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Showing 1–11 of 11 results
Advanced filters: Author: Michael C. Turchin Clear advanced filters

  • The Seshat database has made it possible to reveal large-scale patterns in human cultural evolution. Here, Shin et al. investigate transitions in social complexity and find alternating thresholds of polity size and information processing required for further sociopolitical development.

    • Jaeweon Shin
    • Michael Holton Price
    • Timothy A. Kohler
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

    • Krista Freimann
    • Anneke Brümmer
    • Kaur Alasoo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • This very large genome-wide association study identifies hundreds of new genetic variants influencing adult height in at least 180 loci enriched for genes involved in skeletal growth defects. The results show that the likely causal gene is often located near the most strongly associated variant, that many loci have multiple independently associated variants and that associated variants are enriched for likely functional effects on genes.

    • Hana Lango Allen
    • Karol Estrada
    • Joel N. Hirschhorn
    Research
    Nature
    Volume: 467, P: 832-838

  • A new study generated and optimized a polygenic score for chronic kidney disease with reproducible performance across 15 cohorts of different ancestries, and identified potentially clinically relevant thresholds with predicted effects comparable to having a family history of the disease.

    • Atlas Khan
    • Michael C. Turchin
    • Krzysztof Kiryluk
    Research
    Nature Medicine
    Volume: 28, P: 1412-1420

  • Jonathan Pritchard, Guy Sella and colleagues report an analysis using population genetic models to show that recent human demography is likely to have had little impact on the average burden of deleterious mutations. They examine two large exome sequence datasets and find that individuals of west African and European ancestry carry similar burdens of damaging mutations.

    • Yuval B Simons
    • Michael C Turchin
    • Guy Sella
    Research
    Nature Genetics
    Volume: 46, P: 220-224

  • Joseph Gleeson and colleagues report whole-exome sequencing of a cohort of over 1,000 individuals from the Greater Middle East, characterizing common and rare variants. They find evidence of subregional diversity and historical migrations and use the GME Variome to identify disease-causing mutations.

    • Eric M Scott
    • Anason Halees
    • Joseph G Gleeson
    Research
    Nature Genetics
    Volume: 48, P: 1071-1076