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Resistive switching in metal oxides is related to the migration of donor defects. Here Baeumer et al. use in operandoX-ray spectromicroscopy to quantify the doping locally and show that small local variations in the donor concentration result in large variations in the device resistance.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactivate BRISC, promoting interferon receptor ubiquitylation and degradation to dampen immune responses.

Controlling light at scales smaller than its wavelength is attractive to manipulate light using small device footprints. Here, the authors propose a scheme to modify light on such small scales using a combination of metamaterial nanocavities coupled to nonlinear semiconductor heterostructures.

A method called MEDUSA was developed for identifying death regulatory genes in chemo-genetic profiling data, which enables characterization of a previously unappreciated mechanism of death induced by DNA damage in p53-deficient cells.

Antiskyrmions are topological spin textures with negative vorticity. Like skyrmions, they have considerable technological promise, but have only been stabilised in Heusler compounds. Here, Heigl et al. succeed in stabilising first and second order antiskyrmions in a new class of materials.

While machine learning platforms can improve the assessment of Hematoxylin & Eosin (H&E) stained-tumour tissue images, current models typically require manual cell-type annotations in training. Here, the authors develop VOLTA, a self-supervised machine learning framework to improve cell representation learning in H&E images based on the cells environment

Quantum spin Hall edge states are protected by time-reversal symmetry and are expected to disappear in a strong magnetic field. Here, the authors use microwave impedance microscopy and find, surprisingly, edge conduction in mercury telluride quantum wells that survives up to 9 T with little change.

Local probes of quantum Hall states are still in their infancy. Now scanning tunnelling measurements were used to extract the energy gap of candidate non-Abelian fractional states, which are found to be encouragingly large for applications.

Phenotypic profiling by high-throughput imaging can aid in the screening of perturbations in cell models, but most studies often overlook cell-to-cell variation of responses within samples/populations. Here, the authors present SPACe, an easy-to-deploy, open-source platform for analysis of single-cell image-based morphological profiles produced by Cell Painting.

AmpG is an MFS importer of bacterial cell wall fragments. Here, authors present a cryoEM structure and supporting mutagenesis to illuminate AmpG’s essential role in bacterial fitness and derepression of broad-spectrum β-lactam antibiotic resistance.

A compact ternary content-addressable memory cell, which is based on two ferroelectric field-effect transistors, can provide memory augmented neural networks with improved energy and latency performance compared with traditional approaches based on graphics processing units.

Rzemieniewski et al. demonstrated that Arabidopsis thaliana CEPs regulate immunity via three CEP receptors with distinct expression patterns and ligand specificities. CEPs and their receptors coordinate nitrogen availability with immune responses.

A bilayer Fermi–Hubbard model is realized in two coupled two-dimensional layers of fermionic ultracold atoms by tuning the interlayer coupling strength to create a crossover between magnetic orderings.

Targeted protein degradation of cell-surface glycoproteins suppresses cancer in mice.

Precise control of electrons in two-dimensional materials has been limited by fabrication techniques for local gates that introduce disorder. Now, a technique allows patterning of sub-100 nm features and fabrication of very clean interfaces.

Yu and colleagues report that migrasome formation depends on tetraspanin and cholesterol. Macrodomains formed by clustering of tetraspanin- and cholesterol-enriched membrane domains swell to generate migrasomes.

Dirac magnetoexcitons with non-trivial nanoscale electrodynamics are formed from the excitation of Landau levels in charge-neutral graphene. Here, the Dirac magnetoexciton dispersion is directly imaged up to 7 T via a magneto cryogenic near-field microscope.

Type 2 inflammation drives the formation of pathologic mucus in patients with asthma. Here, authors reveal a role for intelectin-1 in IL-13-induced mucus properties, and that an ITLN1 eQTL is associated with protection from the formation of mucus plugs in T2-high asthma.

The agrochemical mandipropamid (Mandi), which induces dimerization of a variant of the abscisic acid receptor, has been developed as a new chemical inducer of proximity for cellular and organismal applications.

We propose high-performance, tunable twisted bilayers for beam steering. An analytical model reveals their operation principles, enabling the design of simplified, efficient device candidates.

The spatiotemporal pattern of synaptic inputs is critical for synaptic integration and plasticity in neurons but whether these inputs are structured or random is not clear. Here the authors use in vivocalcium imaging to monitor the presynaptic activity of cerebellar parallel fibre axons and find clustered patterns of axonal activity during sensory processing.

Li, Lu et al. demonstrate that O-GlcNAcylation enhances angiogenic transdifferentiation from fibroblasts to endothelial cells through a HIRA-dependent H3.3 deposition mechanism and facilitates vascular regeneration.

Cell type classification is commonly used to interpret the connectivity and functional output of neuronal networks. Here, Sümbül et al. combine structural and genetic approaches to provide a higher resolution classification of neuronal subtypes.

In mouse, an axonal connectivity map showing the wiring patterns across the entire brain has been created using an EGFP-expressing adeno-associated virus tracing technique, providing the first such whole-brain map for a vertebrate species.

How past climate change has affected biodiversity over large spatial scales remains underexplored. Here, the authors find marked homogenization in flowering plant phylogenetic diversity across Central and Northern Europe linked to rapid climate change and large distances to glacial refugia.

Structural analysis of Mango-III in complex with fluorophores reveals a globular architecture and a planar conformation of fluorophores. Structure-guided mutation and functional reselection identified two mutants with improved fluorescence intensity.

Three-dimensional cell-laden photosensitive polymer hydrogels can be bioprinted in tissues of live animals, by bio-orthogonal two-photon cycloaddition and crosslinking of the polymers.

This paper highlights the far-red chemigenetic H₂O₂ reporter oROS-HT₆₃₅, which enables detailed insights into intricate intracellular and intercellular H₂O₂ dynamics, along with their environmental interactants, through spatially resolved, multiplexed real-time H₂O₂ imaging.

Polymer brushes are often used to functionalise surfaces. Here, the authors report on the creation of high-density, regenerating hyaluronan brushes using hyaluronan synthase enzymes which can be patterned by photo-deactivation and demonstrate biocompatibility and resistance to biofilm formation.

Raman and fluorescence spectra, consistent with several species of aromatic organic molecules, are reported in the Crater Floor sequences of Jezero crater, Mars, suggesting multiple mechanisms of organic synthesis, transport, or preservation.

Here, the authors demonstrate acousto-optic modulation of silicon nitride microring resonators using high-overtone bulk acoustic wave resonances, allowing modulation in the GHz range via acoustic waves. As an application, an optical isolator is demonstrated with 17 dB non-reciprocity.

The epicardium supports heart regeneration, though precisely how is unclear. Here the authors define an activated epicardial progenitor population as the source of essential cell types and paracrine factors for successful heart regeneration in zebrafish.

Tröger et al. identify a positioning and tethering process ensuring proper mitochondrial distribution during dendritic arbor formation of neurons and reveal the first molecular players - rhotekin2 and syndapin I - and underlying mechanisms.

Degenerative diseases such as Alzheimer's or Parkinson's are associated with the misfolding of many diverse proteins, yet the amyloid fibrils formed by all these proteins are similar. David Eisenberg and colleagues have now identified 30 short fibril-forming peptides implicated in a range of amyloid diseases and have solved 13 of their atomic structures, revealing variations in one common feature — the 'steric zipper'.

Bacteriophages of the Siphoviridae family have a long, flexible, non-contractile tail that has been difficult to characterize structurally. Here, the authors present the atomic structure of the tail tube of one of these phages, showing a hollow flexible tube formed by hexameric rings stacked by flexible linkers.

We present a protocol for preparing microcrystal samples for cryo-EM diffraction imaging, including room temperature solid-state small molecules and soluble and membrane protein crystals.

Novak, Lin et al. use AI computational drug prediction and CRISPR-enabled in vivo disease modeling to identify therapeutic strategies for the treatment of Rett syndrome. Findings reveal the therapeutic efficacy of vorinostat in a mouse model of Rett syndrome.

In Drosophila, the physical structure of the eye has a key role in the directional tuning of motion-sensitive neurons, showing how navigational behaviour is tightly associated with anatomy.

Substantial open-circuit voltage loss and inherent non-radiative recombination hinder efficiency improvements in wide-bandgap perovskite solar cells. Here the authors augment two-dimensional perovskite phases on the surface to promote (100) facet growth on three-dimensional perovskite facets, improving the open-circuit voltage and efficiency of the resulting wide-bandgap perovskite solar cells.

How stable sensory and motor variables are represented in association brain areas such as retrosplenial cortex (RSC) during the performance of a cognitive task is not fully understood. Here authors show that mouse RSC can reliably store sensory information about the environmental context and trial outcome while exhibiting flexible coding of motor choice.

Charge transfer in DNA is of fundamental interest in chemistry and biochemistry and has possible applications in nano-electronics. Now it has been shown, through a combined experimental and theoretical study, that the migration of positive charges through low-lying orbitals of nucleobases (deep-hole transfer) leads to charge transfer that is faster than previously considered transport regimes.

The parasite Toxoplasma gondii secretes a virulence factor, the kinase ROP17 that modulates Rho–ROCK signalling in the infected host cell, enhancing monocyte motility on the surface of endothelial cells and inhibiting transmigration across endothelial barriers.