and normal tissues.

Ryan N. Ptashkin
Mark D. Ewalt
Maria E. Arcila
ResearchOpen Access28 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

Integrating genetic information with circulating proteomics can help understand mechanisms of disease. Here, the authors conduct genome-wide association analyses of the serum proteome in 2,958 Han Chinese individuals, uncovering proteins which may contribute to ancestry differences in cardiometabolic disease susceptibility.

Fengzhe Xu
Evan Yi-Wen Yu
Ju-Sheng Zheng
ResearchOpen Access16 Feb 2023
Nature Communications

Volume: 14, P: 1-12
Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets

Fibroadenoma occurrence is linked to increased long-term risk of breast carcinoma, however, the lack of models has made understanding this mechanism unclear. Here, the authors use single cell RNA-seq to identify dysregulation of epithelial cells and develop organoid models to study treatment resistance.

Zhigang Chen
Yi Zhang
Jian Huang
ResearchOpen Access16 Jun 2023
Nature Communications

Volume: 14, P: 1-12
The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Chronic insomnia is associated with cardiometabolic diseases. Here, in two clinical cohorts (n = 7,931), authors show that gut microbiota-bile acid axis may be an intervention target to attenuate the impact of chronic insomnia on cardiometabolic health.

Zengliang Jiang
Lai-bao Zhuo
Ju-Sheng Zheng
ResearchOpen Access30 May 2022
Nature Communications

Volume: 13, P: 1-13
An Innovative Approach for Enhancing Bone Defect Healing Using PLGA Scaffolds Seeded with Extracorporeal-shock-wave-treated Bone Marrow Mesenchymal Stem Cells (BMSCs)

Youbin Chen
Jiankun Xu
Jun Hu
ResearchOpen Access08 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
Focal Adhesion Kinase Signaling Mediated the Enhancement of Osteogenesis of Human Mesenchymal Stem Cells Induced by Extracorporeal Shockwave

Jun Hu
Haojie Liao
Jiankun Xu
ResearchOpen Access11 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Viral infection/reactivation during long-term follow-up in multiple myeloma patients with anti-BCMA CAR therapy

Di Wang
Xia Mao
Jianfeng Zhou
CorrespondenceOpen Access18 Oct 2021
Blood Cancer Journal

Volume: 11, P: 1-4

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