Nature Search

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D₂ Blockade

Paul B Fitzgerald
Shitij Kapur
Robert B Zipursky
Research01 Jan 2000
Neuropsychopharmacology

Volume: 22, P: 19-26
Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy

The authors show that the m⁶A reader protein YTHDF2 negatively regulates Th9 cell differentiation and function. Ablation of YTHDF2 promotes antigen-specific Th9 cell and CAR-Th9 cell antitumor activity in solid tumors.

Sai Xiao
Songqi Duan
Jianhua Yu
Research18 Aug 2025
Nature Immunology

Volume: 26, P: 1501-1515
YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8⁺ T cells

Caligiuri and colleagues show that the m⁶A reader YTHDF2 modulates the inflammatory activation and antitumor function of tumor-associated macrophages in part by modulating the stability of Stat1 mRNA.

Shoubao Ma
Baofa Sun
Jianhua Yu
Research19 Jan 2023
Nature Immunology

Volume: 24, P: 255-266
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Tsvee Lapidot
Christian Sirard
John E. Dick
Research17 Feb 1994
Nature

Volume: 367, P: 645-648
CD3-negative natural killer cells express ε TCR as part of a novel molecular complex

Paul Anderson
Michael Caligiuri
Stuart F. Schlossman
Research14 Sept 1989
Nature

Volume: 341, P: 159-162
A role for IL-15 in rheumatoid arthritis?

Manisha H. Shah
Kevin V. Hackshaw
Michael A. Caligiuri
Correspondence01 Jun 1998
Nature Medicine

Volume: 4, P: 643
miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape

Acquired miR-142 deficit in leukemic stem cells has been associated with chronic myeloid leukemia blast crisis. Here the authors show that acquired miR-142 deficit in T cells further enables leukemic stem cells to escape immune surveillance and supports disease growth.

Fang Chen
Dandan Zhao
Bin Zhang
ResearchOpen Access01 Feb 2025
Nature Communications

Volume: 16, P: 1-21
NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity

It has been previously reported that the natural cytotoxic receptor NKp46 plays an important role in regulating natural killer (NK) cell biology. Here the authors show that NKp46 is required for the proliferation and cytotoxicity of type 1 innate lymphoid cells (ILCs) by activating the NF-κB signaling pathway and regulating IL-2Rα expression.

Rui Ma
Zhenlong Li
Jianhua Yu
ResearchOpen Access24 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Correction: Amendments: Publisher Correction: An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma

Bo Xu
Rui Ma
Jianhua Yu
Amendments and Corrections03 Jan 2019
Nature Biotechnology

Volume: 37, P: 102
Publisher Correction: ILC1s control leukemia stem cell fate and limit development of AML

Zhenlong Li
Rui Ma
Jianhua Yu
Amendments and Corrections15 Jun 2022
Nature Immunology

Volume: 23, P: 1286
Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19

Severe COVID-19 requires immediate and targeted intervention that is efficient against SARS-CoV-2 and its variants. Authors show here the therapeutic potential of engineered natural killer cells that simultaneously express a chimeric antigen receptor targeting the spike protein of SARS-CoV-2, and IL-15, a cytokine that enhances the function and survival of their own.

Ting Lu
Rui Ma
Jianhua Yu
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-11
What does it take to make a natural killer?

Francesco Colucci
Michael A. Caligiuri
James P. Di Santo
Reviews01 May 2003
Nature Reviews Immunology

Volume: 3, P: 413-425
Host response during unresolved urinary tract infection alters female mammary tissue homeostasis through collagen deposition and TIMP1

Urinary tract infections (UTIs) can elicit systemic host-responses. Here the authors report that, in a mouse model, unresolved UTI is associated with alterations of the mammary tissue, including collagen deposition and hyperplasia.

Samantha Henry
Steven Macauley Lewis
Camila Oresco dos Santos
ResearchOpen Access16 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 526
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

Jennifer C Felger
Michael T Treadway
Reviews02 Aug 2016
Neuropsychopharmacology

Volume: 42, P: 216-241
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors

Oncolytic virotherapy has been tested in cancer patients, but its efficacy is uncertain. Alvarez-Breckenridge et al. now report that in mouse models of glioblastoma, an antiviral response mediated by natural killer (NK) cells may impair the anticancer efficacy of oncolytic virotherapy. Their findings suggest that limiting the cytolytic activity of NK cells might enhance replication of oncolytic viruses and increase tumor cell killing.

Christopher A Alvarez-Breckenridge
Jianhua Yu
E Antonio Chiocca
Research25 Nov 2012
Nature Medicine

Volume: 18, P: 1827-1834
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

Li Yu
Chunhui Liu
Christoph Plass
Research20 Feb 2005
Nature Genetics

Volume: 37, P: 265-274
Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity

Yu and colleagues develop a OV-Cmab-CCL5 oncolytic virus that targets EGFR⁺ glioblastoma cells and releases CCL5 into the tumor microenvironment, which promotes anti-tumor immune responses and prolonged survival in preclinical GBM models.

Lei Tian
Bo Xu
Jianhua Yu
Research10 Nov 2022
Nature Cancer

Volume: 3, P: 1318-1335
PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance

Oncolytic viruses are a promising therapeutic approach for cancer treatment. The authors demonstrate the efficacy of an engineered HSV-1 expressing PTENα as an oncolytic and immune stimulating therapy against brain cancer metastases.

Luke Russell
Jessica Swanner
Balveen Kaur
ResearchOpen Access27 Nov 2018
Nature Communications

Volume: 9, P: 1-16
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 282-291
Gene expression profiling reveals fundamental biological differences in AML with trisomy 8 and normal cytogenetics

Kimmo I. Virtaneva
Fred A. Wright
Ralf Krahe
Research Highlights01 Apr 2001
Nature Genetics

Volume: 27, P: 65
Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis

The molecular mechanisms underlying the transformation of Chronic Myeloid Leukaemia (CML) from chronic phase (CP) to blast crisis (BC) are not completely elucidated. Here, the authors show that acquired miR-142 deficiency drives CML BC by regulating mitochondrial metabolism and is a potential therapeutic target to prevent BC in CML murine models.

Bin Zhang
Dandan Zhao
Guido Marcucci
ResearchOpen Access01 Sept 2023
Nature Communications

Volume: 14, P: 1-21
Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation

Isabela Pedroza-Pacheco
Divya Shah
Aurore Saudemont
ResearchOpen Access26 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection

The serine protease factor Xa (FXa) is upregulated in COVID-19 patients and functions in the coagulation pathway. Here, Dong et al characterise the basis of its antiviral activity in the context of SARS-CoV-2 pandemic variants.

Wenjuan Dong
Jing Wang
Jianhua Yu
ResearchOpen Access06 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

Obesity is associated with inflammation in adipose tissue, characterized by a shift in local T cell subsets. Here the authors show that loss of MHCII expression on adipocytes increases levels of immunosuppressive regulatory T cells in adipose tissue, which enhances insulin sensitivity.

Tuo Deng
Joey Liu
Willa A. Hsueh
ResearchOpen Access12 Jul 2017
Nature Communications

Volume: 8, P: 1-11
ILC1s control leukemia stem cell fate and limit development of AML

How ILC1s respond to cancer cells is somewhat controversial. Here, the authors show that IFNγ released by ILC1s can control acute myeloid leukemia by promoting leukemia stem cell apoptosis and favoring their differentiation into non-leukemic cells.

Zhenlong Li
Rui Ma
Jianhua Yu
Research29 Apr 2022
Nature Immunology

Volume: 23, P: 718-730
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development

Ikaros, Helios and Aiolos are transcription factors involved in lymphocyte development. Here the authors dissect the regulatory role of these Ikaros family members to understand their contribution to NK cell development and functions.

Wilford Goh
Harrison Sudholz
Nicholas D. Huntington
Research05 Jan 2024
Nature Immunology

Volume: 25, P: 240-255
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing anti-CD47 antibodies improve glioblastoma survival in mouse models.

Bo Xu
Lei Tian
Jianhua Yu
ResearchOpen Access08 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues

Steven D. Scoville
Karen A. Keller
Aharon G. Freud
ResearchOpen Access30 Jul 2015
Scientific Reports

Volume: 5, P: 1-6
An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma

An engineered oncolytic herpesvirus shows enhanced intratumoral spread, resistance to NK cell clearance and improved efficacy against brain cancer in mice.

Bo Xu
Rui Ma
Jianhua Yu
Research26 Nov 2018
Nature Biotechnology

Volume: 37, P: 45-54
Cancer T cell therapy expands

Coaxing T cells into attacking tumors is an intelligent approach to cancer therapy that has met with limited success. A new study applies some very persuasive techniques (pages 279–286).

Brian Becknell
Michael A. Caligiuri
News & Views01 Mar 2003
Nature Medicine

Volume: 9, P: 257-258
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Timothy J. Ley
Elaine R. Mardis
Richard K. Wilson
ResearchOpen Access06 Nov 2008
Nature

Volume: 456, P: 66-72
BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2

Danilo Perrotti
Vincenzo Cesi
Bruno Calabretta
Research20 Dec 2001
Nature Genetics

Volume: 30, P: 48-58
Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Anna M. Paczulla
Kathrin Rothfelder
Claudia Lengerke
Amendments and Corrections01 Aug 2019
Nature

Volume: 572, P: E19
Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene

Christoph Plass
Feng Yu
Michael A Caligiuri
Research25 May 1999
Oncogene

Volume: 18, P: 3159-3165
Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

Joseph F. Costello
Michael C. Frühwald
Christoph Plass
Research01 Feb 2000
Nature Genetics

Volume: 24, P: 132-138
The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells

Yu and colleagues show that the transcription factor XBP1s positively regulates the cytolytic activity of human NK cells and is required for the IL-15-mediated survival of NK cells.

Yufeng Wang
Yibo Zhang
Jianhua Yu
Research10 Dec 2018
Nature Immunology

Volume: 20, P: 10-17
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Leukaemic stem cells in acute myeloid leukaemia are defined by a lack of expression of NKG2D ligands, which mediates their ability to evade surveillance by NK cells.

Anna M. Paczulla
Kathrin Rothfelder
Claudia Lengerke
Research17 Jul 2019
Nature

Volume: 572, P: 254-259
Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Michael P Caligiuri
Casey Buitenhuys
Reviews10 Aug 2005
Neuropsychopharmacology

Volume: 30, P: 2125-2134
Predictors of oxylipins in a healthy pediatric population

Teresa Buckner
Lauren A. Vanderlinden
Jill M. Norris
Research29 Jul 2020
Pediatric Research

Volume: 89, P: 1530-1540
Modeling tumor immunity of mouse glioblastoma by exhausted CD8⁺ T cells

Hiroshi Nakashima
Quazim A. Alayo
E. Antonio Chiocca
ResearchOpen Access09 Jan 2018
Scientific Reports

Volume: 8, P: 1-10
CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

Jianfeng Han
Jianhong Chu
Jianhua Yu
ResearchOpen Access09 Jul 2015
Scientific Reports

Volume: 5, P: 1-13
GAS6 expression identifies high-risk adult AML patients: potential implications for therapy

S P Whitman
J Kohlschmidt
C D Bloomfield
Research11 Dec 2013
Leukemia

Volume: 28, P: 1252-1258
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

Paul M Ayton
Michael L Cleary
Reviews08 Oct 2001
Oncogene

Volume: 20, P: 5695-5707
AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M

Matteo Tardelli
Francesca V. Bruschi
Michael Trauner
ResearchOpen Access07 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Nitric oxide mediated inhibition of antigen presentation from DCs to CD4⁺ T cells in cancer and measurement of STAT1 nitration

Joseph Markowitz
Jiang Wang
William E. Carson
ResearchOpen Access13 Nov 2017
Scientific Reports

Volume: 7, P: 1-13
Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia

I-K Park
B Mundy-Bosse
M A Caligiuri
Research19 Jun 2015
Leukemia

Volume: 29, P: 2382-2389
Toward personalized therapy in AML: in vivo benefit of targeting aberrant epigenetics in MLL-PTD-associated AML

K M Bernot
R F Siebenaler
M A Caligiuri
Correspondence10 May 2013
Leukemia

Volume: 27, P: 2379-2382
E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia

I-K Park
W Blum
M A Caligiuri
Correspondence24 Oct 2016
Leukemia

Volume: 31, P: 502-505
The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia

S P Whitman
M A Caligiuri
C D Bloomfield
Correspondence07 Feb 2012
Leukemia

Volume: 26, P: 1713-1717

Search

Filter By:

Search

Quick links