Search

Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling throughout invasion.

By combining a CMOS-based integrated circuit with flexible and collapsible radiating structures, a scalable phased array architecture can be fabricated that has an areal mass density of only 0.1 g cm⁻².

The behaviour of a superconductor can be altered by changing its symmetry properties. Coherently coupling two Josephson junctions breaks time-reversal and inversion symmetries, giving rise to a device with a controllable superconducting diode effect.

Growth of high-quality III–V semiconductors for electronics and optoelectronics usually requires an atomic-lattice matched substrate. Here, the authors use templated liquid-phase crystal growth to create single-crystalline III–V material up to ten micrometres across on an amorphous substrate.

Resistive switching in metal oxides is related to the migration of donor defects. Here Baeumer et al. use in operandoX-ray spectromicroscopy to quantify the doping locally and show that small local variations in the donor concentration result in large variations in the device resistance.

Nerve injury activates microglia to remove spinal synapses, disrupting spinal sensory processing and contributing to chronic pain. Blocking complement protein C1q preserves synapses, highlighting a potential therapeutic target for neuropathic pain.

Evidence for a past large explosive eruption within the Santorini caldera suggests that early stages of silicic caldera cycles can be more hazardous than previously assumed, according to analyses of intra-caldera deposits from the Kameni Volcano.

Controlling light at scales smaller than its wavelength is attractive to manipulate light using small device footprints. Here, the authors propose a scheme to modify light on such small scales using a combination of metamaterial nanocavities coupled to nonlinear semiconductor heterostructures.

The actin-based motor Myosin1d is needed to establish left–right asymmetry in Drosophila. Here the authors show that myosin 1d has a role in lumen formation, vacuole trafficking and left-right asymmetry establishment during zebrafish development.

Antiskyrmions are topological spin textures with negative vorticity. Like skyrmions, they have considerable technological promise, but have only been stabilised in Heusler compounds. Here, Heigl et al. succeed in stabilising first and second order antiskyrmions in a new class of materials.

While the impact of F-actin architecture on stress transmission is well studied, the role of architecture on stress generation remains unclear. Here authors use in vitro model and show that distinct organizations constrain myosin motion.

Quantum spin Hall edge states are protected by time-reversal symmetry and are expected to disappear in a strong magnetic field. Here, the authors use microwave impedance microscopy and find, surprisingly, edge conduction in mercury telluride quantum wells that survives up to 9 T with little change.

Genetic disposition can impact response to virus infection. Here, the authors used a reinfection approach with antigenically distinct SARS-CoV-2 variants Omicron and Beta and show that differences in the immune response correlate with disease outcome in mouse models with different genetic background upon reinfection.

Authors show that Antarctic glaciers deliver high particle loads to the ocean, rich in iron that is potential food for marine algae. Microscopy techniques reveal this iron interacts with carbon. Ocean tracers show this glacial iron reaches far offshore.

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially resolved single-cell atlas of human fetal cortical development.

Tetrahydrocannabinol (THC) analogs target the cannabinoid receptor CB1 for therapeutic and psychoactive effects. Here, the authors determine spatiotemporal ligand interactions critical for potency, efficacy, off-rates and drug design.

The authors show an original approach to achieve strong light-matter interaction harnessing the coupling between plasmonic resonators and the Landau resonances of an underlying quantum well, demonstrating remarkably high coupling strengths.

Here the authors report single-cell and spatial transcriptomics of young and aged male fibrotic mouse lungs. Age-related alterations in capillary sub-populations are associated with a proangiogenic phenotype linked to regeneration of the alveolar niche.

Aerosol deposition onto the surface of the ocean has been underestimated, suggesting that aerosol lifetimes over the ocean are longer than previously appreciated, according to a global compilation of cosmogenic beryllium isotope data.

A compact ternary content-addressable memory cell, which is based on two ferroelectric field-effect transistors, can provide memory augmented neural networks with improved energy and latency performance compared with traditional approaches based on graphics processing units.

Stress transitions from horizontally forced compression to vertically forced extension during subduction initiation, according to seismic images of the Puysegur plate boundary, New Zealand.

Yu and colleagues report that migrasome formation depends on tetraspanin and cholesterol. Macrodomains formed by clustering of tetraspanin- and cholesterol-enriched membrane domains swell to generate migrasomes.

150 years ago, guanidine was found to affect muscle function via unknown mechanisms. Here, Kavita et al. provide evidence that guanine-sensing RNAs are present in many eukaryotic transcripts relevant to Ca2+ signaling and neuromuscular function.

The Nikon A1R HD25 confocal system with NIS-Elements AI software enables rapid, deep, quantitative imaging of living organs-on-chips.

The agrochemical mandipropamid (Mandi), which induces dimerization of a variant of the abscisic acid receptor, has been developed as a new chemical inducer of proximity for cellular and organismal applications.

The spatiotemporal pattern of synaptic inputs is critical for synaptic integration and plasticity in neurons but whether these inputs are structured or random is not clear. Here the authors use in vivocalcium imaging to monitor the presynaptic activity of cerebellar parallel fibre axons and find clustered patterns of axonal activity during sensory processing.

Dynamic interface printing is a new form of 3D printing that leverages an acoustically modulated, constrained air–liquid boundary to rapidly generate centimetre-scale 3D structures within tens of seconds.

Cell type classification is commonly used to interpret the connectivity and functional output of neuronal networks. Here, Sümbül et al. combine structural and genetic approaches to provide a higher resolution classification of neuronal subtypes.

In mouse, an axonal connectivity map showing the wiring patterns across the entire brain has been created using an EGFP-expressing adeno-associated virus tracing technique, providing the first such whole-brain map for a vertebrate species.

Three-dimensional cell-laden photosensitive polymer hydrogels can be bioprinted in tissues of live animals, by bio-orthogonal two-photon cycloaddition and crosslinking of the polymers.

A method called MEDUSA was developed for identifying death regulatory genes in chemo-genetic profiling data, which enables characterization of a previously unappreciated mechanism of death induced by DNA damage in p53-deficient cells.

Degenerative diseases such as Alzheimer's or Parkinson's are associated with the misfolding of many diverse proteins, yet the amyloid fibrils formed by all these proteins are similar. David Eisenberg and colleagues have now identified 30 short fibril-forming peptides implicated in a range of amyloid diseases and have solved 13 of their atomic structures, revealing variations in one common feature — the 'steric zipper'.

Structural analysis of Mango-III in complex with fluorophores reveals a globular architecture and a planar conformation of fluorophores. Structure-guided mutation and functional reselection identified two mutants with improved fluorescence intensity.

A bilayer Fermi–Hubbard model is realized in two coupled two-dimensional layers of fermionic ultracold atoms by tuning the interlayer coupling strength to create a crossover between magnetic orderings.

Here, the authors demonstrate acousto-optic modulation of silicon nitride microring resonators using high-overtone bulk acoustic wave resonances, allowing modulation in the GHz range via acoustic waves. As an application, an optical isolator is demonstrated with 17 dB non-reciprocity.

Polymer brushes are often used to functionalise surfaces. Here, the authors report on the creation of high-density, regenerating hyaluronan brushes using hyaluronan synthase enzymes which can be patterned by photo-deactivation and demonstrate biocompatibility and resistance to biofilm formation.

Confining atoms to lattices can modify their interaction and collision. Here the authors show suppression of dipolar relaxation in the form of reduced decay rate of dysprosium atoms in quasi-2D regime.

Roy-Chowdhury et al. report structures of the human leak channel K_2P13.1 that identify a hydrophilic pore restriction and a polyunsaturated-fatty-acid-binding site corresponding to a small-molecule agonist site in the K_2P family.

The authors report the measurement of the Little-Parks effect in the unconventional superconductor candidate 4Hb-TaS₂. They find a π-shift in the transition-temperature oscillations and an ehancement of T_c as a function of the out-of-plane field when a constant in-plane field is applied, consistent with a multi-component order parameter.

Using visible-light-induced crosslinking, a local stiffening approach is developed for ex vivo mouse and human lung tissue as an early lung injury model, directing epithelial cell mechanosensing, differentiation and nascent protein deposition.

Targeted protein degradation of cell-surface glycoproteins suppresses cancer in mice.

Precise control of electrons in two-dimensional materials has been limited by fabrication techniques for local gates that introduce disorder. Now, a technique allows patterning of sub-100 nm features and fabrication of very clean interfaces.

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

In silicon, quantum information can be stored in donors or quantum dots, each with its advantages and limitations—particularly in terms of fabrication. Here the authors coherently couple a phosphorous donor’s electron spin to a quantum dot, encoding information in the hybrid two-electron system’s state.

Charge transfer in DNA is of fundamental interest in chemistry and biochemistry and has possible applications in nano-electronics. Now it has been shown, through a combined experimental and theoretical study, that the migration of positive charges through low-lying orbitals of nucleobases (deep-hole transfer) leads to charge transfer that is faster than previously considered transport regimes.